Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/46365
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dc.contributor.authorRangelova, E.-
dc.contributor.authorStoop, T. F.-
dc.contributor.authorvan Ramshorst, T. M. E.-
dc.contributor.authorAli, M.-
dc.contributor.authorvan Bodegraven, E. A.-
dc.contributor.authorJaved , A. A.-
dc.contributor.authorHashimoto, D.-
dc.contributor.authorSteyerberg, E.-
dc.contributor.authorBanerjee, A.-
dc.contributor.authorJain, A.-
dc.contributor.authorSauvanet, A.-
dc.contributor.authorSerrablo, A.-
dc.contributor.authorGiani, A.-
dc.contributor.authorGiardino, A.-
dc.contributor.authorZerbi, A.-
dc.contributor.authorArshad, A.-
dc.contributor.authorWijma, A. G.-
dc.contributor.authorCoratti, A.-
dc.contributor.authorZironda, A.-
dc.contributor.authorSocratous, A.-
dc.contributor.authorRojas, A.-
dc.contributor.authorHalimi, A.-
dc.contributor.authorEjaz, A.-
dc.contributor.authorOba, A.-
dc.contributor.authorPatel, B. Y.-
dc.contributor.authorBjornsson, B.-
dc.contributor.authorReames, B. N.-
dc.contributor.authorTingstedt, B.-
dc.contributor.authorGoh, B. K. P.-
dc.contributor.authorPaya-Llorente, C.-
dc.contributor.authorDel Pozo, C. D.-
dc.contributor.authorGonzalez-Abos, C.-
dc.contributor.authorMedin, C.-
dc.contributor.authorvan Eijck, C. H. J.-
dc.contributor.authorde Ponthaud, C.-
dc.contributor.authorTakishita, C.-
dc.contributor.authorSchwabl, C.-
dc.contributor.authorMansson, C.-
dc.contributor.authorRicci, C.-
dc.contributor.authorThiels, C. A.-
dc.contributor.authorDouchi, D.-
dc.contributor.authorHughes, D. L.-
dc.contributor.authorKilburn, D.-
dc.contributor.authorFlanking, D.-
dc.contributor.authorKleive, D.-
dc.contributor.authorSilva, D. S.-
dc.contributor.authorEdil, B. H.-
dc.contributor.authorPando, E.-
dc.contributor.authorMoltzer, E.-
dc.contributor.authorKauffman, E. F.-
dc.contributor.authorWarren, E.-
dc.contributor.authorBozkurt, E.-
dc.contributor.authorSparrelid, E.-
dc.contributor.authorThoma, E.-
dc.contributor.authorVerkolf, E.-
dc.contributor.authorAusania, F.-
dc.contributor.authorGiannone, F.-
dc.contributor.authorHuttner, F. J.-
dc.contributor.authorBurdio, F.-
dc.contributor.authorSouche, F. R.-
dc.contributor.authorBerrevoet, F.-
dc.contributor.authorDaams, F.-
dc.contributor.authorMotoi, F.-
dc.contributor.authorSaliba, G.-
dc.contributor.authorKazemier, G.-
dc.contributor.authorRoeyen, G.-
dc.contributor.authorNappo, G.-
dc.contributor.authorButturini, G.-
dc.contributor.authorFerrari, G.-
dc.contributor.authorFusai, G. Kito-
dc.contributor.authorHonda, G.-
dc.contributor.authorSERGEANT, Gregory-
dc.contributor.authorKarteszi, H.-
dc.contributor.authorTakami, H.-
dc.contributor.authorSuto, H.-
dc.contributor.authorMatsumoto, I.-
dc.contributor.authorMora-Oliver, I.-
dc.contributor.authorFrigerio, I.-
dc.contributor.authorFabre, J. M.-
dc.contributor.authorChen, J.-
dc.contributor.authorSham, J. G.-
dc.contributor.authorDavide, J.-
dc.contributor.authorUrdzik, J.-
dc.contributor.authorde Martino, J.-
dc.contributor.authorNielsen, K.-
dc.contributor.authorOkano, K.-
dc.contributor.authorKamei, K.-
dc.contributor.authorOkada, K.-
dc.contributor.authorTanaka, K.-
dc.contributor.authorLabori, K. J.-
dc.contributor.authorGoodsell, K. E.-
dc.contributor.authorAlberici, L.-
dc.contributor.authorWebber, L.-
dc.contributor.authorKirkov, L.-
dc.contributor.authorde Franco, L.-
dc.contributor.authorMiyashita, M.-
dc.contributor.authorMaglione, M.-
dc.contributor.authorGramellini, M.-
dc.contributor.authorRamera, M.-
dc.contributor.authorAmaral, M. J.-
dc.contributor.authorRamaekers, M.-
dc.contributor.authorTruty, M. J.-
dc.contributor.authorvan Dam, M. A.-
dc.contributor.authorStommel, M. W. J.-
dc.contributor.authorPetrikowski, M.-
dc.contributor.authorImamura, M.-
dc.contributor.authorHayashi, M.-
dc.contributor.authorD'Hondt, M.-
dc.contributor.authorBrunner, M.-
