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Title: | Clinical management and therapeutic optimization of patients with heart failure with reduced ejection fraction and low blood pressure. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC | Authors: | Skouri, Hadi Girerd, Nicolas Monzo, Luca Petrie, Mark C. Boehm, Michael Adamo, Marianna MULLENS, Wilfried Savarese, Gianluigi Yilmaz, Mehmet Birhan Amir, Offer Bayes-Genis, Antoni Bozkurt, Biykem Butler, Javed Chioncel, Ovidiu Mebazaa, Alexandre Merino, Jose L. Moura, Brenda Ponikowski, Piotr Seferovic, Petar Rosano, Giuseppe M. C. Metra, Marco |
Issue Date: | 2025 | Publisher: | WILEY | Source: | European journal of heart failure, | Status: | Early view | Abstract: | Despite major advancements in heart failure (HF) management and guideline recommendations over the past two decades, real-world evidence highlights suboptimal implementation of guideline-directed medical therapy (GDMT) for HF with reduced ejection fraction (HFrEF). Low blood pressure (BP) is common in HFrEF patients and represents a major perceived barrier to implementing life-saving treatments in clinical practice, as physicians are often concerned about symptomatic hypotension and its consequences. Although low BP can be seen in those hospitalized with signs of shock, the most common scenario involves non-severe, asymptomatic hypotension in patients receiving foundational therapy for HFrEF, where premature down-titration or discontinuation of GDMT should be avoided. This clinical consensus statement provides a comprehensive overview of low BP in HFrEF, including its definition, risk factors, and effects of HF therapies on BP. We propose management pathways to optimize HFrEF treatment in the context of low BP, ultimately aiming to improve patient outcomes. | Notes: | Skouri, H (corresponding author), Balamand Univ, Div Cardiol, Fac Med, Beirut, Lebanon. skourihadi73@gmail.com |
Keywords: | Blood pressure;Hypotension;Guideline-directed medical therapy;Treatment implementation;Heart failure with reduced ejection fraction | Document URI: | http://hdl.handle.net/1942/45654 | ISSN: | 1388-9842 | e-ISSN: | 1879-0844 | DOI: | 10.1002/ejhf.3618 | ISI #: | 001433452800001 | Rights: | 2025 European Society of Cardiology | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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European J of Heart Fail - 2025 - Skouri - Clinical management and therapeutic optimization of patients with heart failure.pdf Restricted Access | Early view | 6.87 MB | Adobe PDF | View/Open Request a copy |
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