Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/48685
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dc.contributor.authorHuang, Qi-Fang-
dc.contributor.authorAn, De-Wei-
dc.contributor.authorAparicio, Lucas S.-
dc.contributor.authorCheng, Yi-Bang-
dc.contributor.authorWei, Fang-Fei-
dc.contributor.authorBoggia, José-
dc.contributor.authorYang, Wen-Yi-
dc.contributor.authorSheng, Chang-Sheng-
dc.contributor.authorMARTENS, Dries-
dc.contributor.authorStolarz-Skrzypek, Katarzyna-
dc.contributor.authorWojciechowska, Wiktoria-
dc.contributor.authorRajzer, Marek-
dc.contributor.authorTikhonoff, Valérie-
dc.contributor.authorCasiglia, Edoardo-
dc.contributor.authorGilis-Malinowska, Natasza-
dc.contributor.authorNarkiewicz, Krzysztof-
dc.contributor.authorSeidlerová, Jitka-
dc.contributor.authorFilipovský, Jan-
dc.contributor.authorKawecka-Jaszcz, Kalina-
dc.contributor.authorWang, Ji-Guang-
dc.contributor.authorAparicio, L. S.-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorLi, Yan-
dc.contributor.authorStaessen, Jan A.-
dc.contributor.authorWei, D. M.-
dc.contributor.authorThijs, L.-
dc.contributor.authorWei, F. F.-
dc.contributor.authorYang, W. Y.-
dc.contributor.authorZhang, Z. Y.-
dc.contributor.authorCheng, Y. B.-
dc.contributor.authorGuo, Q. H.-
dc.contributor.authorHuang, J. F.-
dc.contributor.authorHuang, Q. F.-
dc.contributor.authorSheng, C. S.-
dc.contributor.authorWang, J. G.-
dc.contributor.authorFilipovsky, J.-
dc.contributor.authorAn, D. W.-
dc.contributor.authorSeidlerova, J.-
dc.contributor.authorJuhanoja, E. P.-
dc.contributor.authorJula, A. M.-
dc.contributor.authorLindroos, A. S.-
dc.contributor.authorNiiranen, T. J.-
dc.contributor.authorSiven, S. S.-
dc.contributor.authorCasiglia, E.-
dc.contributor.authorPizzioli, A.-
dc.contributor.authorTikhonoff, V.-
dc.contributor.authorChori, B. S.-
dc.contributor.authorDanladi, B.-
dc.contributor.authorOdili, A. N.-
dc.contributor.authorOshaju, H.-
dc.contributor.authorKucharska, W.-
dc.contributor.authorKunicka, K.-
dc.contributor.authorGilis-Malinowska, N.-
dc.contributor.authorNarkiewicz, K.-
dc.contributor.authorSakiewicz, W.-
dc.contributor.authorSwierblewska, E.-
dc.contributor.authorKawecka-Jaszcz, K.-
dc.contributor.authorStolarz-Skrzypek, K.-
dc.contributor.authorRajzer, M.-
dc.contributor.authorMels, C.-
dc.contributor.authorKruger, R.-
dc.contributor.authorMokwatsi, G.-
dc.contributor.authorSchutte, A. E.-
dc.contributor.authorNorton, G. R.-
dc.contributor.authorWoodiwiss, A. J.-
dc.contributor.authorAckermann, D.-
dc.contributor.authorBochud, M.-
dc.contributor.authorEhret, G.-
dc.contributor.authorAlvarez-Vaz, R.-
dc.contributor.authorAmerico, C.-
dc.contributor.authorBaccino, C.-
dc.contributor.authorBorgarello, L.-
dc.contributor.authorFlorio, L.-
dc.contributor.authorMoliterno, P.-
dc.contributor.authorNoboa, A.-
dc.contributor.authorNoboa, O.-
dc.contributor.authorOlascoaga, A.-
dc.contributor.authorParnizari, P.-
dc.contributor.authorPecora, M.-
dc.date.accessioned2026-03-05T10:20:03Z-
dc.date.available2026-03-05T10:20:03Z-
dc.date.issued2026-
dc.date.submitted2026-03-04T08:00:13Z-
dc.identifier.citationHypertension research,-
dc.identifier.urihttp://hdl.handle.net/1942/48685-