dc.contributor.authorHogg, M. E.-
dc.contributor.authorZhang, C.-
dc.contributor.authorSuarez-Munoz, M. A.-
dc.contributor.authorLuyer, M. D.-
dc.contributor.authorUnno, M.-
dc.contributor.authorMizuma, M.-
dc.contributor.authorJanot, M.-
dc.contributor.authorSahakyan, M. A.-
dc.contributor.authorJamieson, N. B.-
dc.contributor.authorBusch, O. R.-
dc.contributor.authorBilge, O.-
dc.contributor.authorBelyaev, O.-
dc.contributor.authorFranklin, O.-
dc.contributor.authorSanchez-Velazquez, P.-
dc.contributor.authorPessaux, P.-
dc.contributor.authorHolka, P. S.-
dc.contributor.authorGhorbani, P.-
dc.contributor.authorCasadei, R.-
dc.contributor.authorSartoris, R.-
dc.contributor.authorSchulick, R. D.-
dc.contributor.authorGrutzmann, R.-
dc.contributor.authorSutcliffe, R.-
dc.contributor.authorMata, R.-
dc.contributor.authorPatel, R. B.-
dc.contributor.authorTakahashi, R.-
dc.contributor.authorFranco, S. Rodriguez-
dc.contributor.authorCabus, S. S.-
dc.contributor.authorHirano, S.-
dc.contributor.authorGaujoux, S.-
dc.contributor.authorFesten, S.-
dc.contributor.authorKozono, S.-
dc.contributor.authorMaithel, S. K.-
dc.contributor.authorChai, S. M.-
dc.contributor.authorYamaki, S.-
dc.contributor.authorvan Laarhoven, S.-
dc.contributor.authorMieog, J. S. D.-
dc.contributor.authorMurakami, T.-
dc.contributor.authorCodjia, T.-
dc.contributor.authorSumiyoshi, T.-
dc.contributor.authorKarsten, T. M.-
dc.contributor.authorNakamura, T.-
dc.contributor.authorSugawara, T.-
dc.contributor.authorBoggi, U.-
dc.contributor.authorHartman, V.-
dc.contributor.authorde Meijer, V. E.-
dc.contributor.authorBartholoma, W.-
dc.contributor.authorKwon, W.-
dc.contributor.authorKoh, Y. X.-
dc.contributor.authorCho, Y.-
dc.contributor.authorTakeyama, Y.-
dc.contributor.authorInoue, Y.-
dc.contributor.authorNagakawa, Y.-
dc.contributor.authorKawamoto, Y.-
dc.contributor.authorOme, Y.-
dc.contributor.authorSoonawalla, Z.-
dc.contributor.authorUemura, K.-
dc.contributor.authorWolfgang, C. L.-
dc.contributor.authorJang, J. Y.-
dc.contributor.authorPadbury, R.-
dc.contributor.authorSatoi, S.-
dc.contributor.authorMessersmith, W.-
dc.contributor.authorWilmink, J. W.-
dc.contributor.authorAbu Hilal, M.-
dc.contributor.authorBesselink, M. G.-
dc.contributor.authorDel Chiaro, M.-
dc.date.accessioned2025-07-22T12:49:51Z-
dc.date.available2025-07-22T12:49:51Z-
dc.date.issued2025-
dc.date.submitted2025-06-27T10:36:37Z-
dc.identifier.citationAnnals of oncology, 36 (5) , p. 529 -542-
dc.identifier.urihttp://hdl.handle.net/1942/46365-
dc.description.abstractBackground: Left-sided pancreatic cancer is associated with worse overall survival (OS) compared with right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with resectable pancreatic cancer (RPC), current randomized trials included mostly patients with right-sided RPC. The purpose of this study was to assess the association between neoadjuvant therapy and OS in patients with left-sided RPC compared with upfront surgery. Patients and methods: This was an international multicenter retrospective study including consecutive patients after left-sided pancreatic resection for pathology-proven RPC, either after neoadjuvant therapy or upfront surgery in 76 centers from 18 countries on 4 continents (2013-2019). The primary endpoint was OS from diagnosis. Time-dependent Cox regression analysis was carried out to investigate the association of neoadjuvant therapy with OS, adjusting for confounders at the time of diagnosis. Adjusted OS probabilities were calculated. Results: Overall, 2282 patients after left-sided pancreatic resection for RPC were included of whom 290 patients (13%) received neoadjuvant therapy. The most common neoadjuvant regimens were (m)FOLFIRINOX (38%) and gemcitabine-nab-paclitaxel (22%). After upfront surgery, 72% of patients received adjuvant chemotherapy, mostly a single-agent regimen (74%). Neoadjuvant therapy was associated