Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/49058
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dc.contributor.authorHoang , Thanh T.-
dc.contributor.authorCosin-Tomas, Marta-
dc.contributor.authorLee, Yunsung-
dc.contributor.authorMonasso, Giulietta-
dc.contributor.authorXu, Zongli-
dc.contributor.authorLi, Sebastian Shaobo-
dc.contributor.authorZeng, Xuehuo-
dc.contributor.authorStarling, Anne P.-
dc.contributor.authorREIMANN, Brigitte-
dc.contributor.authorRoder, Stefan-
dc.contributor.authorZillich, Lea-
dc.contributor.authorJima, Dereje D.-
dc.contributor.authorThio, Chris H. L.-
dc.contributor.authorPesce, Giancarlo-
dc.contributor.authorKersten, Elin T. G.-
dc.contributor.authorBreeze, Charles E.-
dc.contributor.authorBurkholder, Adam B.-
dc.contributor.authorLee, Mikyeong-
dc.contributor.authorWard, James M.-
dc.contributor.authorALFANO, Rossella-
dc.contributor.authorDeuschle, Michael-
dc.contributor.authorDuijts, Liesbeth-
dc.contributor.authorGhassabian, Akhgar-
dc.contributor.authorGOMEZ HERRERA, Laura-
dc.contributor.authorJaddoe, Vincent W. V.-
dc.contributor.authorMotsinger-Reif, Alison A.-
dc.contributor.authorLie, Rolv T.-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorPage, Christian M.-
dc.contributor.authorSend, Tabea S.-
dc.contributor.authorSharp, Gemma-
dc.contributor.authorStein, Dan J.-
dc.contributor.authorStreit, Fabian-
dc.contributor.authorSunyer, Jordi-
dc.contributor.authorWilcox, Allen J.-
dc.contributor.authorZar, Heather J.-
dc.contributor.authorKoppelman, Gerard H.-
dc.contributor.authorAnnesi-Maesano, Isabella-
dc.contributor.authorCorpeleijn, Eva-
dc.contributor.authorSnieder, Harold-
dc.contributor.authorHoyo, Cathrine-
dc.contributor.authorHuls, Anke-
dc.contributor.authorSirignano, Lea-
dc.contributor.authorWitt, Stephanie H.-
dc.contributor.authorHerberth, Gunda-
dc.contributor.authorPLUSQUIN, Michelle-
dc.contributor.authorDabelea, Dana-
dc.contributor.authorYeung, Edwina-
dc.contributor.authorWiemels, Joseph L.-
dc.contributor.authorRichmond, Rebecca C.-
dc.contributor.authorTaylor, Jack A.-
dc.contributor.authorFelix, Janine F.-
dc.contributor.authorHaberg, Siri E.-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorLondon, Stephanie J.-
dc.date.accessioned2026-05-12T09:51:15Z-
dc.date.available2026-05-12T09:51:15Z-
dc.date.issued2026-
dc.date.submitted2026-05-12T09:41:16Z-
dc.identifier.citationEnvironmental health perspectives,-
dc.identifier.urihttp://hdl.handle.net/1942/49058-
dc.description.abstractBACKGROUND: Maternal sustained smoking during pregnancy is associated with thousands of differentially methylated CpGs in newborns, but impacts of other prenatal tobacco smoking exposures remain unclear. OBJECTIVE: To identify differential DNA methylation in newborns from maternal sustained smoking and less studied prenatal smoking exposures (i.e., maternal exposure to secondhand smoke [SHS] exposure during pregnancy, maternal quitting before pregnancy, paternal smoking around conception, and paternal quitting before pregnancy). METHODS: We conducted a large meta-analysis of prenatal tobacco smoking exposures and epigenome-wide newborn blood DNA methylation through the Pregnancy And Childhood Epigenetics Consortium (PACE). Across 19 cohorts, 11,175 parent-newborn pairs contributed information on at least one prenatal smoking exposure, mostly from questionnaires. Maternal blood or urine cotinine measurements, available in a few studies, provided objective data for maternal SHS