Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/48060
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dc.contributor.authorBAETEN, Paulien-
dc.contributor.authorBEETS, Karen-
dc.contributor.authorSCHALLEY, Tessa-
dc.contributor.authorVERREYCKEN, Janne-
dc.contributor.authorDURAN, Gayel-
dc.contributor.authorLINTSEN, Daphne-
dc.contributor.authorSCHUETZ, Lisa-
dc.contributor.authorZHONG, Xue-
dc.contributor.authorMOONEN, Brecht-
dc.contributor.authorBOGIE, Jeroen-
dc.contributor.authorVandenheuvel , Jeroen-
dc.contributor.authorVanderborght , Bart-
dc.contributor.authorVarela, Isma-
dc.contributor.authorKasmi, Sabah-
dc.contributor.authorSeynaeve, Elise-
dc.contributor.authorDe Coen, Ruben-
dc.contributor.authorDillen, Senne-
dc.contributor.authorAsci, Sinem Demirel-
dc.contributor.authorDe Vrieze, Jana-
dc.contributor.authorLambolez, Florence-
dc.contributor.authorHELLINGS, Niels-
dc.contributor.authorDe Koker, Stefaan-
dc.contributor.authorBROUX, Bieke-
dc.date.accessioned2026-01-12T12:19:46Z-
dc.date.available2026-01-12T12:19:46Z-
dc.date.issued2025-
dc.date.submitted2025-12-23T15:06:37Z-
dc.identifier.citationMultiple Sclerosis Journal, 31 (3) , p. 1342 -1343 (Art N° P411)-
dc.identifier.urihttp://hdl.handle.net/1942/48060-
dc.description.abstractIntroduction: Current treatments for autoimmunity are based on general immune suppression, while a true cure is still lacking. Therefore, efforts are being made to re-establish long-term tolerance in an antigen-specific manner. Objectives/Aims: We aim to develop a validated mRNA based tolerizing customized lipid nanoparticle (Tol-cLNP) vaccine to induce antigen-specific tolerance in MS and other autoimmune diseases. To achieve this, the antigen needs to be presented in an immune-silent manner. Methods: Tol-cLNP were loaded with myelin oligodendrocyte glycoprotein (MOG) mRNA and used for vaccination in different in vivo models. Results: Our data show that our MOG mRNA Tol-cLNP vaccine is indeed immune-silent, as shown by reduced interferon regulatory pathway activation in comparison to standard methods. Next,-
dc.description.sponsorshipVLAIO-
dc.language.isoen-
dc.publisherSAGE PUBLICATIONS LTD-
dc.rights2025 SAGE Publications-
dc.titleTherapeutic vaccination with auto-antigen mRNA loaded tolerizing lipid nanoparticles cures murine model of multiple sclerosis-
dc.typeJournal Contribution-
dc.identifier.epage1343-
dc.identifier.issue3-
dc.identifier.spage1342-
dc.identifier.volume31-
local.format.pages2-
local.bibliographicCitation.jcatM-
local.publisher.place1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedMeeting Abstract-
local.bibliographicCitation.artnrP411-
dc.identifier.isi001603659904212-
local.provider.typewosris-
local.description.affiliation[Baeten, Paulien; Schalley, Tessa; Verreycken, Janne; Duran, Gayel; Lintsen, Daphne; Schuetz, Lisa; Zhong, Xue; Moonen, Brecht; Bogie, Jeroen; Vandenheuvel, Jeroen; Hellings, Niels; Broux, Bieke] Hasselt Univ, Hasselt, Belgium.-
local.description.affiliation[Baeten, Paulien; Schalley, Tessa; Verreycken, Janne; Duran, Gayel; Lintsen, Daphne; Schuetz, Lisa; Zhong, Xue; Moonen, Brecht; Bogie, Jeroen; Hellings, Niels; Broux, Bieke] Univ MS Ctr, Hasselt, Belgium.-
local.description.affiliation[Beets, Karen; Vandenheuvel, Jeroen; Vanderborght, Bart; Varela, Isma; Kasmi, Sabah; Seynaeve, Elise; De Coen, Ruben; Dillen, Senne; Asci, Sinem Demirel; De Vrieze, Jana; Lambolez, Florence; De Koker, Stefaan] Etherna, Niel, Belgium.-
local.uhasselt.internationalno-
item.contributorBAETEN, Paulien-
item.contributorBEETS, Karen-
item.contributorSCHALLEY, Tessa-
item.contributorVERREYCKEN, Janne-
item.contributorDURAN, Gayel-
item.contributorLINTSEN, Daphne-
item.contributorSCHUETZ, Lisa-
item.contributorZHONG, Xue-
item.contributorMOONEN, Brecht-
item.contributorBOGIE, Jeroen-
item.contributorVandenheuvel , Jeroen-
item.contributorVanderborght , Bart-
item.contributorVarela, Isma-
item.contributorKasmi, Sabah-
item.contributorSeynaeve, Elise-
item.contributorDe Coen, Ruben-
item.contributorDillen, Senne-
item.contributorAsci, Sinem Demirel-
item.contributorDe Vrieze, Jana-
item.contributorLambolez, Florence-
item.contributorHELLINGS, Niels-
item.contributorDe Koker, Stefaan-
item.contributorBROUX, Bieke-
item.fulltextWith Fulltext-
item.fullcitationBAETEN, Paulien; BEETS, Karen; SCHALLEY, Tessa; VERREYCKEN, Janne; DURAN, Gayel; LINTSEN, Daphne; SCHUETZ, Lisa; ZHONG, Xue; MOONEN, Brecht; BOGIE, Jeroen; Vandenheuvel , Jeroen; Vanderborght , Bart; Varela, Isma; Kasmi, Sabah; Seynaeve, Elise; De Coen, Ruben; Dillen, Senne; Asci, Sinem Demirel; De Vrieze, Jana; Lambolez, Florence; HELLINGS, Niels; De Koker, Stefaan & BROUX, Bieke (2025) Therapeutic vaccination with auto-antigen mRNA loaded tolerizing lipid nanoparticles cures murine model of multiple sclerosis. In: Multiple Sclerosis Journal, 31 (3) , p. 1342 -1343 (Art N° P411).-
item.accessRightsRestricted Access-
crisitem.journal.issn1352-4585-
crisitem.journal.eissn1477-0970-
Appears in Collections:Research publications
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