with prolonged OS compared with upfront surgery (adjusted hazard ratio 0.69, 95% confidence interval 0.58-0.83) with an adjusted median OS of 53 versus 37 months (P = 0.0003) and adjusted 5-year OS rates of 47% versus 35% (P = 0.0001) compared with upfront surgery. Interaction analysis demonstrated a stronger effect of neoadjuvant therapy in patients with a larger tumor (P-interaction = 0.003) and higher serum carbohydrate antigen 19-9 (CA19-9; P-interaction = 0.005). In contrast, the effect of neoadjuvant therapy was not enhanced for splenic artery (P-interaction = 0.43), splenic vein (P-interaction = 0.30), retroperitoneal (P-interaction = 0.84), and multivisceral (P-interaction = 0.96) involvement. Conclusions: Neoadjuvant therapy in patients with left-sided RPC was associated with improved OS compared with upfront surgery. The impact of neoadjuvant therapy increased with larger tumor size and higher serum CA19-9 at diagnosis. Randomized controlled trials on neoadjuvant therapy specifically in patients with left-sided RPC are needed.-
dc.language.isoen-
dc.publisherELSEVIER-
dc.rights2025 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).-
dc.subject.otherpancreatic adenocarcinoma-
dc.subject.otherpancreatic body/tail-
dc.subject.otherresectable-
dc.subject.otherneoadjuvant therapy-
dc.subject.otherCA19-9-
dc.subject.othertumor size-
dc.titleThe impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study-
dc.typeJournal Contribution-
dc.identifier.epage542-
dc.identifier.issue5-
dc.identifier.spage529-
dc.identifier.volume36-
local.format.pages14-
local.bibliographicCitation.jcatA1-
dc.description.notesRangelova, E (corresponding author), Univ Gotenborg, Sahlgrenska Acad, Inst Clin Sci, Dept Upper Abdominal Surg, Bla Straket 5, S-41345 Gothenburg, Sweden.-
dc.description.noteselena.rangelova@gu.se-
local.publisher.placeRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1016/j.annonc.2024.12.015-
dc.identifier.pmid39814200-
dc.identifier.isi001498312500001-
dc.contributor.orcidSUAREZ MUNOZ, MIGUEL ANGEL/0000-0001-9012-8670; Labori, Knut-
dc.contributor.orcidJorgen/0000-0001-6777-7955; Hashimoto, Daisuke/0000-0002-7880-889X; Ali,-
dc.contributor.orcidMahsoem/0000-0002-0511-6323; Stoop, Thomas F./0000-0003-3328-4516;-
dc.contributor.orcidDomingo Del Pozo, Carlos/0000-0003-4499-3019; Petrikowski,-
dc.contributor.orcidMarvin/0009-0000-8665-0925; Tufekci, Tutku/0000-0001-9083-2158;-
dc.contributor.orcidSanchez-Velazquez, Patricia/0000-0002-7902-3920; Wijma, Allard-
dc.contributor.orcidGeert/0000-0003-4227-4715; Javed, Ammar/0000-0002-5463-5250; Pando,-
dc.contributor.orcidElizabeth/0000-0001-6898-5502-
local.provider.typewosris-
local.description.affiliation[Rangelova, E.; Socratous, A.; Flanking, D.] Sahlgrens Univ Hosp, Dept Upper Abdominal Surg, Gothenburg, Sweden.-
local.description.affiliation[Rangelova, E.; Socratous, A.] Univ Gothenburg, Inst Clin Sci, Dept Surg, Sahlgrenska Acad, Gothenburg, Sweden.-
local.description.affiliation[Stoop, T. F.; van Ramshorst, T. M. E.; van Bodegraven, E. A.; Javed, A. A.; Busch, O. R.; Besselink, M. G.] Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.-
local.description.affiliation[Stoop, T. F.; van Ramshorst, T. M. E.; Ali, M.; van Bodegraven, E. A.; Javed, A. A.; Daams, F.; Kazemier, G.; Busch, O. R.; Wilmink, J. W.; Besselink, M. G.] Canc Ctr Amsterdam, Amsterdam, Netherlands.-
local.description.affiliation[Stoop, T. F.; Oba, A.; Franklin, O.; Schulick, R. D.; Franco, S. Rodriguez; Sugawara, T.; Satoi, S.; Del Chiaro, M.] Univ Colorado, Sch Med, Dept Surg, Div Surg Oncol, Anschutz Med Campus, Aurora, CO USA.-
local.description.affiliation[van Ramshorst, T. M. E.; Ramera, M.] Fdn Poliambulanza, Inst Osped, Dept Surg, Brescia, Italy.-
local.description.affiliation[Ali, M.; Daams, F.; Kazemier, G.] Vrije Univ, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.-
