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Title: | Is Intravenous and Oral Topotecan in Small-Cell Lung Cancer Truly Equal? A Case Report | Authors: | Deraedt, Davien Verfaillie, Saartje Wynants, Jokke CUPPENS, Kristof |
Issue Date: | 2024 | Publisher: | KARGER | Source: | Case reports in oncology, 17 (1) , p. 1140 -1145 | Abstract: | Introduction: Treatment with topotecan is standard-of-care therapy for relapsed small-cell lung cancer (SCLC). Both oral and intravenous administrations of topotecan have been extensively researched and are found to be equally effective with less adverse events in the oral group. Case Presentation: We report a case of a patient with SCLC, who had previously received oral topotecan, with radiological stable disease with no changes in tumor or metastasis diameter size after two administrations. Subsequently, this patient received intravenous topotecan instead of oral due to supply difficulties. After one administration of intravenous topotecan, we saw significant disease regression. Conclusion: This is to our knowledge the first reported case of better response of intravenous topotecan than oral topotecan. Multiple extrinsic (e.g., food, medication) factors were investigated but could not deliver an explanation. | Notes: | Deraedt, D (corresponding author), Sint Trudo Hosp, Dept Pulmonol, St Truiden, Belgium. davien.deraedt@uzleuven.be |
Keywords: | Topotecan;Oral administration;Intravenous administration;Small-cell lung cancer;Case report | Document URI: | http://hdl.handle.net/1942/44978 | ISSN: | 1662-6575 | e-ISSN: | 1662-6575 | DOI: | 10.1159/000540861 | ISI #: | 001376917900001 | Rights: | 2024 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Is Intravenous and Oral Topotecan in Small-Cell Lung Cancer Truly Equal_ A Case Report.pdf | Published version | 578.23 kB | Adobe PDF | View/Open |
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