Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/48832
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dc.contributor.authorSerruys, Patrick W.-
dc.contributor.authorTsai, Tsung-Ying-
dc.contributor.authorWykrzykowska, Joanna J.-
dc.contributor.authorSharif, Faisal-
dc.contributor.authorRosseel, Liesbeth-
dc.contributor.authorAlkhalil, Mohammad-
dc.contributor.authorCurzen, Nick-
dc.contributor.authorFlore, Vincent-
dc.contributor.authorBENIT, Edouard-
dc.contributor.authorPankert, Mathieu-
dc.contributor.authorBATAILLE, Yoann-
dc.contributor.authorvon Birgelen, Clemens-
dc.contributor.authorDe Wilder, Kenneth-
dc.contributor.authorParadies, Valeria-
dc.contributor.authorAmoroso, Giovanni-
dc.contributor.authorMangin, Lionel-
dc.contributor.authorSabate, Manel-
dc.contributor.authorSomi, Samer-
dc.contributor.authorAminian, Adel-
dc.contributor.authorHofma, Sjoerd-
dc.contributor.authorSantos, Ignacio J. Amat-
dc.contributor.authorDiaz, Victor Alfonso Jimenez-
dc.contributor.authorBarone-Rochette, Gilles-
dc.contributor.authorMathur, Anthony-
dc.contributor.authorSonck, Jeroen-
dc.contributor.authorAdjedj, Julien-
dc.contributor.authorMonsegu, Jacques-
dc.contributor.authorLemoine, Julien-
dc.contributor.authorAngioi, Michael-
dc.contributor.authorJuanatey, Carlos Gonzalez-
dc.contributor.authorZabalawi, Amer-
dc.contributor.authorKanehama, Nozomu-
dc.contributor.authorTobe, Akihiro-
dc.contributor.authorMiyashita, Kotaro-
dc.contributor.authorBednarek, Adrian-
dc.contributor.authorOshima, Asahi-
dc.contributor.authorChinhenzva, Albert-
dc.contributor.authorWadhwa, Kanika-
dc.contributor.authorGarg, Scot-
dc.contributor.authorBaumbach, Andreas-
dc.contributor.authorSmits, Peter-
dc.contributor.authorOnuma, Yoshinobu-
dc.date.accessioned2026-04-02T12:31:48Z-
dc.date.available2026-04-02T12:31:48Z-
dc.date.issued2026-
dc.date.submitted2026-03-31T12:49:35Z-
dc.identifier.citationEuropean heart journal,-
dc.identifier.urihttp://hdl.handle.net/1942/48832-
dc.description.sponsorshipFunding This study was sponsored by the University of Galway with a research grant from Sino Medical Sciences Technology Inc. Acknowledgement The PIONEER IV trial was sponsored by the University of Galway. We thank the members of the DSMB (Prof. Pedro Lemos, Prof. Dominick Angiolillo, and Dr. Alberto Alvarez-Iglesias) and the Clinical Events Committee (Prof. Scot Garg, Dr. Maik Grundeken, and Dr. Javaid Iqbal) for their contributions to ensuring the safe conduct of the trial and adjudication of events. We are grateful to Medis Medical Imaging for technical support to the sites and the central core laboratory. We also deeply appreciate the intellectual contributions of our visiting scholars, Dr. Gonçalo Costa and Dr. Jacopo Farina, and the guidance of our steering committee members, Prof. William Wijns and Prof. Andrew Smith. Finally, we thank the PIONEER IV coordination, data management, and trial safety teams for their dedication, and we are indebted to the participating patients and investigators.-
dc.language.isoen-
dc.publisherOXFORD UNIV PRESS-
dc.rightsThe Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.subject.otherQuantitative flow ratio guidance-
dc.subject.otherUsual care guidance-
dc.subject.otherNon-inferiority trial-
dc.subject.otherAll comers percutaneous coronary intervention-
dc.subject.otherHealing-Targeted Supreme sirolimus-eluting stent-
dc.subject.otherTicagrelor monotherapy-
dc.titleAngiography-derived fractional flow reserve- vs usual care-guided percutaneous coronary intervention: interim analysis of the PIONEER IV trial-
dc.typeJournal Contribution-
local.format.pages5-
local.bibliographicCitation.jcatA1-
dc.description.notesSerruys, PW (corresponding author), Univ Galway, CORRIB Res Ctr Adv Imaging & Core Lab, Univ Rd, Galway H91 TK33, Ireland.-
dc.description.notespatrick.w.j.c.serruys@gmail.com-
local.publisher.placeGREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.statusEarly view-
dc.identifier.doi10.1093/eurheartj/ehag174-
dc.identifier.pmid41841754-
dc.identifier.isi001716452400001-