local.description.affiliation[Javed, A. A.; Wolfgang, C. L.] NYU, Med Ctr, Dept Surg, Dept Surg Oncol, New York, NY USA.-
local.description.affiliation[Hashimoto, D.; Satoi, S.] Kansai Med Univ, Dept Surg, Osaka, Japan.-
local.description.affiliation[Steyerberg, E.] Leiden Univ, Med Ctr, Dept Biomed Data Sci, Leiden, Netherlands.-
local.description.affiliation[Banerjee, A.; Fusai, G. Kito] Royal Free Hosp, HPB & Liver Transplant Unit, London, England.-
local.description.affiliation[Jain, A.; Edil, B. H.] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Div Surg Oncol, Oklahoma City, OK USA.-
local.description.affiliation[Sauvanet, A.] Univ Paris Cite, Beaujon Hosp, APHP, Dept HPB Surg & Liver Transplantat, Clichy, France.-
local.description.affiliation[Serrablo, A.] Miguel Servet Univ Hosp, HPB Surg Div, Zaragoza, Spain.-
local.description.affiliation[Giani, A.; Ferrari, G.] ASST Grande Osped Metropolitano Niguarda, Div Minimally Invas Surg Oncol, Milan, Italy.-
local.description.affiliation[Giardino, A.; Butturini, G.; Frigerio, I.; Abu Hilal, M.] Pederzoli Hosp, Dept HPB Surg, Peschiera Del Garda, Peschiera, Italy.-
local.description.affiliation[Zerbi, A.; Nappo, G.; Gramellini, M.] Humanitas Univ, Dept Biomed Sci, Milan, Italy.-
local.description.affiliation[Zerbi, A.; Nappo, G.; Gramellini, M.] IRCCS, Humanitas Clin & Res Ctr, Pancreat Surg Unit, Milan, Italy.-
local.description.affiliation[Arshad, A.; Patel, B. Y.] Univ Hosp Southampton NHS Trust, Southampton Gen Hosp, Hepatopancreatobiliary Unit, Southampton, Hants, England.-
local.description.affiliation[Wijma, A. G.; de Meijer, V. E.] Univ Groningen, Dept Surg, Groningen, Netherlands.-
local.description.affiliation[Wijma, A. G.] Univ Med Ctr Groningen, Groningen, Netherlands.-
local.description.affiliation[Coratti, A.; de Franco, L.] Azienda USL Toscana Sud Est, Misericordia Hosp, Gen & Emergency Surg Unit, Grosseto, Italy.-
local.description.affiliation[Zironda, A.; Thiels, C. A.; Truty, M. J.] Mayo Clin, Div Hepatobiliary & Pancreas Surg, Rochester, MN USA.-
local.description.affiliation[Rojas, A.; Hogg, M. E.] NorthShore Univ Hlth Syst, Dept Surg, Evanston, IL USA.-
local.description.affiliation[Halimi, A.; Franklin, O.] Umea Univ, Dept Surg, Umea, Sweden.-
local.description.affiliation[Halimi, A.; Sparrelid, E.; Saliba, G.; Ghorbani, P.] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg & Oncol, Stockholm, Sweden.-
local.description.affiliation[Ejaz, A.; Patel, R. B.] Ohio State Univ, Dept Surg, Div Surg Oncol, Columbus, OH USA.-
local.description.affiliation[Oba, A.; Sugawara, T.] Tokyo Med & Dent Univ, Grad Sch Med, Dept Hepatobiliary & Pancreat Surg, Tokyo, Japan.-
local.description.affiliation[Oba, A.; Miyashita, M.; Inoue, Y.] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Hepatobiliary & Pancreat Surg, Tokyo, Japan.-
local.description.affiliation[Bjornsson, B.] Linkoping Univ Hosp, Dept Surg, Linkoping, Sweden.-
local.description.affiliation[Reames, B. N.; Zhang, C.] Univ Nebraska Med Ctr, Dept Surg, Omaha, NE USA.-
local.description.affiliation[Tingstedt, B.; Holka, P. S.] Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Lund, Sweden.-
local.description.affiliation[Goh, B. K. P.; Koh, Y. X.] Singapore Gen Hosp, Dept Hepatopancreatobiliary & Transplant Surg, Singapore, Singapore.-
local.description.affiliation[Goh, B. K. P.; Koh, Y. X.] Natl Canc Ctr Singapore, Singapore, Singapore.-
local.description.affiliation[Paya-Llorente, C.; Del Pozo, C. D.] Hosp Doctor Peset, Gen & Digest Surg, Valencia, Spain.-
local.description.affiliation[Gonzalez-Abos, C.; Ausania, F.] Hosp Clin Barcelona, Hepatobiliopancreat Dept, Barcelona, Spain.-
local.description.affiliation[Medin, C.; Warren, E.; Maithel, S. K.] Emory Univ, Winship Canc Inst, Div Surg Oncol, Atlanta, GA USA.-
local.description.affiliation[van Eijck, C. H. J.; Verkolf, E.] Erasmus MC Canc Inst, Dept Surg, Rotterdam, Netherlands.-