and smoking during pregnancy. Primary analyses used Illumina450 K methylation data; secondary analyses in 5 cohorts examined CpGs unique to the EPIC array. RESULTS: Maternal sustained smoking associated with differential DNA methylation (false discovery rate [FDR] < 0.05) at 8,862 CpGs on the 450 K (n = 8,148) and did not differ by infant sex. We identified over 300 novel genes not previously identified in EWAS of smoking. No differential methylation was associated with maternal SHS, maternal former smoking, or paternal smoking around conception. However, cg24805739 (MED13L) was associated with former paternal former smoking. Forty-one novel genes were identified using maternal cotinine measurements compared to questionnaire. In EPIC unique analyses (n = 3,415), differential methylation was observed with maternal sustained smoking (211 CpGs), maternal SHS (5 CpGs), and paternal former smoking (4 CpGs). Smoking-associated CpGs in blood were strongly enriched for functional elements across multiple tissues. CONCLUSIONS: Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking, and paternal smoking.-
dc.description.sponsorshipG.H.K. received grants or contracts from ZonMw, Vertex, Netherlands Lung Foundation, GSK, Teva The Netherlands, and European Union (outside the submitted work). This work was funded by the Intramural Research Program of National Institutes of Health (National Institute of Environmental Health Sciences ZO1 ES49019). The European Union’s Horizon 2020 research and innovation programme-EU.3.1.2. (874583 - ATHLETE project), and the Beatriu de Pinós Postdoctoral Contract awarded by Generalitat-de-CatalunyaAGAUR and EU-H2020 (2019-BP-00107) to M.C.T. We acknowledge support from the grant CEX2023-0001290-S funded by MCIN/AEI/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program. Funding for individual authors and cohorts are listed in the Supplemental Methods. No funder/sponsor were involved in this study.-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.rightsThe Authors. Published by American Chemical Society. This article is licensed under CC-BY-NC-ND 4.0.-
dc.titlePrenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood-
dc.typeJournal Contribution-
local.format.pages14-
local.bibliographicCitation.jcatA1-
dc.description.notesLondon, SJ (corresponding author), NIEHS, Div Intramural Res, NIH, Res Triangle Pk, NC 27709 USA.-
dc.description.noteslondon2@niehs.nih.gov-
local.publisher.place1155 16TH ST, NW, WASHINGTON, DC 20036 USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.statusEarly view-
local.type.programmeH2020-
local.relation.h2020EU.3.1.2. (874583) - ATHLETE + 2019-BP-00107-
dc.identifier.doi10.1021/EHP.6c00142-
dc.identifier.isi001742544500001-
local.provider.typewosris-
local.description.affiliation[Hoang, Thanh T.; Lee, Mikyeong; London, Stephanie J.] NIEHS, Div Intramural Res, NIH, Res Triangle Pk, NC 27709 USA.-
local.description.affiliation[Hoang, Thanh T.] Baylor Coll Med, Dept Pediat, Div Hematol Oncol, Houston, TX 77030 USA.-
local.description.affiliation[Hoang, Thanh T.] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA.-
local.description.affiliation[Hoang, Thanh T.] Texas Childrens Hosp, Canc & Hematol Ctr, Houston, TX 77030 USA.-
local.description.affiliation[Cosin-Tomas, Marta; Herrera, Laura-Concepcio Gomez; Sunyer, Jordi; Bustamante, Mariona] Barcelona Inst Global Hlth, ISGlobal, Barcelona 08036, Spain.-
local.description.affiliation[Cosin-Tomas, Marta; Sunyer, Jordi; Bustamante, Mariona] Univ Pompeu Fabra, Barcelona 08005, Spain.-
