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http://hdl.handle.net/1942/4736
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DC Field | Value | Language |
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dc.contributor.author | Peeters, M. | - |
dc.contributor.author | Geypens, B. | - |
dc.contributor.author | Claus, D. | - |
dc.contributor.author | Nevens, H. | - |
dc.contributor.author | Ghoos, Y. | - |
dc.contributor.author | VERBEKE, Geert | - |
dc.contributor.author | Baert, F. | - |
dc.contributor.author | Vermeire, S. | - |
dc.contributor.author | Vlietinck, R. | - |
dc.contributor.author | Rutgeerts, P. | - |
dc.date.accessioned | 2007-12-20T15:52:10Z | - |
dc.date.available | 2007-12-20T15:52:10Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Gastroenterology, 113(3). p. 802-807 | - |
dc.identifier.uri | http://hdl.handle.net/1942/4736 | - |
dc.description.abstract | BACKGROUND & AIMS: Small intestinal permeability is increased in a proportion of patients with Crohn's disease (CD) and a subset of their healthy relatives. A primary permeability defect was postulated in the pathogenesis of the disease. The aim of this study was to identify a possible genetic pattern in the distribution of CD and/or abnormal permeability. METHODS: Differential urinary excretion of lactulose and mannitol (L/ M) in complete CD families was determined. Controls included healthy families and families with ulcerative colitis. Pedigrees were used to compare the distribution of CD and/or increased permeability. RESULTS: The L/M was significantly increased in patients with CD. Seventeen of 67 first-degree relatives (25%) had a ratio greater than the upper limit (P95 = 0.0170). Permeability results of CD families showed a highly significant familial aggregation. The lack of a genetic pattern in relation with CD and occurrence of disturbed permeability especially within generation, points toward a shared environmental factor. Five of 14 healthy spouses (36%) of patients with CD had also an increased permeability, and prevalence of increased permeability was not higher in families with known familial occurrence (P = 0.85). CONCLUSIONS: This large family study confirms an increased permeability in a subset of healthy relatives of patients with CD. However, the absence of a typical family pattern and the high prevalence in spouses is in favor of a common nongenetic factor or a subclinical disease manifestation. | - |
dc.language.iso | en | - |
dc.title | Clustering of increased small intestinal permeability in families with Crohn's disease | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 807 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 802 | - |
dc.identifier.volume | 113 | - |
dc.bibliographicCitation.oldjcat | - | |
dc.identifier.url | http://www.gastrojournal.org/article/S0016-5085(97)70174-4/abstract | - |
item.fullcitation | Peeters, M.; Geypens, B.; Claus, D.; Nevens, H.; Ghoos, Y.; VERBEKE, Geert; Baert, F.; Vermeire, S.; Vlietinck, R. & Rutgeerts, P. (1997) Clustering of increased small intestinal permeability in families with Crohn's disease. In: Gastroenterology, 113(3). p. 802-807. | - |
item.fulltext | No Fulltext | - |
item.contributor | Peeters, M. | - |
item.contributor | Geypens, B. | - |
item.contributor | Claus, D. | - |
item.contributor | Nevens, H. | - |
item.contributor | Ghoos, Y. | - |
item.contributor | VERBEKE, Geert | - |
item.contributor | Baert, F. | - |
item.contributor | Vermeire, S. | - |
item.contributor | Vlietinck, R. | - |
item.contributor | Rutgeerts, P. | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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