Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/49871
Title: Family system disruptions, probable depression and stress levels among caregivers of children aged 0-17 years in Uganda: evidence from baseline data of a cluster randomized controlled trial
Authors: Kamacooko, Onesmus
NSUBUGA, Rebecca 
Byekwaso, Carol N.
Okot, Betty
Ikwara, Emmanuel Asher
Melendez-Torres, G. J.
Lachman, Jamie M.
Godfrey, Siu
Issue Date: 2026
Publisher: BMC
Source: BMC psychiatry, 26 (1) (Art N° 593)
Abstract: Background Probable depression and stress significantly burden Ugandan caregivers, with prevalence rates up to 30%. Stress triggers harsh discipline, while depression leads to neglect. Guided by Family Systems Theory (FST), this study used Parenting for Respectability (PfR) programme data to examine how family system disruptions especially past exposure to violence, household size and partner status affect caregiver mental health outcomes to inform context-specific parenting interventions. Methods Baseline data from 2,314 caregivers in the PfR cRCT (2021-2022) were analysed. Data on demographics, probable depression and Stress were collected using structured questionnaires. Mixed-effects regression models, adjusting for clustering, examined the associations between family system disruptions and probable depression and stress using STATA 16.0. Results Among 2,314 caregivers, 53.4% were female, with a mean age of 37.9 +/- 11.9 years. Nearly half reported depressive symptoms (47.4%, 95% CI: 45.3%-49.4%), and the mean parental stress score was 36.5 +/- 15.9. Family system disruptions were significant predictors of poor mental health: past exposure to violence showed a strong, consistent association with both depression (beta range: 0.28-0.36) and stress (beta range: 0.38-0.49). We report adjusted beta coefficients beta (95% CI). Regarding household structure, being a single mother 1.48 (0.21, 2.71), residing in a large household 1.53 (0.86, 2.20), and caregiver disability 1.58 (0.11, 3.05) were significantly linked to increased symptoms. Conversely, having a partner was strongly protective against both probable depression - 4.41 (- 5.87, - 2.96) and stress - 2.87 (- 4.01, - 1.73). Compared with caregivers aged 18-30, those aged 31-40 and 41-50 had higher probable depression: 1.96 (0.95-2.97), 2.59 (1.44-3.73), and stress: 2.28 (1.50-3.07), 2.98 (2.10-3.87) respectively. Those > 50 reported highest stress: 3.55 (2.58-4.52). Female caregivers had higher depression and stress, while social support and equitable gender norms reduced distress. Conclusion Family system disruptions influence caregiver mental health. Stress and depressive symptoms were higher among caregivers aged 31-50 compared to those aged 18-30. Targeted interventions should focus on violence-exposed, middle-aged, and female caregivers by strengthening social support and providing skills to identify and manage early mental health symptoms.
Notes: Kamacooko, O (corresponding author), Makerere Univ, Coll Hlth Sci, Child Hlth & Dev Ctr, Kampala, Uganda.
kamaones1@gmail.com
Keywords: Probable depression;Stress;DASS-21;Parenting stress scale;Caregiver;LMICs
Document URI: http://hdl.handle.net/1942/49871
e-ISSN: 1471-244X
DOI: 10.1186/s12888-026-08235-2
ISI #: 001842236600003
Rights: The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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