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Title: | Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages | Authors: | HENDRIKS, Jerome SLAETS, Leen CARMANS, Sofie de Vries, Helga Dijkstra, Christine STINISSEN, Piet HELLINGS, Niels |
Issue Date: | 2008 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF NEUROIMMUNOLOGY, 204(1-2). p. 52-57 | Abstract: | Leukemia inhibitory factor (LIF) promotes survival of glial cells and neurons during autoimmune and injury responses in the central nervous system (CNS). While various Studies indicate that LIF also modulates ongoing inflammatory responses, data on underlying events are lacking. In this study we demonstrate that LIF modulates macrophage function. LIF inhibits the production of oxygen radicals and TNFalpha and stimulates myelin uptake by macrophages. These effects of LIF are accompanied by activation of the JAK/STAT3 signalling pathway. Our findings demonstrate that LIF has anti-inflammatory properties and enhances myelin clearance, implicating that LIF may be an important factor in CNS inflammatory disease. (C) 2008 Elsevier B.V. All rights reserved. | Notes: | [Hendriks, Jerome J. A.; Slaets, Helena; Carmans, Sofie; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Hendriks, Jerome J. A.; Slaets, Helena; Carmans, Sofie; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [de Vries, Helga E.; Dijkstra, Christine D.] MF, VUmc, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands. | Keywords: | immunology; neurosciences;Macrophage; Multiple sclerosis; Myelin; Phagocytosis; Leukemia inhibitory factor | Document URI: | http://hdl.handle.net/1942/9080 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/j.jneuroim.2008.07.015 | ISI #: | 000261270700007 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2009 |
Appears in Collections: | Research publications |
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