Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/46055
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dc.contributor.authorWintjens, Anne G. W. E.-
dc.contributor.authorFransen, Peter-Paul K. H.-
dc.contributor.authorLenaerts, Kaatje-
dc.contributor.authorLiu, Hong-
dc.contributor.authorAlmen, Geert C. van-
dc.contributor.authorGijbels, Marion J.-
dc.contributor.authorJanssen, Ben J. A.-
dc.contributor.authorHingh, Ignace H. J. T. de-
dc.contributor.authorDankers, Patricia Y. W.-
dc.contributor.authorVAN DER SPEETEN, Kurt-
dc.contributor.authorBouvy, Nicole D.-
dc.contributor.authorMARCHAL, Wouter-
dc.date.accessioned2025-05-26T07:17:31Z-
dc.date.available2025-05-26T07:17:31Z-
dc.date.issued2025-
dc.date.submitted2025-05-22T15:43:50Z-
dc.identifier.citationJournal of controlled release, 383 (Art N° 113763)-
dc.identifier.urihttp://hdl.handle.net/1942/46055-
dc.description.abstractObjective: This study evaluates the pharmacokinetics of an ureido-pyrimidinone poly(ethylene) glycol (UPy-PEG) hydrogel loaded with mitomycin C (MMC) in rats. The hydrogel aims to enhance the intraperitoneal residence time of MMC, potentially improving therapeutic outcomes for peritoneal metastases (PM) patients. Methods: Rats were divided into two groups: h-MMC (n = 8), receiving MMC encapsulated in hydrogel, and pbsMMC (n = 6), receiving MMC in PBS. Blood samples were collected from 5 min to 48 h post-administration. MMC concentrations were measured using LC-ESI-MS. Systemic and local adverse effects were assessed through blood analysis and post-mortem histopathology. Results: The hydrogel prolonged detectable plasma MMC levels: 24 h for h-MMC vs. 4 h for pbs-MMC. h-MMC had a Cmax of 120 f 21 mu g/L and a Tmax of 52.5 f 8.2 min; pbs-MMC had a Cmax of 358 f 24 mu g/L and a Tmax of 37.5 f 8.2 min. The area under the curve ratio of h-MMC/pbs-MMC was 87 %. Platelet counts were significantly lower in h-MMC at 24- and 48 h and in pbs-MMC at 48 h. No liver or kidney damage was observed, though vacuolated macrophages were noted in the hydrogel-treated groups. Conclusion: The hydrogel effectively prolonged MMC presence in plasma, suggesting extended intraperitoneal residence time and supporting previous findings of therapeutic effectiveness in a PM rat model.-
dc.description.sponsorshipThe authors acknowledge the funding of the Dutch Cancer Society (project number 12055) and the support of the partners of Regenerative Medicine Crossing Borders (RegMed XB), powered by Health ~ Holland, Top Sector Life Sciences & Health and the Dutch Ministry of Education, Culture and Science for the Gravitation Programs (024.003.013 and 024.005.020). Patricia Dankers, Peter-Paul Fransen, and Geert van Almen are co-founders and hold shares of UPyTher BV. Ignace de Hingh receives an unrestricted research funding from Rand and ROCHE, both paid to the institute (Maastricht University).-
dc.language.isoen-
dc.publisherELSEVIER-
dc.rights2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).-
dc.subject.otherMitomycin C-
dc.subject.otherLC-ESI-MS-
dc.subject.otherPharmacokinetics-
dc.subject.otherUPy-PEG-
dc.subject.otherDrug delivery system-
dc.titleThe pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model-
dc.typeJournal Contribution-
dc.identifier.volume383-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notesBouvy, ND (corresponding author), Maastricht Univ, Dept Surg, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands.-
dc.description.notesn.bouvy@mumc.nl-
local.publisher.placeRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr113763-
dc.identifier.doi10.1016/j.jconrel.2025.113763-
dc.identifier.pmid40274069-
dc.identifier.isi001483080200001-
dc.contributor.orcidLenaerts, Kaatje/0000-0002-9858-0538-
local.provider.typewosris-
local.description.affiliation[Wintjens, Anne G. W. E.; Lenaerts, Kaatje; Liu, Hong; Bouvy, Nicole D.] Maastricht Univ, Dept Surg, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands.-
local.description.affiliation[Wintjens, Anne G. W. E.; Lenaerts, Kaatje; Liu, Hong; Gijbels, Marion J.] Maastricht Univ, NUTRIM Inst Nutr & Translat Res Metab, Maastricht, Netherlands.-
local.description.affiliation[Fransen, Peter-Paul K. H.; Almen, Geert C. van] UPyTher BV, Eindhoven, Netherlands.-
local.description.affiliation[Gijbels, Marion J.] Maastricht Univ, Dept Pathol, Med Ctr, Maastricht, Netherlands.-
local.description.affiliation[Gijbels, Marion J.] Univ Amsterdam, Amsterdam Cardiovasc Sci, Dept Med Biochem,Expt Vasc Biol, Amsterdam Infect & Immun,Med Ctr, Amsterdam, Netherlands.-
local.description.affiliation[Janssen, Ben J. A.] Maastricht Univ, Dept Pharmacol & Toxicol, Maastricht, Netherlands.-
local.description.affiliation[Hingh, Ignace H. J. T. de; Bouvy, Nicole D.] Maastricht Univ, Sch Oncol & Reprod, GROW, Maastricht, Netherlands.-
local.description.affiliation[Hingh, Ignace H. J. T. de] Catharina Hosp, Dept Surg, Eindhoven, Netherlands.-
local.description.affiliation[Dankers, Patricia Y. W.] Eindhoven Univ Technol, Inst Complex Mol Syst, Eindhoven, Netherlands.-
local.description.affiliation[Fransen, Peter-Paul K. H.; Dankers, Patricia Y. W.] Eindhoven Univ Technol, Dept Biomed Engn, Lab Chem Biol, Eindhoven, Netherlands.-
local.description.affiliation[van der Speeten, Kurt; Marchal, Wouter] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Discipline Grp Physiol Biochem & Immunol, Hasselt, Belgium.-
local.description.affiliation[van der Speeten, Kurt; Marchal, Wouter] Hasselt Univ, Transnatl Univ Limburg, Hasselt, Belgium.-
local.description.affiliation[van der Speeten, Kurt] Hosp Oost Limburg, Dept Surg Oncol, Genk, Belgium.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.fullcitationWintjens, Anne G. W. E.; Fransen, Peter-Paul K. H.; Lenaerts, Kaatje; Liu, Hong; Almen, Geert C. van; Gijbels, Marion J.; Janssen, Ben J. A.; Hingh, Ignace H. J. T. de; Dankers, Patricia Y. W.; VAN DER SPEETEN, Kurt; Bouvy, Nicole D. & MARCHAL, Wouter (2025) The pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model. In: Journal of controlled release, 383 (Art N° 113763).-
item.accessRightsOpen Access-
item.contributorWintjens, Anne G. W. E.-
item.contributorFransen, Peter-Paul K. H.-
item.contributorLenaerts, Kaatje-
item.contributorLiu, Hong-
item.contributorAlmen, Geert C. van-
item.contributorGijbels, Marion J.-
item.contributorJanssen, Ben J. A.-
item.contributorHingh, Ignace H. J. T. de-
item.contributorDankers, Patricia Y. W.-
item.contributorVAN DER SPEETEN, Kurt-
item.contributorBouvy, Nicole D.-
item.contributorMARCHAL, Wouter-
crisitem.journal.issn0168-3659-
crisitem.journal.eissn1873-4995-
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