local.description.affiliation[Cosin-Tomas, Marta; Sunyer, Jordi; Bustamante, Mariona] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid 28029, Spain.-
local.description.affiliation[Lee, Yunsung; Lie, Rolv T.; Haberg, Siri E.] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, N-0213 Oslo, Norway.-
local.description.affiliation[Monasso, Giulietta; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Generat R Study Grp, Erasmus MC, POB 2040, NL-3000 CA Rotterdam, Netherlands.-
local.description.affiliation[Monasso, Giulietta; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, POB 2040, NL-3000 CA Rotterdam, Netherlands.-
local.description.affiliation[Xu, Zongli; Motsinger-Reif, Alison A.] NIEHS, Biostat & Computat Biol Branch, Res Triangle Pk, NC 27709 USA.-
local.description.affiliation[Li, Sebastian Shaobo; Wiemels, Joseph L.] Univ Southern Calif, Ctr Genet Epidemiol, Dept Populat & Publ Hlth Sci, Los Angeles, CA 90089 USA.-
local.description.affiliation[Zeng, Xuehuo] Glotech Inc, Rockville, MD 20850 USA.-
local.description.affiliation[Starling, Anne P.; Dabelea, Dana] Univ Colorado, Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Anschutz Med Campus, Aurora, CO 80045 USA.-
local.description.affiliation[Starling, Anne P.] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.-
local.description.affiliation[Reimann, Brigitte; Alfano, Rossella; Herrera, Laura-Concepcio Gomez; Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci CMK, B-3590 Diepenbeek, Belgium.-
local.description.affiliation[Roder, Stefan; Herberth, Gunda] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, D-04318 Leipzig, Germany.-
local.description.affiliation[Zillich, Lea; Streit, Fabian; Sirignano, Lea; Witt, Stephanie H.] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, D-68135 Mannheim, Germany.-
local.description.affiliation[Jima, Dereje D.; Hoyo, Cathrine] North Carolina State Univ, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA.-
local.description.affiliation[Jima, Dereje D.; Hoyo, Cathrine] North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27607 USA.-
local.description.affiliation[Thio, Chris H. L.; Corpeleijn, Eva; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 GZ Groningen, Netherlands.-
local.description.affiliation[Pesce, Giancarlo] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ IPLESP, Fac Med St Antoine, Epidemiol Allerg & Resp Dis EPAR Team, Paris, France.-
local.description.affiliation[Pesce, Giancarlo] INSERM, UMR S 1136, Paris, France.-
local.description.affiliation[Pesce, Giancarlo] Certara Italy, I-20124 Milan, Italy.-
local.description.affiliation[Kersten, Elin T. G.; Koppelman, Gerard H.] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, NL-9713 GZ Groningen, Netherlands.-
local.description.affiliation[Kersten, Elin T. G.; Koppelman, Gerard H.] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, NL-9713 RB Groningen, Netherlands.-
local.description.affiliation[Breeze, Charles E.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.-
local.description.affiliation[Burkholder, Adam B.] NIEHS, Off Environm Sci Cyberinfrastruct, NIH, Res Triangle Pk, NC 27709 USA.-
local.description.affiliation[Ward, James M.] NIEHS, Integrat Bioinformat, NIH, Res Triangle Pk, NC 27709 USA.-
local.description.affiliation[Deuschle, Michael; Send, Tabea S.; Streit, Fabian] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Mannheim, Germany.-
