Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/45689
Title: | Tafamidis in octogenarians with wild-type transthyretin cardiac amyloidosis: an international cohort study | Authors: | Debonnaire, Philippe Dujardin, Karl Verheyen, Nicolas Pouleur, Anne-Catherine Droogmans, Steven Claeys, Mathias Bohyn, Alexandre BOGAERTS, Kris El Haddad, Milad Christiaen, Emma Wyseure, Nicolas Zach, David K. Buytaert, Lars Jacobs , Annemie Buysschaert, Ian Trenson, Sander Van Hoeyweghen, Raf Tavernier, Rene |
Issue Date: | 2025 | Publisher: | OXFORD UNIV PRESS | Source: | European heart journal, 46 (11) , p. 1057 -1070 | Abstract: | Background and Aims In real-world, wild-type transthyretin cardiomyopathy is increasingly diagnosed in patients >= 80 years old (octogenarians), although being underrepresented in randomized clinical trials. Specific data on natural course and outcome under tafamidis treatment in octogenarians are therefore scarce. The impact of tafamidis treatment on mortality in real-world wild-type transthyretin cardiomyopathy octogenarians was studied. Methods An international, multicentre cohort study of 710 consecutive wild-type transthyretin cardiomyopathy patients with mean follow-up of 2.2 +/- 1.8 years for all-cause mortality endpoint was performed. Results The cohort consisted of 58.5% (415/710) octogenarians (85 +/- 4 years, 74.2% male). Before tafamidis availability, natural course in octogenarians (148/257) vs. non-octogenarians (109/257) was poor, with 16% 1-year and 71% 5-year mortality vs. 8% and 47%, respectively (P < .001). Since tafamidis availability, 70.1% (253/361) octogenarians were initiated on tafamidis vs. 83.7% (231/276) non-octogenarians (P < .001). Tafamidis discontinuation was similar (octogenarians 10.3% and non-octogenarians 7.4%; P = .260). Overall tafamidis treated vs. untreated octogenarians had better unadjusted survival (P < .001), with 5% 1-year and 24% 3-year mortality. Tafamidis treatment associated with lower mortality after propensity score matching on baseline variables, including age, National Amyloidosis Centre stage, and New York Heart Association class in on average 394 subjects [hazard ratio (HR) = 0.53, 95% confidence interval (CI) 0.34-0.84, P = .007], also in octogenarians (HR = 0.57, 95% CI 0.33-1.01, P = .053). Neither age at diagnosis (P = .217) nor at treatment initiation (P = .154) interacted with tafamidis mortality benefit. Octogenarians had poorer survival despite tafamidis, when initiated at >= 90 years (HR = 3.3, 95% CI 1.10-9.53, P = .033) and National Amyloidosis Centre Stage >= 3 (HR = 2.4, 95% CI 0.87-6.46, P = .090). Conclusions Real-world tafamidis treatment improves survival without age affecting treatment efficacy, although mortality remains considerable in octogenarians. | Notes: | Debonnaire, P (corresponding author), AZ Sint Jan Brugge, Dept Cardiol, Ruddershove 10, B-8000 Brugge, Belgium. philippe.debonnaire@azsintjan.be |
Keywords: | Octogenarian;Tafamidis;Transthyretin;Cardiac amyloidosis;Cardiomyopathy;Mortality | Document URI: | http://hdl.handle.net/1942/45689 | ISSN: | 0195-668X | e-ISSN: | 1522-9645 | DOI: | 10.1093/eurheartj/ehae923 | ISI #: | 001437274900001 | Rights: | The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tafamidis in octogenarians with wild-type transthyretin cardiac amyloidosis_ an international cohort study.pdf | Published version | 1.57 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.