local.description.affiliation[de Ponthaud, C.; de Martino, J.; Gaujoux, S.] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Hepatobiliary & Pancreat Surg & Liver Transp, Paris, France.-
local.description.affiliation[Takishita, C.; Kozono, S.; Nagakawa, Y.] Tokyo Med Univ, Dept Gastrointestinal & Pediat Surg, Tokyo, Japan.-
local.description.affiliation[Schwabl, C.] Med Univ Innsbruck, Dept Radiol, Innsbruck, Austria.-
local.description.affiliation[Mansson, C.; Urdzik, J.; Alberici, L.] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.-
local.description.affiliation[Ricci, C.; Alberici, L.; Casadei, R.] Alma Mater Studiorum Univ Bologna, Dept Internal Med & Surg DIMEC, Bologna, Italy.-
local.description.affiliation[Ricci, C.; Casadei, R.] Azienda Osped Univ Bologna, IRCCS, Div Pancreat Surg, Bologna, Italy.-
local.description.affiliation[Douchi, D.; Unno, M.; Mizuma, M.] Tohoku Univ, Dept Surg, Sendai, Miyagi, Japan.-
local.description.affiliation[Hughes, D. L.; Soonawalla, Z.] Oxford Radcliffe Hosp NHS Fdn Trust, Dept Hepatobiliary & Pancreat Surg, Oxford, England.-
local.description.affiliation[Kilburn, D.; Chen, J.; Padbury, R.] Flinders Med Ctr, Dept Surg, Adelaide, SA, Australia.-
local.description.affiliation[Kleive, D.] Oslo Univ Hosp, Dept Hepatopancreatobiliary Surg, Oslo, Norway.-
local.description.affiliation[Silva, D. S.; Davide, J.] Ctr Hosp Univ Santo Antonio, HEBIPA Surg, Porto, Portugal.-
local.description.affiliation[Pando, E.; Mata, R.] Univ Autonoma Barcelona, Barcelona, Spain.-
local.description.affiliation[Pando, E.; Mata, R.] Hosp Univ Vall dHebron, Dept Hepatopancreatobiliary & Transplant Surg, Barcelona, Spain.-
local.description.affiliation[Moltzer, E.; Stommel, M. W. J.] Radboud Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands.-
local.description.affiliation[Kauffman, E. F.; Boggi, U.] Univ Pisa, Div Gen & Transplant Surg, Pisa, Italy.-
local.description.affiliation[Bozkurt, E.; Bilge, O.] Koc Univ, Sch Med, Dept Gen Surg, Istanbul, Turkey.-
local.description.affiliation[Thoma, E.; Huttner, F. J.] Ulm Univ Hosp, Dept Gen & Visceral Surg, Ulm, Germany.-
local.description.affiliation[Ausania, F.] Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain.-
local.description.affiliation[Giannone, F.; Pessaux, P.] Univ Hosp Strasbourg, Dept Visceral & Digest Surg, Strasbourg, France.-
local.description.affiliation[Burdio, F.; Sanchez-Velazquez, P.] Hosp del Mar Barcelona, Dept Surg, Hepatobiliary & Pancreat Unit, Barcelona, Spain.-
local.description.affiliation[Burdio, F.; Sanchez-Velazquez, P.] Univ Pompeu Fabra, Hosp del Mar Res Inst IMIM, Barcelona, Spain.-
local.description.affiliation[Souche, F. R.; Fabre, J. M.; Kirkov, L.] Univ Montpellier, CHU Montpellier, Oncol & Minimally Invas Digest Surg, Montpellier, France.-
local.description.affiliation[Berrevoet, F.] Ghent Univ Hosp, Dept Gen & HPB Surg & Liver Transplantat, Ghent, Belgium.-
local.description.affiliation[Motoi, F.] Yamagata Univ, Dept Surg, Yamagata, Japan.-
local.description.affiliation[Roeyen, G.; Hartman, V.] Univ Hosp Antwerp, Dept HPB Endocrine & Transplantat Surg, Antwerp, Belgium.-
local.description.affiliation[Honda, G.; Kawamoto, Y.; Ome, Y.] Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Tokyo, Japan.-
local.description.affiliation[Sergeant, G.] Univ Hasselt, Jessa Hosp, Dept Abdominal Surg, Hasselt, Belgium.-
local.description.affiliation[Sergeant, G.] Univ Hasselt, Fac Med & Hlth Sci, Hasselt, Belgium.-
local.description.affiliation[Karteszi, H.] Univ Hosp Bristol & Weston NHS Fdn Trust, Dept Radiol, Bristol, Avon, England.-
local.description.affiliation[Takami, H.; Hayashi, M.] Nagoya Univ, Dept Gastroenterol Surg Surg 2, Nagoya, Aichi, Japan.-
local.description.affiliation[Suto, H.; Okano, K.] Kagawa Univ, Dept Gastroenterol Surg, Takamatsu, Kagawa, Japan.-
local.description.affiliation[Matsumoto, I.; Kamei, K.; Takeyama, Y.] Kindai Univ, Dept Surg, Osakasayama, Japan.-
