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|Title:||Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends||Authors:||Ameye, D.
|Issue Date:||2005||Publisher:||ELSEVIER||Source:||Polymer, 46(7). p. 2338-2345||Abstract:||Spray-dried Amioca® starch/Carbopol® 974P (C 974P; cross-linked poly(acrylic acid)) blends were evaluated as bioadhesive drug carriers and compared with equivalent physical mixtures. For both mixture types, the nano-morphology was determined by means of SEM and 13C-CP/MAS solid state NMR. Whereas phase separation occurs into individual starch and C 974P. This intimate mixing improves the bioadhesive capacity significantly as compared to equivalent physical mixtures. Up to 20 wt% content of C 974P, the spray-dried blends did not show any sign of irritation. This makes them promising biocompatible powders for application as safe bioadhesive carriers.||Document URI:||http://hdl.handle.net/1942/4639||ISSN:||0032-3861||e-ISSN:||1873-2291||DOI:||10.1016/j.polymer.2005.01.026||ISI #:||000227654500036||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2006|
|Appears in Collections:||Research publications|
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