dc.contributor.orcidSerruys, Patrick W/0000-0002-9636-1104;-
local.provider.typewosris-
local.description.affiliation[Serruys, Patrick W.; Tsai, Tsung-Ying; Kanehama, Nozomu; Tobe, Akihiro; Miyashita, Kotaro; Bednarek, Adrian; Oshima, Asahi; Chinhenzva, Albert; Wadhwa, Kanika; Onuma, Yoshinobu] Univ Galway, CORRIB Res Ctr Adv Imaging & Core Lab, Univ Rd, Galway H91 TK33, Ireland.-
local.description.affiliation[Wykrzykowska, Joanna J.] Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.-
local.description.affiliation[Sharif, Faisal] Univ Galway, Dept Cardiol, Galway, Ireland.-
local.description.affiliation[Sharif, Faisal] Univ Galway, SFI Infrastruct Funding, Galway, Ireland.-
local.description.affiliation[Rosseel, Liesbeth] Algemeen Stedelijk Ziekenhuis, Dept Cardiol, Aalst, Belgium.-
local.description.affiliation[Alkhalil, Mohammad] Freeman Rd Hosp, Cardiothorac Ctr, Newcastle Upon Tyne, England.-
local.description.affiliation[Alkhalil, Mohammad] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, England.-
local.description.affiliation[Curzen, Nick] Univ Southampton, Fac Med, Southampton, England.-
local.description.affiliation[Curzen, Nick] Univ Hosp Southampton NHS Trust, Dept Cardiol, Southampton, England.-
local.description.affiliation[Flore, Vincent] AZ Maria Middelares, Dept Cardiol, Ghent, Belgium.-
local.description.affiliation[Benit, Edouard; Bataille, Yoann] Jessa Hosp, Dept Cardiol, Hasselt, Belgium.-
local.description.affiliation[Pankert, Mathieu] Ctr Hosp Avignon, Serv Cardiol, Avignon, France.-
local.description.affiliation[von Birgelen, Clemens] Med Spectrum Twente, Dept Cardiol, Thoraxcentrum Twente, Enschede, Netherlands.-
local.description.affiliation[von Birgelen, Clemens] Univ Twente, Fac Behav Management & Social Sci, Tech Med Ctr, Hlth Technol & Serv Res, Enschede, Netherlands.-
local.description.affiliation[De Wilder, Kenneth] Imelda Hosp Bonheiden, Heart Ctr, Bonheiden, Belgium.-
local.description.affiliation[Paradies, Valeria] Maasstad Hosp, Dept Cardiol, Rotterdam, Netherlands.-
local.description.affiliation[Amoroso, Giovanni] OLVG, Dept Cardiol, Amsterdam, Netherlands.-
local.description.affiliation[Mangin, Lionel] Hosp Annecy Genevois, Cardiol Dept, Metz Tessy, France.-
local.description.affiliation[Sabate, Manel] IDIBAPS, Univ Hosp Clin, Cardiovasc Inst, Intervent Cardiol Dept, Barcelona, Spain.-
local.description.affiliation[Sabate, Manel; Santos, Ignacio J. Amat] Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Intervent Cardiol Dept, Madrid, Spain.-
local.description.affiliation[Somi, Samer] Haga Hosp, Dept Cardiol, The Hague, Netherlands.-
local.description.affiliation[Aminian, Adel] CHU Charleroi, Div Cardiol, Charleroi, Belgium.-
local.description.affiliation[Hofma, Sjoerd] FrisiusMC, Dept Cardiol, Leeuwarden, Netherlands.-
local.description.affiliation[Santos, Ignacio J. Amat] Univ Clin Hosp Valladolid, Cardiol Dept, Valladoild, Spain.-
local.description.affiliation[Santos, Ignacio J. Amat] Inst Invest Biosanit Valladolid IBioVALL, Cardiovasc Res Area, Valladolid, Spain.-
local.description.affiliation[Diaz, Victor Alfonso Jimenez] Univ Hosp Vigo, Hosp Alvaro Cunqueiro, Cardiol Dept, Vigo, Pontevedra, Spain.-
local.description.affiliation[Diaz, Victor Alfonso Jimenez] SERGAS UVIGO, Cardiovasc Res Grp, Galicia Sur Hlth Res Inst IIS Galicia Sur, Vigo, Spain.-
local.description.affiliation[Barone-Rochette, Gilles] Univ Hosp Grenoble, Dept Cardiol, Grenoble, France.-
local.description.affiliation[Barone-Rochette, Gilles] Univ Grenoble Alpes, Cardiovasc & Thorac Dept, Clin Cardiol, INSERM,CHU Grenoble Alpes, Grenoble, France.-
local.description.affiliation[Barone-Rochette, Gilles] French Clin Res Infrastruct Network, French Alliance Clin Trial, Paris, France.-
local.description.affiliation[Mathur, Anthony] Barts Hlth NHS Trust, Barts Heart Ctr, London, England.-
local.description.affiliation[Mathur, Anthony] Queen Mary Univ London, William Harvey Res Inst, Ctr Cardiovasc Med & Devices, London, England.-
local.description.affiliation[Mathur, Anthony] Queen Mary Univ London, NIHR Barts Biomed Res Ctr, Charterhouse Sq, London, England.-