dc.description.abstractMultiple articles focused on the central arterial systolic (SPTI) and diastolic (DPTI) pressure-time indexes and the subendocardial viability ratio (SEVR). However,whether these indexes contribute to risk stratification in the general populationisunknown.SPTI,DPTIandSEVRwerenoninvasivelymeasuredbytheSphygmoCor technology. Incidence ratesandstandardized(per1-SDincrement)multivariable-adjustedhazardratios (HRs) for cardiovascular (primary) and cardiac endpoints and stroke were evaluated in the International Database of Central Arterial Properties for Risk Stratification (n=5099). Model refinement was assessed by the area under the curve (AUC) and the integrated discrimination(IDI)andnet reclassification(NRI) improvement.Over4years (median),215cardiovascular,133cardiac endpointsand79strokesoccurred.ForSPTI,fullyadjustedHRswere1.37(95%CI:1.18-1.59),1.35(1.11-1.64)and1.33 (1.05-1.69)forthecardiovascularandcardiacendpointsandstroke.ThecorrespondingHRsforDPTIwere1.49(1.31-1.69), 1.23 (1.02-1.48) and1.74 (1.46-2.07). ForSEVR, noneof theHRs reachedsignificance.Analyseswith these indexes categorizedbyquartileswereconfirmatory.Analysesstratifiedbyvariousriskfactorsdidnot revealsubgroupdifferences. For thecardiovascularendpoint,addingSPTIorDPTI tothebasemodel improvedtheAUC,whileaddingSPTIorDPTI combinedwithmeanarterialpressure,increasedIDIby~1.7%andNRIby~17%(P<0.001forall).Whereascardiovascular andcardiacendpointsandstrokewererelatedwiththenon-invasivelymeasuredSPTIandDPTI,SEVRwasnot.-
dc.description.sponsorshipArgentina: The Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Belgium: European Union (HEALTH-F7-305507 HOMAGE), European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-ofConcept Grant 713601-uPROPHET), European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT) and Research Foundation Flanders, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13); China: The National Natural Science Foundation of China (grants 82270469, 82070432, 81970353), the Ministry of Science and Technology (2022YFC3601302), Beijing, China, and by the Shanghai Commissions of Science and Technology (grants 19ZR1443300), the Shanghai Municipal Health Commission (202340035, 20234Y0036, 201940297 and a Grant for Leading Academics 2022LJ022), and the Shanghai Talent Work Bureau (the Oriental Talent Program BJWS2024086 and QNWS2024013); Czech Republic: European Union (grants LSHM-CT-2006–037093 and HEALTH-F4-2007–201550) and Charles University Research program “Cooperatio– Cardiovascular Science”; Italy: European Union (grants LSHM-CT-2006–037093 and HEALTH-F4-2007–201550); Poland (Gdańsk): European Union (grants LSHM-CT-2006–037093 and HEALTH-F4-2007–201550); Poland (Kraków): European Union (grants LSHM-CT-2006–037093 and HEALTH-F4-2007–201550) and Foundation for Polish Science; Uruguay: Asociación Española Primera en Salud. The funding source had no role had in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Acknowledgements The Non-Profit Research Alliance for the Promotion of Preventive Medicine (URL: www.appremed.org) received a non-binding grant from OMRON Healthcare Co., Ltd., Kyoto, Japan. The Guangci Laureate Professorship of Jan A. Staessen is supported by the Guangci Deep Mind Project of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.-
dc.language.isoen-
dc.publisherSpringer-
dc.rightsTheAuthor(s),underexclusivelicencetoTheJapaneseSocietyofHypertension2026-
dc.subject.otherCentralarterialpressuretimeindexes-
dc.subject.othercardiovasculardisease-
dc.subject.otherdigitalhypertension-
dc.subject.otherpopulationscience-
dc.subject.otherrisk stratification-
dc.titleCardiovascular endpoints in relation to the central arterial pressure-time indexes-
dc.typeJournal Contribution-
local.bibliographicCitation.jcatA1-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.statusEarly view-
dc.identifier.doi10.1038/s41440-026-02555-2-
local.provider.typeCrossRef-
local.uhasselt.internationalyes-
item.accessRightsClosed Access-
item.fulltextWith Fulltext-
item.contributorHuang, Qi-Fang-
item.contributorAn, De-Wei-
item.contributorAparicio, Lucas S.-
item.contributorCheng, Yi-Bang-
item.contributorWei, Fang-Fei-
item.contributorBoggia, José-
item.contributorYang, Wen-Yi-
