Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/48347Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Albergoni, M. | - |
| dc.contributor.author | Rocca , M. | - |
| dc.contributor.author | Romano, F. | - |
| dc.contributor.author | Valsasina, P. | - |
| dc.contributor.author | Motl, R. | - |
| dc.contributor.author | Amato, M. | - |
| dc.contributor.author | Brichetto, G. | - |
| dc.contributor.author | Boccia, D. | - |
| dc.contributor.author | Chataway, J. | - |
| dc.contributor.author | Chiaravalloti, N. | - |
| dc.contributor.author | Cutter, G. | - |
| dc.contributor.author | Dalgas, U. | - |
| dc.contributor.author | Deluca, J. | - |
| dc.contributor.author | Farrell, R. | - |
| dc.contributor.author | FEYS, Peter | - |
| dc.contributor.author | Freeman, J. | - |
| dc.contributor.author | Inglese, M. | - |
| dc.contributor.author | Meza, C. | - |
| dc.contributor.author | Salter, A. | - |
| dc.contributor.author | Sandroff, B. | - |
| dc.contributor.author | Feinstein, A. | - |
| dc.contributor.author | Filippi, M. | - |
| dc.date.accessioned | 2026-02-02T11:58:02Z | - |
| dc.date.available | 2026-02-02T11:58:02Z | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2026-01-19T11:47:24Z | - |
| dc.identifier.citation | European Journal of Neurology, 32 (S1) (Art N° EPR-168) | - |
| dc.identifier.uri | http://hdl.handle.net/1942/48347 | - |
| dc.description.abstract | Background and aims: The anterior insula (AI) is crucial for cognitive attentional processes, while the posterior insula (PI) is related to somatosensory properties. CogEx trial (NCT03679468) investigated the effects of aerobic exercise (EX) and cognitive rehabilitation (CR) on cognitive impairment in progressive multiple sclerosis (MS). The aim of this study was to assess the effects of rehabilitation on resting state functional connectivity (RSFC) of AI and PI exploiting CogEx data. Methods: CogEx participants were randomized to: 'CR+EX', 'CR+sham EX (EX-S)', 'EX+sham CR (CR-S)' and 'CR-S+EX-S'. We selected all subjects (n = 87) who underwent the 12-week intervention period and completed baseline and 12-week physical/ cognitive and RS-fMRI assessments. RSFC of AI and PI was assessed using a seed-based approach. Results: At week-12 compared to baseline, groups performing CR were both characterized by increased RSFC between AI and the left temporal pole, while groups performing EX were both characterized by increased RSFC between AI and the left hippocampus. Conversely, 'CR-S+EX-S' patients were characterized by decreased RSFC of AI/PI with cingulate cortex and frontoparietal regions. In the 'EX+CR-S' group, increased RS FC | - |
| dc.description.sponsorship | MS Society of Canada [EGID3185]; CMSC; Danish MS Society; US MS Society | - |
| dc.language.iso | en | - |
| dc.publisher | WILEY | - |
| dc.rights | Aerobic and cognitive training effects on insular functional connectivity. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
| dc.title | Aerobic and cognitive training effects on insular functional connectivity in progressive multiple sclerosis: CogEx trial | - |
| dc.type | Journal Contribution | - |
| dc.identifier.issue | S1 | - |
| dc.identifier.volume | 32 | - |
| local.format.pages | 1 | - |
| local.bibliographicCitation.jcat | M | - |
| local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
| local.type.refereed | Refereed | - |
| local.type.specified | Meeting Abstract | - |
| local.bibliographicCitation.artnr | EPR-168 | - |
| dc.identifier.doi | 10.1111/ene.70191 | - |
| dc.identifier.isi | 001628319700835 | - |
| local.provider.type | wosris | - |
| local.description.affiliation | [Albergoni, M.; Romano, F.; Valsasina, P.] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy. | - |
| local.description.affiliation | [Rocca, M.] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy. | - |
| local.description.affiliation | [Rocca, M.] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy. | - |
