Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/49190| Title: | Identification of transcription factors driving fibroblast differentiation towards an inflammatory phenotype by single-nucleus multiomics | Authors: | Fu, Y. Tubeeckx, M. Virzi, A. EKHTERAEITOUSI, Samaneh Troffaes, J. Thienpont, B. De Keulenaer, G. HEIDBUCHEL, Hein Segers, V Roderick, L. |
Issue Date: | 2026 | Publisher: | OXFORD UNIV PRESS | Source: | Cardiovascular research, 122 (Supplement_1) , p. il30 -il31 (Art N° cvag092105) | Abstract: | Introduction: Atrial fibrillation (AF) is highly prevalent in the aged population, contributing to ischemic stroke and HF development. Atrial myopathy (AM), characterized by electrical and structural remodeling, including atrial enlargement, provides the substrate for AF. AM is associated with changes in cell type composition, interactions, and phenotypes. These changes in the atria and the transition to AF require reprogramming in cell transcriptomes mediated by interactions between transcription factors (TFs), cis-regulatory elements (CRE) and the epigenome. The role of this regulome in AM and the evolution to AF is yet to be established. | Document URI: | http://hdl.handle.net/1942/49190 | ISSN: | 0008-6363 | e-ISSN: | 1755-3245 | DOI: | 10.1093/cvr/cvag092.105 | ISI #: | 001765698500033 | Category: | M | Type: | Journal Contribution |
| Appears in Collections: | Research publications |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| cvag092.105.pdf | Published version | 251.12 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.