local.description.affiliation[Mora-Oliver, I.] Hosp Clin Univ Valencia, Dept Surg, Liver & Pancreatobiliary Unit, Biomed Res Inst,INCLIVA, Valencia, Spain.-
local.description.affiliation[Sham, J. G.; Goodsell, K. E.] Univ Washington, Dept Surg, Seattle, WA USA.-
local.description.affiliation[Sham, J. G.] Fred Hutchinson Canc Res Ctr, Seattle, WA USA.-
local.description.affiliation[Nielsen, K.; Sutcliffe, R.] Univ Hosp Birmingham NHS Fdn Trust, Dept Hepatopancreatobiliary Surg, Birmingham, W Midlands, England.-
local.description.affiliation[Okada, K.; Sumiyoshi, T.; Uemura, K.] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Surg, Hiroshima, Japan.-
local.description.affiliation[Tanaka, K.; Hirano, S.; Nakamura, T.] Hokkaido Univ, Fac Med, Dept Gastroenterol Surg 2, Sapporo, Hokkaido, Japan.-
local.description.affiliation[Labori, K. J.] Oslo Univ Hosp, Dept Hepatopancreatobiliary Surg, Oslo, Norway.-
local.description.affiliation[Labori, K. J.] Univ Oslo, Inst Clin Med, Oslo, Norway.-
local.description.affiliation[Webber, L.] Fiona Stanley Hosp, Dept Upper GI Surg, Perth, WA, Australia.-
local.description.affiliation[Maglione, M.] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria.-
local.description.affiliation[Ramera, M.] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.-
local.description.affiliation[Amaral, M. J.] Ctr Hosp & Univ Coimbra, Gen Surg Dept, Coimbra, Portugal.-
local.description.affiliation[Amaral, M. J.] Univ Coimbra, Fac Med, Coimbra, Portugal.-
local.description.affiliation[Ramaekers, M.; Luyer, M. D.] Catharina Hosp, Dept Surg, Eindhoven, Netherlands.-
local.description.affiliation[van Dam, M. A.; Yamaki, S.; van Laarhoven, S.; Mieog, J. S. D.] Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.-
local.description.affiliation[Petrikowski, M.; Janot, M.; Belyaev, O.] Ruhr Univ Bochum, Dept Surg, St Josef Hosp, Bochum, Germany.-
local.description.affiliation[Imamura, M.; Murakami, T.] Sapporo Med Univ, Dept Surg Surg Oncol & Sci, Sapporo, Hokkaido, Japan.-
local.description.affiliation[D'Hondt, M.] Groeninge Hosp, Dept Digest & Hepatobiliarypancreat Surg, Kortrijk, Belgium.-
local.description.affiliation[Brunner, M.] Friedrich Alexander Univ Erlangen Nurnberg, Dept Surg, Univ Klinikum Erlangen, Erlangen, Germany.-
local.description.affiliation[Suarez-Munoz, M. A.] Univ Hosp Virgen de la Victoria, HPB Surg Unit, Malaga, Spain.-
local.description.affiliation[Sahakyan, M. A.; Grutzmann, R.] Oslo Univ Hosp, Rigshosp, Intervent Ctr, Oslo, Norway.-
local.description.affiliation[Jamieson, N. B.] Univ Glasgow, Sch Canc Sci, Wolfson Wohl Canc Res Ctr, Glasgow, Lanark, Scotland.-
local.description.affiliation[Sartoris, R.] Univ Paris Cite, Beaujon Hosp, APHP, Dept Radiol, Clichy, France.-
local.description.affiliation[Cabus, S. S.] Hosp Santa Creu & Sant Pau, Dept HPB Surg, Barcelona, Spain.-
local.description.affiliation[Festen, S.; Karsten, T. M.] OLVG, Dept Surg, Amsterdam, Netherlands.-
local.description.affiliation[Chai, S. M.] PathWest Lab Med, Dept Anat Pathol, Perth, WA, Australia.-
local.description.affiliation[Yamaki, S.; van Laarhoven, S.] Univ Hosp Bristol & Weston NHS Fdn Trust, Dept HPB Surg, Bristol, Avon, England.-
local.description.affiliation[Codjia, T.] Rouen Univ Hosp, Dept Digest Surg, Rouen, France.-
local.description.affiliation[Bartholoma, W.] Linkoping Univ, Dept Radiol, Linkoping, Sweden.-
local.description.affiliation[Kwon, W.; Cho, Y.; Jang, J. Y.] Seoul Natl Univ Hosp, Dept Surg, Seoul, South Korea.-
local.description.affiliation[Messersmith, W.] Univ Colorado, Sch Med, Dept Med, Div Med Oncol, Aurora, CO USA.-
local.description.affiliation[Wilmink, J. W.] Univ Amsterdam, Dept Med Oncol, Amsterdam UMC, Amsterdam, Netherlands.-
local.uhasselt.internationalyes-