item.contributorSheng, Chang-Sheng-
item.contributorMARTENS, Dries-
item.contributorStolarz-Skrzypek, Katarzyna-
item.contributorWojciechowska, Wiktoria-
item.contributorRajzer, Marek-
item.contributorTikhonoff, Valérie-
item.contributorCasiglia, Edoardo-
item.contributorGilis-Malinowska, Natasza-
item.contributorNarkiewicz, Krzysztof-
item.contributorSeidlerová, Jitka-
item.contributorFilipovský, Jan-
item.contributorKawecka-Jaszcz, Kalina-
item.contributorWang, Ji-Guang-
item.contributorAparicio, L. S.-
item.contributorNAWROT, Tim-
item.contributorLi, Yan-
item.contributorStaessen, Jan A.-
item.contributorWei, D. M.-
item.contributorThijs, L.-
item.contributorWei, F. F.-
item.contributorYang, W. Y.-
item.contributorZhang, Z. Y.-
item.contributorCheng, Y. B.-
item.contributorGuo, Q. H.-
item.contributorHuang, J. F.-
item.contributorHuang, Q. F.-
item.contributorSheng, C. S.-
item.contributorWang, J. G.-
item.contributorFilipovsky, J.-
item.contributorAn, D. W.-
item.contributorSeidlerova, J.-
item.contributorJuhanoja, E. P.-
item.contributorJula, A. M.-
item.contributorLindroos, A. S.-
item.contributorNiiranen, T. J.-
item.contributorSiven, S. S.-
item.contributorCasiglia, E.-
item.contributorPizzioli, A.-
item.contributorTikhonoff, V.-
item.contributorChori, B. S.-
item.contributorDanladi, B.-
item.contributorOdili, A. N.-
item.contributorOshaju, H.-
item.contributorKucharska, W.-
item.contributorKunicka, K.-
item.contributorGilis-Malinowska, N.-
item.contributorNarkiewicz, K.-
item.contributorSakiewicz, W.-
item.contributorSwierblewska, E.-
item.contributorKawecka-Jaszcz, K.-
item.contributorStolarz-Skrzypek, K.-
item.contributorRajzer, M.-
item.contributorMels, C.-
item.contributorKruger, R.-
item.contributorMokwatsi, G.-
item.contributorSchutte, A. E.-
item.contributorNorton, G. R.-
item.contributorWoodiwiss, A. J.-
item.contributorAckermann, D.-
item.contributorBochud, M.-
item.contributorEhret, G.-
item.contributorAlvarez-Vaz, R.-
item.contributorAmerico, C.-
item.contributorBaccino, C.-
item.contributorBorgarello, L.-
item.contributorFlorio, L.-
item.contributorMoliterno, P.-
item.contributorNoboa, A.-
item.contributorNoboa, O.-
item.contributorOlascoaga, A.-
item.contributorParnizari, P.-
item.contributorPecora, M.-
item.fullcitationHuang, Qi-Fang; An, De-Wei; Aparicio, Lucas S.; Cheng, Yi-Bang; Wei, Fang-Fei; Boggia, José; Yang, Wen-Yi; Sheng, Chang-Sheng; MARTENS, Dries; Stolarz-Skrzypek, Katarzyna; Wojciechowska, Wiktoria; Rajzer, Marek; Tikhonoff, Valérie; Casiglia, Edoardo; Gilis-Malinowska, Natasza; Narkiewicz, Krzysztof; Seidlerová, Jitka; Filipovský, Jan; Kawecka-Jaszcz, Kalina; Wang, Ji-Guang; Aparicio, L. S.; NAWROT, Tim; Li, Yan; Staessen, Jan A.; Wei, D. M.; Thijs, L.; Wei, F. F.; Yang, W. Y.; Zhang, Z. Y.; Cheng, Y. B.; Guo, Q. H.; Huang, J. F.; Huang, Q. F.; Sheng, C. S.; Wang, J. G.; Filipovsky, J.; An, D. W.; Seidlerova, J.; Juhanoja, E. P.; Jula, A. M.; Lindroos, A. S.; Niiranen, T. J.; Siven, S. S.; Casiglia, E.; Pizzioli, A.; Tikhonoff, V.; Chori, B. S.; Danladi, B.; Odili, A. N.; Oshaju, H.; Kucharska, W.; Kunicka, K.; Gilis-Malinowska, N.; Narkiewicz, K.; Sakiewicz, W.; Swierblewska, E.; Kawecka-Jaszcz, K.; Stolarz-Skrzypek, K.; Rajzer, M.; Mels, C.; Kruger, R.; Mokwatsi, G.; Schutte, A. E.; Norton, G. R.; Woodiwiss, A. J.; Ackermann, D.; Bochud, M.; Ehret, G.; Alvarez-Vaz, R.; Americo, C.; Baccino, C.; Borgarello, L.; Florio, L.; Moliterno, P.; Noboa, A.; Noboa, O.; Olascoaga, A.; Parnizari, P. & Pecora, M. (2026) Cardiovascular endpoints in relation to the central arterial pressure-time indexes. In: Hypertension research,.-
crisitem.journal.issn0916-9636-
crisitem.journal.eissn1348-4214-
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