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http://hdl.handle.net/1942/9085
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DC Field | Value | Language |
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dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Van Hecke, Etienne | - |
dc.contributor.author | Thijs, Lutgarde | - |
dc.contributor.author | Richart, Tom | - |
dc.contributor.author | Kuznetsova, Tatiana | - |
dc.contributor.author | Jin, Yu | - |
dc.contributor.author | VANGRONSVELD, Jaco | - |
dc.contributor.author | ROELS, Harry | - |
dc.contributor.author | Staessen, Jan A. | - |
dc.date.accessioned | 2009-01-05T13:35:04Z | - |
dc.date.available | 2009-01-05T13:35:04Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | ENVIRONMENTAL HEALTH PERSPECTIVES, 116(12). p. 1620-1628 | - |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | http://hdl.handle.net/1942/9085 | - |
dc.description.abstract | BACKGROUND: Few population studies have reported on the long-term changes in the internal cadmium dose and simultaneously occurring mortality. OBJECTIVE: We monitored blood cadmium (BCd), 24-hr urinary cadmium (UCd), and mortality in an environmentally exposed population. METHODS: Starting from 1985, we followed BCd (until 2003), UCd (until 1996), and mortality (until 2007) among 476 and 480 subjects, randomly recruited from low- exposure areas (LEA) and high-exposure areas (HEA). The last cadmium-producing plant in the HEA closed in 2002. RESULTS: From 1985-1989 to 1991-1996, BCd decreased by 40.3% and 18.9% in the LEA and HEA, respectively (p < 0.0001 for between-area difference). From 1991-1996 until 2001-2003, BCd remained unchanged in the HEA (+ 1.8%) and increased by 19.7% in the LEA (p < 0.0001). Over the entire follow-up period, the annual decrease in BCd averaged 2.7% in the LEA (n = 258) and 1.8% in the HEA (n = 203). From 1985-1989 to 1991-1996, UCd fell by 12.9% in the LEA and by 16.6% in the HEA (p = 0.22), with mean annual decreases of 2.7% (n = 366) and 3.4% (n = 364). Over 20.3 years (median), 206 deaths (21.5%) occurred. At baseline, BCd (14.6 vs. 10.2 nmol/L) and UCd (14.1 vs. 8.6 nmol/24-hr) were higher in deaths than in survivors. The risks (p <= 0.04) associated with a doubling of baseline UCd were 20% and 44% for total and noncardiovascular mortality, and 25% and 33% for a doubling of BCd. CONCLUSIONS: Even if zinc-cadmium smelters close, historical environmental contamination remains a persistent source of exposure. Environmental exposure to cadmium increases total and noncardiovascular mortality in a continuous fashion without threshold. | - |
dc.language.iso | en | - |
dc.publisher | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | - |
dc.subject.other | cadmium; environmental exposure; mortality | - |
dc.subject.other | cadmium; environmental exposure; mortality | - |
dc.title | Cadmium-Related Mortality and Long-Term Secular Trends in the Cadmium Body Burden of an Environmentally Exposed Population | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1628 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1620 | - |
dc.identifier.volume | 116 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Nawrot, Tim S.; Thijs, Lutgarde; Richart, Tom; Kuznetsova, Tatiana; Jin, Yu; Staessen, Jan A.] Katholieke Univ Leuven, Studies Coordinating Ctr, Div Hypertens & Cardiovasc Rehabil, Lab Hypertens,Dept Cardiovasc Dis, B-3000 Leuven, Belgium. [Nawrot, Tim S.; Vangronsveld, Jaco] Univ Hasselt, Dept Environm Biol, Diepenbeek, Belgium. [Richart, Tom; Staessen, Jan A.] Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands. [Roels, Harry A.] Univ Catholique Louvain, Ind Toxicol & Occupat Med Unit, B-1200 Brussels, Belgium. [Van Hecke, Etienne] Katholieke Univ Leuven, Dept Earth & Environm Sci, Social & Geog Sect, B-3000 Leuven, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Dept Occupat & Environm Med, Sch Publ Hlth, B-3000 Leuven, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1289/ehp.11667 | - |
dc.identifier.isi | 000261290300022 | - |
item.validation | ecoom 2009 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | NAWROT, Tim; Van Hecke, Etienne; Thijs, Lutgarde; Richart, Tom; Kuznetsova, Tatiana; Jin, Yu; VANGRONSVELD, Jaco; ROELS, Harry & Staessen, Jan A. (2008) Cadmium-Related Mortality and Long-Term Secular Trends in the Cadmium Body Burden of an Environmentally Exposed Population. In: ENVIRONMENTAL HEALTH PERSPECTIVES, 116(12). p. 1620-1628. | - |
item.accessRights | Open Access | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Van Hecke, Etienne | - |
item.contributor | Thijs, Lutgarde | - |
item.contributor | Richart, Tom | - |
item.contributor | Kuznetsova, Tatiana | - |
item.contributor | Jin, Yu | - |
item.contributor | VANGRONSVELD, Jaco | - |
item.contributor | ROELS, Harry | - |
item.contributor | Staessen, Jan A. | - |
crisitem.journal.issn | 0091-6765 | - |
crisitem.journal.eissn | 1552-9924 | - |
Appears in Collections: | Research publications |
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picrender.pdf | Published version | 181.77 kB | Adobe PDF | View/Open |
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