Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/8997
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jansen, Jacobus F. A. | - |
dc.contributor.author | LEMMENS, Evi | - |
dc.contributor.author | Strijkers, Gustav J. | - |
dc.contributor.author | Prompers, Jeanine J. | - |
dc.contributor.author | Schijns, Olaf E. M. G. | - |
dc.contributor.author | Kooi, M. Eline | - |
dc.contributor.author | BEULS, Emile | - |
dc.contributor.author | Nicolay, Klaas | - |
dc.contributor.author | Backes, Walter H. | - |
dc.contributor.author | HOOGLAND, Govert | - |
dc.date.accessioned | 2008-12-09T10:03:56Z | - |
dc.date.available | 2008-12-09T10:03:56Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | NEUROBIOLOGY OF DISEASE, 32(2). p. 293-301 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | http://hdl.handle.net/1942/8997 | - |
dc.description.abstract | Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject.other | Experimental febrile seizures; Hyperthermia; MR1; Neuroimaging; Diffusion; Anisotropy; Histology | - |
dc.title | Short- and long-term limbic abnormalities after experimental febrile seizures | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 301 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 293 | - |
dc.identifier.volume | 32 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Lemmens, Evi M. P.; Schijns, Olaf E. M. G.; Beuls, Emile A. M.; Hoogland, Govert] Maastricht Univ Hosp, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands. [Jansen, Jacobus F. A.; Kooi, M. Eline; Backes, Walter H.] Maastricht Univ Hosp, Dept Radiol, NL-6202 AZ Maastricht, Netherlands. [Jansen, Jacobus F. A.; Strijkers, Gustav J.; Prompers, Jeanine J.; Nicolay, Klaas] Eindhoven Univ Technol, Biomed NMR, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands. [Lemmens, Evi M. P.] Maastricht Univ, Div Neurosci, Sch Mental Hlth & Neurosci, Maastricht, Netherlands. [Beuls, Emile A. M.] Hasselt Univ, Dept Anat & Mat Res, Diepenbeek, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/j.nbd.2008.07.010 | - |
dc.identifier.isi | 000260549100011 | - |
item.accessRights | Closed Access | - |
item.validation | ecoom 2009 | - |
item.contributor | Jansen, Jacobus F. A. | - |
item.contributor | LEMMENS, Evi | - |
item.contributor | Strijkers, Gustav J. | - |
item.contributor | Prompers, Jeanine J. | - |
item.contributor | Schijns, Olaf E. M. G. | - |
item.contributor | Kooi, M. Eline | - |
item.contributor | BEULS, Emile | - |
item.contributor | Nicolay, Klaas | - |
item.contributor | Backes, Walter H. | - |
item.contributor | HOOGLAND, Govert | - |
item.fulltext | No Fulltext | - |
item.fullcitation | Jansen, Jacobus F. A.; LEMMENS, Evi; Strijkers, Gustav J.; Prompers, Jeanine J.; Schijns, Olaf E. M. G.; Kooi, M. Eline; BEULS, Emile; Nicolay, Klaas; Backes, Walter H. & HOOGLAND, Govert (2008) Short- and long-term limbic abnormalities after experimental febrile seizures. In: NEUROBIOLOGY OF DISEASE, 32(2). p. 293-301. | - |
crisitem.journal.issn | 0969-9961 | - |
crisitem.journal.eissn | 1095-953X | - |
Appears in Collections: | Research publications |
SCOPUSTM
Citations
18
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
20
checked on Jul 18, 2024
Page view(s)
62
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.