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http://hdl.handle.net/1942/5839
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DC Field | Value | Language |
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dc.contributor.author | Pastorino, U. | - |
dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | Friedel, G. | - |
dc.contributor.author | Ginsberg, R.J. | - |
dc.contributor.author | Girard, P. | - |
dc.contributor.author | Goldstraw, P. | - |
dc.contributor.author | Johnston, M. | - |
dc.contributor.author | McCormack, P. | - |
dc.contributor.author | Pass, H. | - |
dc.contributor.author | Putman, J.B. | - |
dc.date.accessioned | 2007-12-20T16:02:33Z | - |
dc.date.available | 2007-12-20T16:02:33Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Journal of thoracic cardiovascular surgery, 113(1). p. 37-49 | - |
dc.identifier.uri | http://hdl.handle.net/1942/5839 | - |
dc.description.abstract | Objectives: The International Registry of Lung Metastases was established in 1991 to assess the long-term results of pulmonary metastasectomy. Methods: The Registry has accrued 5206 cases of lung metastasectomy, from 18 departments of thoracic surgery in Europe (n = 13), the United States (n = 4) and Canada (n = 1). Of these patients, 4572 (88%) underwent complete surgical resection. The primary tumor was epithelial in 2260 cases, sarcoma in 2173, germ cell in 363, and melanoma in 328. The disease-free interval was 0 to 11 months in 2199 cases, 12 to 35 months in 1857, and more than 36 months in 1620. Single metastases accounted for 2383 cases and multiple lesions for 2726. Mean follow-up was 46 months. Analysis was performed by Kaplan-Meier estimates of survival, relative risks of death, and multivariate Cox model. Results: The actuarial survival after complete metastasectomy was 36% at 5 years, 26% at 10 years, and 22% at 15 years (median 35 months); the corresponding values for incomplete resection were 13% at 5 years and 7% at 10 years (median 15 months). Among complete resections, the 5-year survival was 33% for patients with a disease-free interval of 0 to 11 months and 45% for those with a disease-free interval of more than 36 months; 43% for single lesions and 27% for four or more lesions. Multivariate analysis showed a better prognosis for patients with germ cell tumors, disease-free intervals of 36 months or more, and single metastases. Conclusions: These results confirm that lung metastasectomy is a safe and potentially curative procedure. Resectability, disease-free interval, and number of metastases enabled us to design a simple system of classification valid for different tumor types. | - |
dc.language.iso | en | - |
dc.title | Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 49 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 37 | - |
dc.identifier.volume | 113 | - |
dc.bibliographicCitation.oldjcat | - | |
dc.identifier.url | http://jtcs.ctsnetjournals.org/cgi/content/abstract/113/1/37 | - |
item.fullcitation | Pastorino, U.; BUYSE, Marc; Friedel, G.; Ginsberg, R.J.; Girard, P.; Goldstraw, P.; Johnston, M.; McCormack, P.; Pass, H. & Putman, J.B. (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. In: Journal of thoracic cardiovascular surgery, 113(1). p. 37-49. | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
item.contributor | Pastorino, U. | - |
item.contributor | BUYSE, Marc | - |
item.contributor | Friedel, G. | - |
item.contributor | Ginsberg, R.J. | - |
item.contributor | Girard, P. | - |
item.contributor | Goldstraw, P. | - |
item.contributor | Johnston, M. | - |
item.contributor | McCormack, P. | - |
item.contributor | Pass, H. | - |
item.contributor | Putman, J.B. | - |
Appears in Collections: | Research publications |
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