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Title: Verapamil as prophylactic treatment for atrial fibrillation after lung operations
Authors: VAN MIEGHEM, Walter 
Tits, G.
Lacquet, L.
Deneffe, G.
Tjandra-maga, T.
Demedts, M.
Issue Date: 1996
Source: Annals of thoracic surgery, 61. p. 1083-1085
Abstract: Background. Atrial fibrillation is a frequently occurring arrhythmia after thoracic operations. Preventive strategies for this complication have been extensively evaluated after cardiac operations. Methods. We performed a prospective, open randomized study, comparing intravenous verapamil and placebo in 199 patients after pneumonectomy or lobectomy at the University Hospital of Leuven. Verapamil was administered as a bolus of 10 mg over 2 minutes followed by a 30-minute infusion of 0.375 mg/min and then 0.125 mg/min for 3 days. The patients were continuously monitored in the postoperative intensive care unit. Results. Atrial fibrillation occurred in 15% of the patients receiving placebo and in 8% of the patients receiving verapamil (difference not significant). The verapamil infusion was interrupted in 9% of the patients because of bradycardia and in 14% because of hypotension. Conclusions. If tolerated, continuous intravenous verapamil infusion showed only a modest prophylactic efficacy for the occurrence of atrial fibrillation after lung operations. In the dose employed the verapamil infusion was accompanied with a high incidence of side effects necessitating interruption of the therapy.
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Type: Journal Contribution
Appears in Collections:Non-affiliated authors

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