Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/45654
Title: Clinical management and therapeutic optimization of patients with heart failure with reduced ejection fraction and low blood pressure. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC
Authors: Skouri, Hadi
Girerd, Nicolas
Monzo, Luca
Petrie, Mark C.
Boehm, Michael
Adamo, Marianna
MULLENS, Wilfried 
Savarese, Gianluigi
Yilmaz, Mehmet Birhan
Amir, Offer
Bayes-Genis, Antoni
Bozkurt, Biykem
Butler, Javed
Chioncel, Ovidiu
Mebazaa, Alexandre
Merino, Jose L.
Moura, Brenda
Ponikowski, Piotr
Seferovic, Petar
Rosano, Giuseppe M. C.
Metra, Marco
Issue Date: 2025
Publisher: WILEY
Source: European journal of heart failure,
Status: Early view
Abstract: Despite major advancements in heart failure (HF) management and guideline recommendations over the past two decades, real-world evidence highlights suboptimal implementation of guideline-directed medical therapy (GDMT) for HF with reduced ejection fraction (HFrEF). Low blood pressure (BP) is common in HFrEF patients and represents a major perceived barrier to implementing life-saving treatments in clinical practice, as physicians are often concerned about symptomatic hypotension and its consequences. Although low BP can be seen in those hospitalized with signs of shock, the most common scenario involves non-severe, asymptomatic hypotension in patients receiving foundational therapy for HFrEF, where premature down-titration or discontinuation of GDMT should be avoided. This clinical consensus statement provides a comprehensive overview of low BP in HFrEF, including its definition, risk factors, and effects of HF therapies on BP. We propose management pathways to optimize HFrEF treatment in the context of low BP, ultimately aiming to improve patient outcomes.
Notes: Skouri, H (corresponding author), Balamand Univ, Div Cardiol, Fac Med, Beirut, Lebanon.
skourihadi73@gmail.com
Keywords: Blood pressure;Hypotension;Guideline-directed medical therapy;Treatment implementation;Heart failure with reduced ejection fraction
Document URI: http://hdl.handle.net/1942/45654
ISSN: 1388-9842
e-ISSN: 1879-0844
DOI: 10.1002/ejhf.3618
ISI #: 001433452800001
Rights: 2025 European Society of Cardiology
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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