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http://hdl.handle.net/1942/9026
Title: | Design of a new pulsatile bioreactor for tissue engineered aortic heart valve formation | Authors: | Dumont, K YPERMAN, Jan Verbeken, E Segers, P Meuris, Bart Vandenberghe, S Flameng, W Verdonck, PR |
Issue Date: | 2002 | Publisher: | BLACKWELL PUBLISHING INC | Source: | ARTIFICIAL ORGANS, 26(8). p. 710-714 | Abstract: | Evidence has been gathered that biomechanical factors have a significant impact on cell differentiation and behavior in in vitro cell cultures. The aim of this bioreactor is to create a physiological environment in which tissue engineered (TE) aortic valves seeded with human cells can be cultivated during a period of several days. The bioreactor consists of 2 major parts: the left ventricle (LV) and the afterload consisting of a compliance, representing the elastic function of the large arteries, and in series a resistance, mimicking the arterioles and capillaries. The TE aortic valve is placed between the LV and the compliance. With controllable resistance, compliance, stroke volume and frequency, and hydrodynamic conditions can be changed over a wide physiological range. This study resulted in a prototype of a compact pulsatile flow system for the creation of TE aortic valves. In addition a biocompatibility study of the used materials is performed. | Notes: | State Univ Ghent, Inst Biomed Technol, Hydraul Lab, B-9000 Ghent, Belgium. Katholieke Univ Leuven, Ctr Expt Surg & Anesthesiol, CEHA, Louvain, Belgium. Katholieke Univ Leuven, Div Morphol & Mol Pathol, Louvain, Belgium. | Keywords: | pulsatile bioreactor; tissue engineering; aortic valve; biocompatibility; cardiovascular mechanics | Document URI: | http://hdl.handle.net/1942/9026 | ISSN: | 0160-564X | e-ISSN: | 1525-1594 | ISI #: | 000177080800009 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2003 |
Appears in Collections: | Research publications |
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