| local.description.affiliation | [Rocca, M.; Filippi, M.] Univ Vita Salute San Raffaele, Milan, Italy. | - |
| local.description.affiliation | [Motl, R.] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL USA. | - |
| local.description.affiliation | [Amato, M.] Univ Florence, Dept NEUROFARBA, Sect Neurosci, Florence, Italy. | - |
| local.description.affiliation | [Amato, M.] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy. | - |
| local.description.affiliation | [Brichetto, G.] Italian Multiple Sclerosis Fdn FISM, Sci Res Area, Genoa, Italy. | - |
| local.description.affiliation | [Boccia, D.; Inglese, M.] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy. | - |
| local.description.affiliation | [Boccia, D.; Inglese, M.] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy. | - |
| local.description.affiliation | [Chataway, J.; Farrell, R.] UCL, Queen Sq Inst Neurol, Queen Sq Multiple Sclerosis Ctr, Dept Neuroinflammat, London, England. | - |
| local.description.affiliation | [Chiaravalloti, N.; Deluca, J.; Sandroff, B.] Kessler Fdn, W Orange, NJ USA. | - |
| local.description.affiliation | [Cutter, G.] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA. | - |
| local.description.affiliation | [Dalgas, U.] Aarhus Univ, Dept Publ Hlth, Exercise Biol, Aarhus, Denmark. | - |
| local.description.affiliation | [Feys, P.] Hasselt Univ, Fac Rehabil Sci, REVAL, Diepenbeek, Belgium. | - |
| local.description.affiliation | [Freeman, J.] Univ Plymouth, Fac Hlth, Sch Hlth Profess, Plymouth, Devon, England. | - |
| local.description.affiliation | [Meza, C.; Feinstein, A.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada. | - |
| local.description.affiliation | [Meza, C.; Feinstein, A.] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. | - |
| local.description.affiliation | [Salter, A.] UT Southwestern Med Ctr, Dept Neurol, Sect Stat Planning & Anal, Dallas, TX USA. | - |
| local.description.affiliation | [Filippi, M.] IRCCS San Raffaele Sci Inst, Div Neurosci, Neurol Unit, Neuroimaging Res Unit,Neurorehabil Unit,Neurophysi, Milan, Italy. | - |
| local.uhasselt.international | yes | - |
| item.fullcitation | Albergoni, M.; Rocca , M.; Romano, F.; Valsasina, P.; Motl, R.; Amato, M.; Brichetto, G.; Boccia, D.; Chataway, J.; Chiaravalloti, N.; Cutter, G.; Dalgas, U.; Deluca, J.; Farrell, R.; FEYS, Peter; Freeman, J.; Inglese, M.; Meza, C.; Salter, A.; Sandroff, B.; Feinstein, A. & Filippi, M. (2025) Aerobic and cognitive training effects on insular functional connectivity in progressive multiple sclerosis: CogEx trial. In: European Journal of Neurology, 32 (S1) (Art N° EPR-168). | - |
| item.contributor | Albergoni, M. | - |
| item.contributor | Rocca , M. | - |
| item.contributor | Romano, F. | - |
| item.contributor | Valsasina, P. | - |
| item.contributor | Motl, R. | - |
| item.contributor | Amato, M. | - |
| item.contributor | Brichetto, G. | - |
| item.contributor | Boccia, D. | - |
| item.contributor | Chataway, J. | - |
| item.contributor | Chiaravalloti, N. | - |
| item.contributor | Cutter, G. | - |
| item.contributor | Dalgas, U. | - |
| item.contributor | Deluca, J. | - |
| item.contributor | Farrell, R. | - |
| item.contributor | FEYS, Peter | - |
| item.contributor | Freeman, J. | - |
| item.contributor | Inglese, M. | - |
| item.contributor | Meza, C. | - |
| item.contributor | Salter, A. | - |
| item.contributor | Sandroff, B. | - |
| item.contributor | Feinstein, A. | - |
| item.contributor | Filippi, M. | - |
| item.fulltext | With Fulltext | - |
| item.accessRights | Open Access | - |
| crisitem.journal.issn | 1351-5101 | - |
| crisitem.journal.eissn | 1468-1331 | - |
| Appears in Collections: | Research publications | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Euro J of Neurology .pdf | Published version | 86.19 kB | Adobe PDF | View/Open |
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