local.description.affiliation[Duijts, Liesbeth] Univ Med Ctr Rotterdam, Dept Pediat, Div Resp Med & Allergol, Erasmus MC, NL-3015 GD Rotterdam, Netherlands.-
local.description.affiliation[Duijts, Liesbeth] Univ Med Ctr Rotterdam, Erasmus MC, Dept Neonatal & Pediat Intens Care, Div Neonatol, NL-3015 GD Rotterdam, Netherlands.-
local.description.affiliation[Ghassabian, Akhgar] NYU, Dept Pediat, Grossman Sch Med, New York, NY 10016 USA.-
local.description.affiliation[Ghassabian, Akhgar] NYU, Dept Populat Hlth, Grossman Sch Med, New York, NY 10016 USA.-
local.description.affiliation[Herrera, Laura-Concepcio Gomez] Univ Barcelona, Barcelona 08007, Spain.-
local.description.affiliation[Lie, Rolv T.] Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway.-
local.description.affiliation[Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, B-3500 Hasselt, Belgium.-
local.description.affiliation[Nawrot, Tim S.] Leuven Univ, Hlth & Environm Unit, B-3000 Leuven, Belgium.-
local.description.affiliation[Page, Christian M.] Norwegian Inst Publ Hlth, Dept Phys Hlth & Ageing, Div Publ Hlth & Prevent, N-0213 Oslo, Norway.-
local.description.affiliation[Sharp, Gemma] Univ Exeter, Sch Psychol, Exeter EX4 4QG, England.-
local.description.affiliation[Stein, Dan J.] Univ Cape Town, Neurosci Inst, Fac Hlth Sci, Dept Psychiat, ZA-7701 Cape Town, South Africa.-
local.description.affiliation[Stein, Dan J.] South African Med Res Council, Unit Risk & Resilience Mental Disorders, ZA-7505 Cape Town, South Africa.-
local.description.affiliation[Streit, Fabian; Witt, Stephanie H.] German Ctr Mental Hlth DZPG, Partner Site Mannheim Heidelberg Ulm, D-68195 Mannheim, Germany.-
local.description.affiliation[Streit, Fabian; Taylor, Jack A.] Heidelberg Univ, Hector Inst Artificial Intelligence Psychiat, Cent Inst Mental Hlth, Med Fac Mannheim, D-68135 Mannheim, Germany.-
local.description.affiliation[Sunyer, Jordi] IMIM Hosp del Mar, Med Res Inst, Barcelona 08003, Spain.-
local.description.affiliation[Wilcox, Allen J.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.-
local.description.affiliation[Zar, Heather J.] Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, ZA-7700 Cape Town, South Africa.-
local.description.affiliation[Zar, Heather J.] South African Med Res Council SAMRC, Unit Child & Adolescent Hlth, ZA-7700 Cape Town, South Africa.-
local.description.affiliation[Annesi-Maesano, Isabella] Inst Desbrest Epidemiol & Publ Hlth, UMR1318, INSERM, F-34295 Montpellier, France.-
local.description.affiliation[Annesi-Maesano, Isabella] Univ Montpellier, F-34295 Montpellier, France.-
local.description.affiliation[Annesi-Maesano, Isabella] Univ Hosp Montpellier, Dept Pulmonol Allergy & Thorac Oncol, F-34295 Montpellier, France.-
local.description.affiliation[Hoyo, Cathrine] North Carolina State Univ, Toxicol Program, Raleigh, NC 27695 USA.-
local.description.affiliation[Hoyo, Cathrine] North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA.-
local.description.affiliation[Huls, Anke] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.-
local.description.affiliation[Huls, Anke] Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, GA 30322 USA.-
local.description.affiliation[Huls, Anke] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.-
local.description.affiliation[Witt, Stephanie H.] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Ctr Innovat Psychiat & Psychotherapy Res ZIPP, D-68167 Mannheim, Germany.-
local.description.affiliation[Yeung, Edwina] Eunice Kennedy Shriver NICHHD, Div Populat Hlth Res, Div Intramural Res, Epidemiol Branch, Bethesda, MD 20892 USA.-
