Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/45277
Title: Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6–12 Years
Authors: Campos-Sánchez, Irene
Navarrete-Muñoz, Eva María
MARTENS, Dries 
Riaño-Galán, Isolina
Lertxundi, Aitana
Llop, Sabrina
Guxens, Mónica
Rodríguez-Dehli, Cristina
Lertxundi, Nerea
Soler-Blasco, Raquel
Vrijheid, Martine
NAWROT, Tim 
Wright, John
Yang, Tiffany C.
McEachan, Rosie
Gützkow, Kristine Bjerve
Chatzi, Vaia Lida
Vafeiadi, Marina
Kampouri, Mariza
Grazuleviciene, Regina
Andrusaityte, Sandra
Lepeule, Johanna
Valera-Gran, Desirée
Issue Date: 2025
Publisher: 
Source: Journal of attention disorders,
Status: Early view
Abstract: Objective:To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years. Method:Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners’ Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations. Results:Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = .022). Conclusion:While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.
Keywords: telomere length;attention deficit-hyperactivity disorder;neurodevelopment;children
Document URI: http://hdl.handle.net/1942/45277
ISSN: 1087-0547
e-ISSN: 1557-1246
DOI: 10.1177/10870547251314923
ISI #: 001408228000001
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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