item.fullcitationRangelova, E.; Stoop, T. F.; van Ramshorst, T. M. E.; Ali, M.; van Bodegraven, E. A.; Javed , A. A.; Hashimoto, D.; Steyerberg, E.; Banerjee, A.; Jain, A.; Sauvanet, A.; Serrablo, A.; Giani, A.; Giardino, A.; Zerbi, A.; Arshad, A.; Wijma, A. G.; Coratti, A.; Zironda, A.; Socratous, A.; Rojas, A.; Halimi, A.; Ejaz, A.; Oba, A.; Patel, B. Y.; Bjornsson, B.; Reames, B. N.; Tingstedt, B.; Goh, B. K. P.; Paya-Llorente, C.; Del Pozo, C. D.; Gonzalez-Abos, C.; Medin, C.; van Eijck, C. H. J.; de Ponthaud, C.; Takishita, C.; Schwabl, C.; Mansson, C.; Ricci, C.; Thiels, C. A.; Douchi, D.; Hughes, D. L.; Kilburn, D.; Flanking, D.; Kleive, D.; Silva, D. S.; Edil, B. H.; Pando, E.; Moltzer, E.; Kauffman, E. F.; Warren, E.; Bozkurt, E.; Sparrelid, E.; Thoma, E.; Verkolf, E.; Ausania, F.; Giannone, F.; Huttner, F. J.; Burdio, F.; Souche, F. R.; Berrevoet, F.; Daams, F.; Motoi, F.; Saliba, G.; Kazemier, G.; Roeyen, G.; Nappo, G.; Butturini, G.; Ferrari, G.; Fusai, G. Kito; Honda, G.; SERGEANT, Gregory; Karteszi, H.; Takami, H.; Suto, H.; Matsumoto, I.; Mora-Oliver, I.; Frigerio, I.; Fabre, J. M.; Chen, J.; Sham, J. G.; Davide, J.; Urdzik, J.; de Martino, J.; Nielsen, K.; Okano, K.; Kamei, K.; Okada, K.; Tanaka, K.; Labori, K. J.; Goodsell, K. E.; Alberici, L.; Webber, L.; Kirkov, L.; de Franco, L.; Miyashita, M.; Maglione, M.; Gramellini, M.; Ramera, M.; Amaral, M. J.; Ramaekers, M.; Truty, M. J.; van Dam, M. A.; Stommel, M. W. J.; Petrikowski, M.; Imamura, M.; Hayashi, M.; D'Hondt, M.; Brunner, M.; Hogg, M. E.; Zhang, C.; Suarez-Munoz, M. A.; Luyer, M. D.; Unno, M.; Mizuma, M.; Janot, M.; Sahakyan, M. A.; Jamieson, N. B.; Busch, O. R.; Bilge, O.; Belyaev, O.; Franklin, O.; Sanchez-Velazquez, P.; Pessaux, P.; Holka, P. S.; Ghorbani, P.; Casadei, R.; Sartoris, R.; Schulick, R. D.; Grutzmann, R.; Sutcliffe, R.; Mata, R.; Patel, R. B.; Takahashi, R.; Franco, S. Rodriguez; Cabus, S. S.; Hirano, S.; Gaujoux, S.; Festen, S.; Kozono, S.; Maithel, S. K.; Chai, S. M.; Yamaki, S.; van Laarhoven, S.; Mieog, J. S. D.; Murakami, T.; Codjia, T.; Sumiyoshi, T.; Karsten, T. M.; Nakamura, T.; Sugawara, T.; Boggi, U.; Hartman, V.; de Meijer, V. E.; Bartholoma, W.; Kwon, W.; Koh, Y. X.; Cho, Y.; Takeyama, Y.; Inoue, Y.; Nagakawa, Y.; Kawamoto, Y.; Ome, Y.; Soonawalla, Z.; Uemura, K.; Wolfgang, C. L.; Jang, J. Y.; Padbury, R.; Satoi, S.; Messersmith, W.; Wilmink, J. W.; Abu Hilal, M.; Besselink, M. G. & Del Chiaro, M. (2025) The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study. In: Annals of oncology, 36 (5) , p. 529 -542.-
item.fulltextWith Fulltext-
item.contributorRangelova, E.-
item.contributorStoop, T. F.-
item.contributorvan Ramshorst, T. M. E.-
item.contributorAli, M.-
item.contributorvan Bodegraven, E. A.-
item.contributorJaved , A. A.-
item.contributorHashimoto, D.-
item.contributorSteyerberg, E.-
item.contributorBanerjee, A.-
item.contributorJain, A.-
item.contributorSauvanet, A.-
item.contributorSerrablo, A.-
item.contributorGiani, A.-
item.contributorGiardino, A.-
item.contributorZerbi, A.-
item.contributorArshad, A.-
item.contributorWijma, A. G.-
item.contributorCoratti, A.-
item.contributorZironda, A.-
item.contributorSocratous, A.-
item.contributorRojas, A.-
item.contributorHalimi, A.-
item.contributorEjaz, A.-
item.contributorOba, A.-
item.contributorPatel, B. Y.-
item.contributorBjornsson, B.-
item.contributorReames, B. N.-
item.contributorTingstedt, B.-
item.contributorGoh, B. K. P.-
item.contributorPaya-Llorente, C.-
item.contributorDel Pozo, C. D.-
item.contributorGonzalez-Abos, C.-
item.contributorMedin, C.-
item.contributorvan Eijck, C. H. J.-
item.contributorde Ponthaud, C.-
item.contributorTakishita, C.-
item.contributorSchwabl, C.-
item.contributorMansson, C.-
item.contributorRicci, C.-
item.contributorThiels, C. A.-
item.contributorDouchi, D.-
item.contributorHughes, D. L.-
item.contributorKilburn, D.-
item.contributorFlanking, D.-
item.contributorKleive, D.-
item.contributorSilva, D. S.-
item.contributorEdil, B. H.-
item.contributorPando, E.-
