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http://hdl.handle.net/1942/662
Title: | Analysis of photon count data from single-molecule fluorescence experiments | Authors: | BURZYKOWSKI, Tomasz SZUBIAKOWSKI, Jacek Ryden, T. |
Issue Date: | 2003 | Publisher: | ELSEVIER SCIENCE BV | Source: | Chemical Physics, 288(2-3). p. 291-307 | Abstract: | We consider single-molecule fluorescence experiments with data in the form of counts of photons registered over multiple time-intervals. Based on the observation schemes, linking back to works by Dehmelt [Bull. Am. Phys. Soc. 20 (1975) 60] and Cook and Kimble [Phys. Rev. Lett. 54 (1985) 1023], we propose an analytical approach to the data based on the theory of Markov-modulated Poisson processes (MMPP). In particular, we consider maximum-likelihood estimation. The method is illustrated using a real-life dataset. Additionally, the properties of the proposed method are investigated through simulations and compared to two other approaches developed by Yip et al. [J. Phys. Chem. A 102 (1998) 7564] and Molski [Chem. Phys. Lett. 324 (2000) 301]. | Document URI: | http://hdl.handle.net/1942/662 | ISSN: | 0301-0104 | e-ISSN: | 1873-4421 | DOI: | 10.1016/S0301-0104(03)00034-X | ISI #: | 000181550500016 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2004 |
Appears in Collections: | Research publications |
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