Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/4639
Title: Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends
Authors: Ameye, D.
Pringels, E.
Foreman, P.
Remon, J.P.
ADRIAENSENS, Peter 
STORME, Liesbet 
GELAN, Jan 
Issue Date: 2005
Publisher: ELSEVIER
Source: Polymer, 46(7). p. 2338-2345
Abstract: Spray-dried Amioca® starch/Carbopol® 974P (C 974P; cross-linked poly(acrylic acid)) blends were evaluated as bioadhesive drug carriers and compared with equivalent physical mixtures. For both mixture types, the nano-morphology was determined by means of SEM and 13C-CP/MAS solid state NMR. Whereas phase separation occurs into individual starch and C 974P. This intimate mixing improves the bioadhesive capacity significantly as compared to equivalent physical mixtures. Up to 20 wt% content of C 974P, the spray-dried blends did not show any sign of irritation. This makes them promising biocompatible powders for application as safe bioadhesive carriers.
Document URI: http://hdl.handle.net/1942/4639
ISSN: 0032-3861
e-ISSN: 1873-2291
DOI: 10.1016/j.polymer.2005.01.026
ISI #: 000227654500036
Category: A1
Type: Journal Contribution
Validations: ecoom 2006
Appears in Collections:Research publications

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