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http://hdl.handle.net/1942/9215
Title: | New Concepts on the Pathogenesis of Autoimmune Diseases: A Role for Immune Homeostasis, Immunoregulation, and Immunosenescence | Authors: | THEWISSEN, Marielle STINISSEN, Piet |
Issue Date: | 2008 | Publisher: | BEGELL HOUSE INC | Source: | CRITICAL REVIEWS IN IMMUNOLOGY, 28(5). p. 363-376 | Abstract: | Complex autoimmune diseases are chronic conditions initiated by a loss of immunological tolerance to self-antigens. Despite many years of intense investigation, the etiopathogenic mechanisms initiating these chronic inflammatory conditions remain undefined. The relatively high prevalence and the clustering of multiple autoimmune diseases within individuals or within families suggest that rather common immune mechanisms may facilitate the development of autoimmune diseases. However, specific genetic or environmental factors seem to be necessary for triggering disease. Clearly, immune mechanisms, which are intended to protect from disease, fail or become dysregulated. In this review, we discuss the mechanisms of immune homeostasts, immune regulation, and immunosenescence. We focus on the merit, consequences, and/or shortcomings of these mechanisms and speculate on their possible involvement in autoimmune-disease development. | Notes: | [Thewissen, Marielle; Stinissen, Piet] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Thewissen, Marielle; Stinissen, Piet] Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. [Thewissen, Marielle] Maastricht Univ, Dept Internal Med, Div Clin & Expt Immunol, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands. | Keywords: | thymic involution; lymphopenia; CD4(+)CD28(null) T cells | Document URI: | http://hdl.handle.net/1942/9215 | ISSN: | 1040-8401 | e-ISSN: | 2162-6472 | ISI #: | 000262059000001 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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