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Title: | Visualisation of the kinetics of macrophage infiltration during experimental autoimmune encephalomyelitis by magnetic resonance imaging | Authors: | BAETEN, Kurt HENDRIKS, Jerome HELLINGS, Niels THEUNISSEN, Evi VANDERLOCHT, Joris DE RYCK, Leen GELAN, Jan STINISSEN, Piet ADRIAENSENS, Peter |
Issue Date: | 2008 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF NEUROIMMUNOLOGY, 195(1-2). p. 1-6 | Abstract: | Macrophages are considered to be the predominant effector cells in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Ultra small particles of iron oxide (USPIO) can be used to detect macrophage infiltrates in the CNS with magnetic resonance imaging (MRI). Here, we investigated whether the kinetics of lesion formation in EAE can be visualised by altering the time point of USPIO injection and the time interval between particle injection and MRI. When USPIO are systemically injected 24 h before MRI, hypo intense regions are detected in different brain regions depending on the disease stage. These regions Correspond to sites of macrophage infiltration. A more complete visualisation of sites of inflammation is accomplished by USPIO injection at disease onset and postponing MRI to top of disease. This study demonstrates that the distribution pattern and amount of inflammatory lesions detected with USPIO, depends on timing of USPIO administration and subsequent MRI. These findings are important for a correct application and interpretation of USPIO dependent contrast imaging of CNS inflammation. (C) 2007 Elsevier B.V. All rights reserved. | Notes: | Hasselt Univ, Dept SBG, Inst Mat Res, IMO,Chem Div, B-3590 Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. | Keywords: | magnetic resonance imaging; experimental autoimmune encephalomyelitis; ultra small particles of iron oxide; multiple sclerosis;immunology; neurosciences | Document URI: | http://hdl.handle.net/1942/8319 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/j.jneuroim.2007.11.008 | ISI #: | 000255802000001 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2009 |
Appears in Collections: | Research publications |
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