item.contributorMoltzer, E.-
item.contributorKauffman, E. F.-
item.contributorWarren, E.-
item.contributorBozkurt, E.-
item.contributorSparrelid, E.-
item.contributorThoma, E.-
item.contributorVerkolf, E.-
item.contributorAusania, F.-
item.contributorGiannone, F.-
item.contributorHuttner, F. J.-
item.contributorBurdio, F.-
item.contributorSouche, F. R.-
item.contributorBerrevoet, F.-
item.contributorDaams, F.-
item.contributorMotoi, F.-
item.contributorSaliba, G.-
item.contributorKazemier, G.-
item.contributorRoeyen, G.-
item.contributorNappo, G.-
item.contributorButturini, G.-
item.contributorFerrari, G.-
item.contributorFusai, G. Kito-
item.contributorHonda, G.-
item.contributorSERGEANT, Gregory-
item.contributorKarteszi, H.-
item.contributorTakami, H.-
item.contributorSuto, H.-
item.contributorMatsumoto, I.-
item.contributorMora-Oliver, I.-
item.contributorFrigerio, I.-
item.contributorFabre, J. M.-
item.contributorChen, J.-
item.contributorSham, J. G.-
item.contributorDavide, J.-
item.contributorUrdzik, J.-
item.contributorde Martino, J.-
item.contributorNielsen, K.-
item.contributorOkano, K.-
item.contributorKamei, K.-
item.contributorOkada, K.-
item.contributorTanaka, K.-
item.contributorLabori, K. J.-
item.contributorGoodsell, K. E.-
item.contributorAlberici, L.-
item.contributorWebber, L.-
item.contributorKirkov, L.-
item.contributorde Franco, L.-
item.contributorMiyashita, M.-
item.contributorMaglione, M.-
item.contributorGramellini, M.-
item.contributorRamera, M.-
item.contributorAmaral, M. J.-
item.contributorRamaekers, M.-
item.contributorTruty, M. J.-
item.contributorvan Dam, M. A.-
item.contributorStommel, M. W. J.-
item.contributorPetrikowski, M.-
item.contributorImamura, M.-
item.contributorHayashi, M.-
item.contributorD'Hondt, M.-
item.contributorBrunner, M.-
item.contributorHogg, M. E.-
item.contributorZhang, C.-
item.contributorSuarez-Munoz, M. A.-
item.contributorLuyer, M. D.-
item.contributorUnno, M.-
item.contributorMizuma, M.-
item.contributorJanot, M.-
item.contributorSahakyan, M. A.-
item.contributorJamieson, N. B.-
item.contributorBusch, O. R.-
item.contributorBilge, O.-
item.contributorBelyaev, O.-
item.contributorFranklin, O.-
item.contributorSanchez-Velazquez, P.-
item.contributorPessaux, P.-
item.contributorHolka, P. S.-
item.contributorGhorbani, P.-
item.contributorCasadei, R.-
item.contributorSartoris, R.-
item.contributorSchulick, R. D.-
item.contributorGrutzmann, R.-
item.contributorSutcliffe, R.-
item.contributorMata, R.-
item.contributorPatel, R. B.-
item.contributorTakahashi, R.-
item.contributorFranco, S. Rodriguez-
item.contributorCabus, S. S.-
item.contributorHirano, S.-
item.contributorGaujoux, S.-
item.contributorFesten, S.-
item.contributorKozono, S.-
item.contributorMaithel, S. K.-
item.contributorChai, S. M.-
item.contributorYamaki, S.-
item.contributorvan Laarhoven, S.-
item.contributorMieog, J. S. D.-
item.contributorMurakami, T.-
item.contributorCodjia, T.-
item.contributorSumiyoshi, T.-
item.contributorKarsten, T. M.-
item.contributorNakamura, T.-
item.contributorSugawara, T.-
item.contributorBoggi, U.-
item.contributorHartman, V.-
item.contributorde Meijer, V. E.-
item.contributorBartholoma, W.-
item.contributorKwon, W.-
item.contributorKoh, Y. X.-
item.contributorCho, Y.-
item.contributorTakeyama, Y.-
item.contributorInoue, Y.-
item.contributorNagakawa, Y.-
item.contributorKawamoto, Y.-
item.contributorOme, Y.-
item.contributorSoonawalla, Z.-
item.contributorUemura, K.-
item.contributorWolfgang, C. L.-
item.contributorJang, J. Y.-
item.contributorPadbury, R.-
item.contributorSatoi, S.-
item.contributorMessersmith, W.-
item.contributorWilmink, J. W.-
item.contributorAbu Hilal, M.-
item.contributorBesselink, M. G.-
item.contributorDel Chiaro, M.-
item.accessRightsOpen Access-
crisitem.journal.issn0923-7534-
crisitem.journal.eissn1569-8041-
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