Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/48731
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dc.contributor.authorSandhu, Geeta-
dc.contributor.authorAdattini, Josephine-
dc.contributor.authorGordon, Evangeline Armstrong-
dc.contributor.authorO'neill, Niamh-
dc.contributor.authorBagnis, Corrine-
dc.contributor.authorChambers, Pinkie-
dc.contributor.authorMartin, Jennifer H.-
dc.contributor.authorFlynn, Alex-
dc.contributor.authorIbrahim, Karim-
dc.contributor.authorJardine, Meg J.-
dc.contributor.authorJohnson, David W.-
dc.contributor.authorJones, Graham R. D.-
dc.contributor.authorKarapetis, Christos S.-
dc.contributor.authorKelly, Aisling-
dc.contributor.authorKichenadasse, Ganessan-
dc.contributor.authorKliman, David S.-
dc.contributor.authorLiauw, Winston-
dc.contributor.authorLucas, Catherine-
dc.contributor.authorMallett, Andrew J.-
dc.contributor.authorMalyszko, Jolanta-
dc.contributor.authorMichael, Michael-
dc.contributor.authorPollock, Carol A.-
dc.contributor.authorRoberts, Darren M.-
dc.contributor.authorRosner, Mitchell H.-
dc.contributor.authorRoutledge, David J. M.-
dc.contributor.authorScuderi, Carla-
dc.contributor.authorShingleton, Julia-
dc.contributor.authorShortt, Jake-
dc.contributor.authorSiderov, Jim-
dc.contributor.authorSPRANGERS, Ben-
dc.contributor.authorStein, Brian N.-
dc.contributor.authorTunnicliffe, David J.-
dc.contributor.authorWebber, Kate-
dc.contributor.authorWard, Robyn L.-
dc.date.accessioned2026-03-12T14:17:59Z-
dc.date.available2026-03-12T14:17:59Z-
dc.date.issued2025-
dc.date.submitted2026-03-09T16:17:41Z-
dc.identifier.citationEClinicalMedicine, 82 (Art N° 103102)-
dc.identifier.urihttp://hdl.handle.net/1942/48731-
dc.description.abstractThe kidney disease: Improving Global Outcomes (KDIGO) guideline recommends assessing kidney function using glomerular filtration rate (GFR) either through direct measurement or through estimation (eGFR) and describes a standardised classification of reduced kidney function. KDIGO guidelines have been adopted by most internal medicine specialities for the assessment and classification of kidney function, but not by cancer medicine. The development of the International Consensus Guideline on Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) aims to overcome the perceived challenges with KDIGO recommendations by describing their utility in patients with cancer. Two virtual, consensus building workshops were held consecutively, involving international, multidisciplinary participants (Part 1 of ADDIKD development). During these workshops, three consensus recommendations were agreed upon based on KDIGO's principles; to standardise kidney function assessment, classify kidney function, and determine a uniform approach to dose anticancer drugs in patients with reduced kidney mendations. These issues were addressed by nephrologists, clinical pharmacologists, and other clinicians with extensive experience in the contemporary assessment of kidney function. The key concern for cancer specialists was a hesitancy to move away from the familiar and long-standing practice of using the Cockcroft-Gault equation to estimate creatinine clearance. The consensus building within the two multidisciplinary workshops allowed a thorough assessment of the evidence and clarified how directly measured GFR and eGFR, rather than creatinine clearance, could be optimally utilised in cancer care. The development of Part 1 of the ADDIKD guideline represents a standardised, contemporary approach to the assessment, classification, and utility of kidney function in the setting of cancer care and it harmonises with the approach used in other areas of medicine internationally.-
dc.description.sponsorshipFunding Development of the ADDIKD guideline is funded by the Cancer Institute NSW as part of the NSW Government and received no funding from external commercial sources.-
dc.language.isoen-
dc.publisherELSEVIER-
