Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9080
Title: Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages
Authors: HENDRIKS, Jerome 
SLAETS, Leen 
CARMANS, Sofie 
de Vries, Helga
Dijkstra, Christine
STINISSEN, Piet 
HELLINGS, Niels 
Issue Date: 2008
Publisher: ELSEVIER SCIENCE BV
Source: JOURNAL OF NEUROIMMUNOLOGY, 204(1-2). p. 52-57
Abstract: Leukemia inhibitory factor (LIF) promotes survival of glial cells and neurons during autoimmune and injury responses in the central nervous system (CNS). While various Studies indicate that LIF also modulates ongoing inflammatory responses, data on underlying events are lacking. In this study we demonstrate that LIF modulates macrophage function. LIF inhibits the production of oxygen radicals and TNFalpha and stimulates myelin uptake by macrophages. These effects of LIF are accompanied by activation of the JAK/STAT3 signalling pathway. Our findings demonstrate that LIF has anti-inflammatory properties and enhances myelin clearance, implicating that LIF may be an important factor in CNS inflammatory disease. (C) 2008 Elsevier B.V. All rights reserved.
Notes: [Hendriks, Jerome J. A.; Slaets, Helena; Carmans, Sofie; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Hendriks, Jerome J. A.; Slaets, Helena; Carmans, Sofie; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [de Vries, Helga E.; Dijkstra, Christine D.] MF, VUmc, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands.
Keywords: Macrophage; Multiple sclerosis; Myelin; Phagocytosis; Leukemia inhibitory factor;immunology; neurosciences
Document URI: http://hdl.handle.net/1942/9080
ISSN: 0165-5728
e-ISSN: 1872-8421
DOI: 10.1016/j.jneuroim.2008.07.015
ISI #: 000261270700007
Category: A1
Type: Journal Contribution
Validations: ecoom 2009
Appears in Collections:Research publications

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