Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/45805
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dc.contributor.authorWindster, Jonathan D-
dc.contributor.authorKakiailatu, Naomi J M-
dc.contributor.authorKuil, Laura E-
dc.contributor.authorAntanaviciute, Agne-
dc.contributor.authorSacchetti, Andrea-
dc.contributor.authorMacKenzie, Katherine C-
dc.contributor.authorPeulen-Zink, Joke-
dc.contributor.authorKan, Tsung W-
dc.contributor.authorBindels, Eric-
dc.contributor.authorde Pater, Emma-
dc.contributor.authorDoukas, Michael-
dc.contributor.authorvan den Bosch, Thierry P P-
dc.contributor.authorYousefi, Soheil-
dc.contributor.authorBarakat, Tahsin-Stefan-
dc.contributor.authorMeeussen, Conny J H M-
dc.contributor.authorSloots, Pim C E J-
dc.contributor.authorWijnen, Renee M H-
dc.contributor.authorParikh, Kaushal-
dc.contributor.authorBOESMANS, Werend-
dc.contributor.authorMelotte , Veerle-
dc.contributor.authorHofstra, Robert M W-
dc.contributor.authorSimmons, Alison-
dc.contributor.authorAlves, Maria M-
dc.date.accessioned2025-04-03T12:40:04Z-
dc.date.available2025-04-03T12:40:04Z-
dc.date.issued2024-
dc.date.submitted2025-03-25T15:16:50Z-
dc.identifier.citationGastroenterology,-
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/1942/45805-
dc.description.abstractThe enteric nervous system (ENS), which is composed of neurons and glia, regulates intestinal motility. Hirschsprung disease (HSCR) results from defects in ENS formation; however, although neuronal aspects have been studied extensively, enteric glia remain disregarded. This study aimed to explore enteric glia diversity in health and disease.-
dc.description.sponsorshipTahsin-Stefan Barakat was supported by the Netherlands Organisation for Scientific Research (ZonMw Vidi, grant 09150172110002), an Erasmus Medical Center Fellowship 2017, and Erasmus Medical Center Human Disease Model Award 2018. Veerle Melotte was supported by the Netherlands Organisation for Scientific Research (ZonMw Vidi, grant). Naomi J. M. Kakiailatu and Maria M. Alves were supported by the Sophia Foundation of the Erasmus MC-Sophia Kinderziekenhuis (S17-18; S20-63; S22-76). Funding bodies did not have any influence on study design, results and data interpretation, or final manuscript. Acknowledgments The authors dedicate this work to the memory of Prof Robert M. W. Hofstra. His passion for genetics and functional research was an inspiration to all of us. We are deeply grateful for his friendship, guidance, and mentorship. The authors thank R. M. Hoogenboezem (Department of Hematology, Erasmus Medical Center Cancer Institute) for processing the raw single-cell data and the Optical Imaging Center of the Erasmus Medical Center for maintenance and assistance with the use of confocal microscopes. The authors would also like to thank R. P. Kapur (Department of Pathology, University of Seattle), W. El-Nachef, M. P. Verhagen (Department of Pathology, Erasmus Medical Center), O. J. M. Schäffers (Department Reproduction and Development), and A. J. Burns for insightful discussions.-
dc.language.isoen-
dc.rights© 2025 The Author(s). Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).-
dc.subject.otherENS-
dc.subject.otherEnteric Glia-
dc.subject.otherHirschsprung Disease-
dc.subject.otherPrucalopride-
dc.subject.otherSchwann Cells-
dc.subject.otherSingle-Cell RNA Sequencing-
dc.titleHuman Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease-
dc.typeJournal Contribution-
dc.identifier.epage979.e12-
dc.identifier.issue5-
dc.identifier.spage965-
dc.identifier.volume168-
local.format.pages27-
local.bibliographicCitation.jcatA2-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.statusIn press-
dc.identifier.doi10.1053/j.gastro.2024.12.011-
dc.identifier.pmid39725172-
dc.identifier.isi001492939400001-
local.provider.typePubMed-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.contributorWindster, Jonathan D-
item.contributorKakiailatu, Naomi J M-
item.contributorKuil, Laura E-
item.contributorAntanaviciute, Agne-
item.contributorSacchetti, Andrea-
item.contributorMacKenzie, Katherine C-
item.contributorPeulen-Zink, Joke-
item.contributorKan, Tsung W-
item.contributorBindels, Eric-
item.contributorde Pater, Emma-
item.contributorDoukas, Michael-
item.contributorvan den Bosch, Thierry P P-
item.contributorYousefi, Soheil-
item.contributorBarakat, Tahsin-Stefan-
item.contributorMeeussen, Conny J H M-
item.contributorSloots, Pim C E J-
item.contributorWijnen, Renee M H-
item.contributorParikh, Kaushal-
item.contributorBOESMANS, Werend-
item.contributorMelotte , Veerle-
item.contributorHofstra, Robert M W-
item.contributorSimmons, Alison-
item.contributorAlves, Maria M-
item.fullcitationWindster, Jonathan D; Kakiailatu, Naomi J M; Kuil, Laura E; Antanaviciute, Agne; Sacchetti, Andrea; MacKenzie, Katherine C; Peulen-Zink, Joke; Kan, Tsung W; Bindels, Eric; de Pater, Emma; Doukas, Michael; van den Bosch, Thierry P P; Yousefi, Soheil; Barakat, Tahsin-Stefan; Meeussen, Conny J H M; Sloots, Pim C E J; Wijnen, Renee M H; Parikh, Kaushal; BOESMANS, Werend; Melotte , Veerle; Hofstra, Robert M W; Simmons, Alison & Alves, Maria M (2024) Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease. In: Gastroenterology,.-
item.accessRightsClosed Access-
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