dc.rights2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).-
dc.subject.otherChemotherapy-
dc.subject.otherDrug dosing-
dc.subject.otherKidney dysfunction-
dc.subject.otherRenal-
dc.subject.otherOncology-
dc.subject.otherHaematology-
dc.subject.otherPharmacokinetics-
dc.titleAligning kidney function assessment in patients with cancer to global practices in internal medicine-
dc.typeJournal Contribution-
dc.identifier.volume82-
local.format.pages11-
local.bibliographicCitation.jcatA1-
dc.description.notesSandhu, G (corresponding author), Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.; Sandhu, G (corresponding author), Canc Inst NSW, EviQ, St Leonards, NSW, Australia.; Sandhu, G (corresponding author), St Vincents Hosp, Pharm Dept, Sydney, NSW, Australia.-
dc.description.notesgeetpal.sandhu@svha.org.au-
local.publisher.placeRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS-
local.type.refereedRefereed-
local.type.specifiedReview-
local.bibliographicCitation.artnr103102-
dc.identifier.doi10.1016/j.eclinm.2025.103102-
dc.identifier.pmid40290845-
dc.identifier.isi001700957000001-
local.provider.typewosris-
local.description.affiliation[Sandhu, Geeta; Pollock, Carol A.; Ward, Robyn L.] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.-
local.description.affiliation[Sandhu, Geeta; Adattini, Josephine; Gordon, Evangeline Armstrong; O'neill, Niamh; Kelly, Aisling; Shingleton, Julia; Ward, Robyn L.] Canc Inst NSW, EviQ, St Leonards, NSW, Australia.-
local.description.affiliation[Sandhu, Geeta] St Vincents Hosp, Pharm Dept, Sydney, NSW, Australia.-
local.description.affiliation[Bagnis, Corrine] Sorbonne Univ, APHP, Nephrol Dept, Paris, France.-
local.description.affiliation[Chambers, Pinkie] UCL, Sch Pharm, London, England.-
local.description.affiliation[Chambers, Pinkie] UCL, Univ Coll London Hosp, Ctr Med Optimisat Res & Educ, London, England.-
local.description.affiliation[Martin, Jennifer H.; Flynn, Alex; Lucas, Catherine] Univ Newcastle, Ctr Drug Repurposing, Newcastle, NSW, Australia.-
local.description.affiliation[Ibrahim, Karim; Jones, Graham R. D.] Univ New South Wales, Fac Med & Hlth, Sydney, NSW, Australia.-
local.description.affiliation[Jardine, Meg J.] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW, Australia.-
local.description.affiliation[Jardine, Meg J.] Concord Repatriat Gen Hosp, Concord, NSW, Australia.-
local.description.affiliation[Johnson, David W.] Univ Queensland, Australasian Kidney Trials Network, Brisbane, Qld, Australia.-
local.description.affiliation[Johnson, David W.] Princess Alexandra Hosp, Dept Kidney & Transplant Serv, Brisbane, Qld, Australia.-
local.description.affiliation[Johnson, David W.] Translat Res Inst, Brisbane, Qld, Australia.-
local.description.affiliation[Jones, Graham R. D.] St Vincents Hosp, Dept Chem Pathol, SydPath, Sydney, NSW, Australia.-
local.description.affiliation[Karapetis, Christos S.; Kichenadasse, Ganessan] Flinders Univ S Australia, Flinders Ctr Innovat Canc, Flinders Med Ctr, Bedford Pk, SA, Australia.-
local.description.affiliation[Kliman, David S.] Royal North Shore Hosp, Dept Haematol, Sydney, NSW, Australia.-
local.description.affiliation[Liauw, Winston] St George Hosp, Canc Care Ctr, Kogarah, NSW, Australia.-
local.description.affiliation[Liauw, Winston] Univ New South Wales, Sch Clin Med, Sydney, NSW, Australia.-
local.description.affiliation[Mallett, Andrew J.] Townsville Univ Hosp, Dept Renal Med, Townsville, Qld, Australia.-
local.description.affiliation[Mallett, Andrew J.] James Cook Univ, Coll Med & Dent, Townsville, Qld, Australia.-
local.description.affiliation[Mallett, Andrew J.] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.-
local.description.affiliation[Malyszko, Jolanta] Warsaw Med Univ, Dept Nephrol Dialysis & Internal Med, Warsaw, Poland.-
local.description.affiliation[Michael, Michael; Routledge, David J. M.] Peter MacCallum Canc Ctr, Parkville, Vic, Australia.-
