Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8319
Title: Visualisation of the kinetics of macrophage infiltration during experimental autoimmune encephalomyelitis by magnetic resonance imaging
Authors: BAETEN, Kurt 
HENDRIKS, Jerome 
HELLINGS, Niels 
THEUNISSEN, Evi 
VANDERLOCHT, Joris 
DE RYCK, Leen 
GELAN, Jan 
STINISSEN, Piet 
ADRIAENSENS, Peter 
Issue Date: 2008
Publisher: ELSEVIER SCIENCE BV
Source: JOURNAL OF NEUROIMMUNOLOGY, 195(1-2). p. 1-6
Abstract: Macrophages are considered to be the predominant effector cells in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Ultra small particles of iron oxide (USPIO) can be used to detect macrophage infiltrates in the CNS with magnetic resonance imaging (MRI). Here, we investigated whether the kinetics of lesion formation in EAE can be visualised by altering the time point of USPIO injection and the time interval between particle injection and MRI. When USPIO are systemically injected 24 h before MRI, hypo intense regions are detected in different brain regions depending on the disease stage. These regions Correspond to sites of macrophage infiltration. A more complete visualisation of sites of inflammation is accomplished by USPIO injection at disease onset and postponing MRI to top of disease. This study demonstrates that the distribution pattern and amount of inflammatory lesions detected with USPIO, depends on timing of USPIO administration and subsequent MRI. These findings are important for a correct application and interpretation of USPIO dependent contrast imaging of CNS inflammation. (C) 2007 Elsevier B.V. All rights reserved.
Notes: Hasselt Univ, Dept SBG, Inst Mat Res, IMO,Chem Div, B-3590 Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
Keywords: magnetic resonance imaging; experimental autoimmune encephalomyelitis; ultra small particles of iron oxide; multiple sclerosis;immunology; neurosciences
Document URI: http://hdl.handle.net/1942/8319
ISSN: 0165-5728
e-ISSN: 1872-8421
DOI: 10.1016/j.jneuroim.2007.11.008
ISI #: 000255802000001
Category: A1
Type: Journal Contribution
Validations: ecoom 2009
Appears in Collections:Research publications

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