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http://hdl.handle.net/1942/5980
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DC Field | Value | Language |
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dc.contributor.author | Braam, L.A.J.L.M. | - |
dc.contributor.author | Knapen, M.H.J. | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | Brouns, F. | - |
dc.contributor.author | Hamulyák, K. | - |
dc.contributor.author | Gerichhausen, M.J.W. | - |
dc.contributor.author | Vermeer, C. | - |
dc.date.accessioned | 2007-12-20T16:03:50Z | - |
dc.date.available | 2007-12-20T16:03:50Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Calcified tissue international, 73(1). p. 21-26 | - |
dc.identifier.issn | 0171-967X | - |
dc.identifier.uri | http://hdl.handle.net/1942/5980 | - |
dc.description.abstract | Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of the effect of vitamin K-1 supplementation on bone loss have been reported thus far. In the trial presented here we have investigated the potential complementary effect of vitamin K-1 (I mg/day) and a mineral + vitamin D supplement (8 mug/day) on postmenopausal bone loss. The design of our study was a randomized, double-blind, placebo-controlled intervention study; 181 healthy postmenopausal women between 50 and 60 years old were recruited, 155 of whom completed the study. During the 3-year treatment period, participants received a daily supplement containing either placebo, or calcium, magnesium.. zinc, and vitamin D (MD group), or the same formulation with additional vitamin K-1 (MDK group). The main outcome was the change in BMD of the femoral neck and lumbar spine after 3 years, as measured by DXA. The group receiving the supplement containing additional vitamin K-1 showed reduced bone loss of the femoral neck: after 3 years the difference between the MDK and the placebo group was 1.7% (95% Cl: 0.35-3.44) and that between the MDK and MD group was 1.3% (95% Cl: 0.10-3.41). No significant differences were observed among the three groups with respect to change of BMD at the site of the lumbar spine. If co-administered with minerals and vitamin D. vitamin K-1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG | - |
dc.subject.other | vitamin K; bone loss; osteoporosis; minerals; vitamin D | - |
dc.title | Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 26 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 21 | - |
dc.identifier.volume | 73 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1007/s00223-002-2084-4 | - |
dc.identifier.isi | 000184185100005 | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
item.validation | ecoom 2004 | - |
item.contributor | Braam, L.A.J.L.M. | - |
item.contributor | Knapen, M.H.J. | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | Brouns, F. | - |
item.contributor | Hamulyák, K. | - |
item.contributor | Gerichhausen, M.J.W. | - |
item.contributor | Vermeer, C. | - |
item.fullcitation | Braam, L.A.J.L.M.; Knapen, M.H.J.; GEUSENS, Piet; Brouns, F.; Hamulyák, K.; Gerichhausen, M.J.W. & Vermeer, C. (2003) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. In: Calcified tissue international, 73(1). p. 21-26. | - |
crisitem.journal.issn | 0171-967X | - |
crisitem.journal.eissn | 1432-0827 | - |
Appears in Collections: | Research publications |
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