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http://hdl.handle.net/1942/4639
Title: | Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends | Authors: | Ameye, D. Pringels, E. Foreman, P. Remon, J.P. ADRIAENSENS, Peter STORME, Liesbet GELAN, Jan |
Issue Date: | 2005 | Publisher: | ELSEVIER | Source: | Polymer, 46(7). p. 2338-2345 | Abstract: | Spray-dried Amioca® starch/Carbopol® 974P (C 974P; cross-linked poly(acrylic acid)) blends were evaluated as bioadhesive drug carriers and compared with equivalent physical mixtures. For both mixture types, the nano-morphology was determined by means of SEM and 13C-CP/MAS solid state NMR. Whereas phase separation occurs into individual starch and C 974P. This intimate mixing improves the bioadhesive capacity significantly as compared to equivalent physical mixtures. Up to 20 wt% content of C 974P, the spray-dried blends did not show any sign of irritation. This makes them promising biocompatible powders for application as safe bioadhesive carriers. | Document URI: | http://hdl.handle.net/1942/4639 | ISSN: | 0032-3861 | e-ISSN: | 1873-2291 | DOI: | 10.1016/j.polymer.2005.01.026 | ISI #: | 000227654500036 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2006 |
Appears in Collections: | Research publications |
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