Tailored NiCo conductive MOF on laser-induced graphene electrode toward enhanced glucose sensing performance

Abstract

There is a critical need to develop high-performance, easy-to-use glucose (Glu) sensors to support effective diabetes care and monitoring. Featuring high catalytic properties, improved electroconductibility, tunable porosity, and large surface area, conductive metal-organic frameworks (cMOF) (e.g., HHTP-based cMOF) have emerged as attractive platforms for boosting the performance of electrochemical Glu sensors. Laser-induced graphene (LIG) on a polyimide (PI) substrate has attracted considerable research interest in electrochemical sensor, stemming from its excellent conductive properties, flexibility and straightforward fabrication process. Herein, LIG electrode was integrated with NiCo-HHTP, forming a novel NiCo-HHTP/LIG sensor toward Glu. Under optimal conditions, the prepared NiCo-HHTP/LIG sensor demonstrates a low detection limit of 0.12 mu M. The superior electrocatalytic performance of the NiCo-HHTP/LIG sensor is attributed to the bimetallic synergies of NiCo-HHTP and porous structure of LIG, which provides numerous exposed active sites, a high surface area and extraordinary electroconductibility. The sensor's suitability for real-sample analysis was confirmed by successful Glu detection in honey and human sweat, with recoveries calculated to be between 93.8% and 105.2%. This work introduces a viable electrode option to advance the field of non-enzymatic Glu sensing, particularly for applications requiring in-situ and on-site analysis.