Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/7198
Title: | Effects of selenium supplementation on thyroid hormone metabolism in phenylketonuria subjects on a phenylalanine restricted diet | Authors: | Calomme, M. Vanderpas, J. FRANCOIS, Baudouin van Caillie-Bertrand, M. van Overvelt, N. Vanden Berghe, D. |
Issue Date: | 1995 | Publisher: | HUMANA PRESS INC | Source: | Biological trace element research, 47. p. 349-353 | Abstract: | Type I 5'-deiodinase was recently characterized as a selenocysteine-containing enzyme in humans and other mammals. Up to now, the effect of selenium (Se) supplementation on thyroid hormone metabolism in humans has only been reported in the very peculiar nutritional environment of Central Africa, where combined severe iodine and Se deficiency occurs. In this study, a group of phenylketonuria subjects with a low selenium status, but a normal iodine intake were supplemented with selenium to investigate changes in their thyroid hormone metabolism. After 3 wk of selenium supplementation (1 mu g/kg/d), both the concentrations of the prohormone thyroxine (T4) and the metabolic inactive reverse triiodothyronine (rT3) decreased significantly. Clinically, the phenylketonuria subjects remained euthyroid before and after selenium supplementation. The individual changes of plasma Se and glutathione peroxidase activity were closely associated with individual changes of plasma T4 and rT3. | Keywords: | PHENYLKETONURIA;SELENIUM;GLUTATHIONE PEROXIDASE;THYROID HORMONES;TYPE I IODOTHYRONINE DEIODINASE;SUPPLEMENTATION | Document URI: | http://hdl.handle.net/1942/7198 | DOI: | 10.1007/BF02790137 | ISI #: | WOS:A1995QK14900044 | Rights: | © 2020 Springer Nature Switzerland AG. Part of Springer Nature. | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Show full item record
WEB OF SCIENCETM
Citations
20
checked on May 8, 2024
Page view(s)
88
checked on Nov 7, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.