local.description.affiliation[Sonck, Jeroen] AZorg Hosp, Cardiovasc Ctr Aalst, Aalst, Belgium.-
local.description.affiliation[Adjedj, Julien] Arnault Tzanck Inst, Cardiol Dept, St Laurent Du Var, France.-
local.description.affiliation[Monsegu, Jacques] Medipole Private Hosp, GCV Cardiopole, Grenoble, France.-
local.description.affiliation[Lemoine, Julien; Angioi, Michael] Clin Louis Pasteur, Dept Cardiol, Esseys Les Nancy, France.-
local.description.affiliation[Juanatey, Carlos Gonzalez] Lucus Augusti Univ Hosp, Cardiol Dept, CardioHULA Res Grp, Lugo, Spain.-
local.description.affiliation[Zabalawi, Amer] Ctr Hosp St Brieuc, Dept Cardiol, 10 Rue Marcel Proust, F-22000 St Brieuc, France.-
local.description.affiliation[Bednarek, Adrian] Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland.-
local.description.affiliation[Garg, Scot] Royal Blackburn Hosp, Dept Cardiol, Blackburn, England.-
local.description.affiliation[Garg, Scot] Univ Lancashire, Sch Med, Preston, England.-
local.description.affiliation[Baumbach, Andreas; Smits, Peter] Queen Mary Univ London, William Harvey Res Inst, Ctr Cardiovasc Med & Devices, London, England.-
local.description.affiliation[Baumbach, Andreas] Barts Hlth NHS Trust, Barts Heart Ctr, Dept Cardiol, London, England.-
local.description.affiliation[Smits, Peter] Maasstad Ziekenhuis, Dept Cardiol, Rotterdam, Netherlands.-
local.uhasselt.internationalyes-
item.fullcitationSerruys, Patrick W.; Tsai, Tsung-Ying; Wykrzykowska, Joanna J.; Sharif, Faisal; Rosseel, Liesbeth; Alkhalil, Mohammad; Curzen, Nick; Flore, Vincent; BENIT, Edouard; Pankert, Mathieu; BATAILLE, Yoann; von Birgelen, Clemens; De Wilder, Kenneth; Paradies, Valeria; Amoroso, Giovanni; Mangin, Lionel; Sabate, Manel; Somi, Samer; Aminian, Adel; Hofma, Sjoerd; Santos, Ignacio J. Amat; Diaz, Victor Alfonso Jimenez; Barone-Rochette, Gilles; Mathur, Anthony; Sonck, Jeroen; Adjedj, Julien; Monsegu, Jacques; Lemoine, Julien; Angioi, Michael; Juanatey, Carlos Gonzalez; Zabalawi, Amer; Kanehama, Nozomu; Tobe, Akihiro; Miyashita, Kotaro; Bednarek, Adrian; Oshima, Asahi; Chinhenzva, Albert; Wadhwa, Kanika; Garg, Scot; Baumbach, Andreas; Smits, Peter & Onuma, Yoshinobu (2026) Angiography-derived fractional flow reserve- vs usual care-guided percutaneous coronary intervention: interim analysis of the PIONEER IV trial. In: European heart journal,.-
item.fulltextWith Fulltext-
item.contributorSerruys, Patrick W.-
item.contributorTsai, Tsung-Ying-
item.contributorWykrzykowska, Joanna J.-
item.contributorSharif, Faisal-
item.contributorRosseel, Liesbeth-
item.contributorAlkhalil, Mohammad-
item.contributorCurzen, Nick-
item.contributorFlore, Vincent-
item.contributorBENIT, Edouard-
item.contributorPankert, Mathieu-
item.contributorBATAILLE, Yoann-
item.contributorvon Birgelen, Clemens-
item.contributorDe Wilder, Kenneth-
item.contributorParadies, Valeria-
item.contributorAmoroso, Giovanni-
item.contributorMangin, Lionel-
item.contributorSabate, Manel-
item.contributorSomi, Samer-
item.contributorAminian, Adel-
item.contributorHofma, Sjoerd-
item.contributorSantos, Ignacio J. Amat-
item.contributorDiaz, Victor Alfonso Jimenez-
item.contributorBarone-Rochette, Gilles-
item.contributorMathur, Anthony-
item.contributorSonck, Jeroen-
item.contributorAdjedj, Julien-
item.contributorMonsegu, Jacques-
item.contributorLemoine, Julien-
item.contributorAngioi, Michael-
item.contributorJuanatey, Carlos Gonzalez-
item.contributorZabalawi, Amer-
item.contributorKanehama, Nozomu-
item.contributorTobe, Akihiro-
item.contributorMiyashita, Kotaro-
item.contributorBednarek, Adrian-
item.contributorOshima, Asahi-
item.contributorChinhenzva, Albert-
item.contributorWadhwa, Kanika-
item.contributorGarg, Scot-
item.contributorBaumbach, Andreas-
item.contributorSmits, Peter-
item.contributorOnuma, Yoshinobu-
item.accessRightsOpen Access-
crisitem.journal.issn0195-668X-
crisitem.journal.eissn1522-9645-
Appears in Collections:Research publications
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