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http://hdl.handle.net/1942/8871
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DC Field | Value | Language |
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dc.contributor.advisor | BURZYKOWSKI, Tomasz | - |
dc.contributor.advisor | MOLENBERGHS, Geert | - |
dc.contributor.author | CORTINAS ABRAHANTES, Jose | - |
dc.date.accessioned | 2008-12-03T19:16:12Z | - |
dc.date.available | 2008-12-03T19:16:12Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://hdl.handle.net/1942/8871 | - |
dc.description.abstract | In this dissertation we have considered several issues related to the estimation of mixed effects models. In Chapters 2 and 3 we have evaluated the performance of the simplified strategies, and also the impact of ignoring a level in fitting linear mixed effects models for normally distributed data. In Chapter 4 we have briefly illustrated some methodological issues related to the use of mixed effects models for failure-time data, as well as several estimation procedures to fit the models. In Chapter 5, we have proposed a novel modification of the EM algorithm, in which the Laplace approximation is used at the E-step. We have conducted a simulation study (Chapter 6) to evaluate the performance of the proposed estimation procedure and to compare it with alternative approaches. Finally, in Chapter 7 we have investigated the possibility of using simplified strategies in the meta-analytic approach to the validation of surrogate endpoints in the case of two failure-times. | - |
dc.publisher | UHasselt Diepenbeek | - |
dc.title | Estimation procedures for mixed-effects models with applications to normally distributed and survival data | - |
dc.type | Theses and Dissertations | - |
local.bibliographicCitation.jcat | T1 | - |
local.type.specified | Phd thesis | - |
dc.bibliographicCitation.oldjcat | D1 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | CORTINAS ABRAHANTES, Jose (2004) Estimation procedures for mixed-effects models with applications to normally distributed and survival data. | - |
item.accessRights | Open Access | - |
item.contributor | CORTINAS ABRAHANTES, Jose | - |
Appears in Collections: | PhD theses Research publications |
Files in This Item:
File | Description | Size | Format | |
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CortinasAbrahantesJose.pdf | 1.86 MB | Adobe PDF | View/Open |
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