local.description.affiliation[Michael, Michael] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.-
local.description.affiliation[Pollock, Carol A.] Kolling Inst Med Res, Sydney, NSW, Australia.-
local.description.affiliation[Roberts, Darren M.] Royal Prince Alfred Hosp, Edith Collins Ctr, Drug Hlth Serv, Camperdown, NSW, Australia.-
local.description.affiliation[Rosner, Mitchell H.] Univ Virginia Hlth, Dept Med, Charlottesville, VA USA.-
local.description.affiliation[Routledge, David J. M.] Royal Melbourne Hosp, Clin Haematol, Parkville, Vic, Australia.-
local.description.affiliation[Scuderi, Carla] Royal Brisbane & Womens Hosp, Pharm Dept, Brisbane, Qld, Australia.-
local.description.affiliation[Scuderi, Carla] Univ Queensland, Sch Pharm, Brisbane, Qld, Australia.-
local.description.affiliation[Shortt, Jake] Monash Hlth, Monash Haematol, Clayton, Vic, Australia.-
local.description.affiliation[Shortt, Jake; Webber, Kate] Monash Univ, Monash Hlth, Sch Clin Sci, Dept Med, Clayton, Vic, Australia.-
local.description.affiliation[Siderov, Jim] Austin Hlth, Pharm Dept, Melbourne, Vic, Australia.-
local.description.affiliation[Sprangers, Ben] UHasselt, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium.-
local.description.affiliation[Sprangers, Ben] Ziekenhuis Oost Limburg, Dept Nephrol, Genk, Belgium.-
local.description.affiliation[Stein, Brian N.] Icon Canc Ctr, Adelaide, SA, Australia.-
local.description.affiliation[Stein, Brian N.] Univ Adelaide, Adelaide, SA, Australia.-
local.description.affiliation[Tunnicliffe, David J.] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia.-
local.description.affiliation[Tunnicliffe, David J.] Childrens Hosp Westmead, Ctr Kidney Res, Westmead, NSW, Australia.-
local.description.affiliation[Webber, Kate] Monash Hlth, Dept Med Oncol, Clayton, Vic, Australia.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.contributorSandhu, Geeta-
item.contributorAdattini, Josephine-
item.contributorGordon, Evangeline Armstrong-
item.contributorO'neill, Niamh-
item.contributorBagnis, Corrine-
item.contributorChambers, Pinkie-
item.contributorMartin, Jennifer H.-
item.contributorFlynn, Alex-
item.contributorIbrahim, Karim-
item.contributorJardine, Meg J.-
item.contributorJohnson, David W.-
item.contributorJones, Graham R. D.-
item.contributorKarapetis, Christos S.-
item.contributorKelly, Aisling-
item.contributorKichenadasse, Ganessan-
item.contributorKliman, David S.-
item.contributorLiauw, Winston-
item.contributorLucas, Catherine-
item.contributorMallett, Andrew J.-
item.contributorMalyszko, Jolanta-
item.contributorMichael, Michael-
item.contributorPollock, Carol A.-
item.contributorRoberts, Darren M.-
item.contributorRosner, Mitchell H.-
item.contributorRoutledge, David J. M.-
item.contributorScuderi, Carla-
item.contributorShingleton, Julia-
item.contributorShortt, Jake-
item.contributorSiderov, Jim-
item.contributorSPRANGERS, Ben-
item.contributorStein, Brian N.-
item.contributorTunnicliffe, David J.-
item.contributorWebber, Kate-
item.contributorWard, Robyn L.-
item.fullcitationSandhu, Geeta; Adattini, Josephine; Gordon, Evangeline Armstrong; O'neill, Niamh; Bagnis, Corrine; Chambers, Pinkie; Martin, Jennifer H.; Flynn, Alex; Ibrahim, Karim; Jardine, Meg J.; Johnson, David W.; Jones, Graham R. D.; Karapetis, Christos S.; Kelly, Aisling; Kichenadasse, Ganessan; Kliman, David S.; Liauw, Winston; Lucas, Catherine; Mallett, Andrew J.; Malyszko, Jolanta; Michael, Michael; Pollock, Carol A.; Roberts, Darren M.; Rosner, Mitchell H.; Routledge, David J. M.; Scuderi, Carla; Shingleton, Julia; Shortt, Jake; Siderov, Jim; SPRANGERS, Ben; Stein, Brian N.; Tunnicliffe, David J.; Webber, Kate & Ward, Robyn L. (2025) Aligning kidney function assessment in patients with cancer to global practices in internal medicine. In: EClinicalMedicine, 82 (Art N° 103102).-
item.accessRightsOpen Access-
crisitem.journal.eissn2589-5370-
Appears in Collections:Research publications
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