local.description.affiliation[Richmond, Rebecca C.] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, England.-
local.description.affiliation[Richmond, Rebecca C.] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol BS8 2BN, England.-
local.uhasselt.internationalyes-
item.fullcitationHoang , Thanh T.; Cosin-Tomas, Marta; Lee, Yunsung; Monasso, Giulietta; Xu, Zongli; Li, Sebastian Shaobo; Zeng, Xuehuo; Starling, Anne P.; REIMANN, Brigitte; Roder, Stefan; Zillich, Lea; Jima, Dereje D.; Thio, Chris H. L.; Pesce, Giancarlo; Kersten, Elin T. G.; Breeze, Charles E.; Burkholder, Adam B.; Lee, Mikyeong; Ward, James M.; ALFANO, Rossella; Deuschle, Michael; Duijts, Liesbeth; Ghassabian, Akhgar; GOMEZ HERRERA, Laura; Jaddoe, Vincent W. V.; Motsinger-Reif, Alison A.; Lie, Rolv T.; NAWROT, Tim; Page, Christian M.; Send, Tabea S.; Sharp, Gemma; Stein, Dan J.; Streit, Fabian; Sunyer, Jordi; Wilcox, Allen J.; Zar, Heather J.; Koppelman, Gerard H.; Annesi-Maesano, Isabella; Corpeleijn, Eva; Snieder, Harold; Hoyo, Cathrine; Huls, Anke; Sirignano, Lea; Witt, Stephanie H.; Herberth, Gunda; PLUSQUIN, Michelle; Dabelea, Dana; Yeung, Edwina; Wiemels, Joseph L.; Richmond, Rebecca C.; Taylor, Jack A.; Felix, Janine F.; Haberg, Siri E.; Bustamante, Mariona & London, Stephanie J. (2026) Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood. In: Environmental health perspectives,.-
item.fulltextWith Fulltext-
item.contributorHoang , Thanh T.-
item.contributorCosin-Tomas, Marta-
item.contributorLee, Yunsung-
item.contributorMonasso, Giulietta-
item.contributorXu, Zongli-
item.contributorLi, Sebastian Shaobo-
item.contributorZeng, Xuehuo-
item.contributorStarling, Anne P.-
item.contributorREIMANN, Brigitte-
item.contributorRoder, Stefan-
item.contributorZillich, Lea-
item.contributorJima, Dereje D.-
item.contributorThio, Chris H. L.-
item.contributorPesce, Giancarlo-
item.contributorKersten, Elin T. G.-
item.contributorBreeze, Charles E.-
item.contributorBurkholder, Adam B.-
item.contributorLee, Mikyeong-
item.contributorWard, James M.-
item.contributorALFANO, Rossella-
item.contributorDeuschle, Michael-
item.contributorDuijts, Liesbeth-
item.contributorGhassabian, Akhgar-
item.contributorGOMEZ HERRERA, Laura-
item.contributorJaddoe, Vincent W. V.-
item.contributorMotsinger-Reif, Alison A.-
item.contributorLie, Rolv T.-
item.contributorNAWROT, Tim-
item.contributorPage, Christian M.-
item.contributorSend, Tabea S.-
item.contributorSharp, Gemma-
item.contributorStein, Dan J.-
item.contributorStreit, Fabian-
item.contributorSunyer, Jordi-
item.contributorWilcox, Allen J.-
item.contributorZar, Heather J.-
item.contributorKoppelman, Gerard H.-
item.contributorAnnesi-Maesano, Isabella-
item.contributorCorpeleijn, Eva-
item.contributorSnieder, Harold-
item.contributorHoyo, Cathrine-
item.contributorHuls, Anke-
item.contributorSirignano, Lea-
item.contributorWitt, Stephanie H.-
item.contributorHerberth, Gunda-
item.contributorPLUSQUIN, Michelle-
item.contributorDabelea, Dana-
item.contributorYeung, Edwina-
item.contributorWiemels, Joseph L.-
item.contributorRichmond, Rebecca C.-
item.contributorTaylor, Jack A.-
item.contributorFelix, Janine F.-
item.contributorHaberg, Siri E.-
item.contributorBustamante, Mariona-
item.contributorLondon, Stephanie J.-
item.accessRightsOpen Access-
crisitem.journal.issn0091-6765-
crisitem.journal.eissn1552-9924-
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