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http://hdl.handle.net/1942/9221
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DC Field | Value | Language |
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dc.contributor.author | VANGENEUGDEN, Tony | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | LAENEN, Annouschka | - |
dc.contributor.author | ALONSO ABAD, Ariel | - |
dc.contributor.author | GEYS, Helena | - |
dc.date.accessioned | 2009-02-02T13:53:32Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 18(4). p. 691-712 | - |
dc.identifier.issn | 1054-3406 | - |
dc.identifier.uri | http://hdl.handle.net/1942/9221 | - |
dc.description.abstract | This work investigates how generalizability, an extension of reliability, can be defined and estimated based on longitudinal data sequences resulting from, for example, clinical studies. Useful and intuitive approximate expressions are derived based on generalized linear mixed models. Data from four double-blind, randomized clinical trials into schizophrenia motivate the research and are used to estimate generalizability for a binary response parameter. | - |
dc.description.sponsorship | The authors are thankful to J&J PRD for their kind permission to use their data. Financial support from the IAP research network #P6/03 of the Belgian Government (Belgian Science Policy) is gratefully acknowledged. | - |
dc.format.extent | 213217 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject.other | binary data; generalizability; intraclass correlation; random effects; reliability; variance component | - |
dc.title | Generalizability in non-Gaussian longitudinal clinical trial data based on generalized linear mixed models | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 712 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 691 | - |
dc.identifier.volume | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1080/10543400802071386 | - |
dc.identifier.isi | 000257438900010 | - |
item.contributor | VANGENEUGDEN, Tony | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | LAENEN, Annouschka | - |
item.contributor | ALONSO ABAD, Ariel | - |
item.contributor | GEYS, Helena | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2009 | - |
item.fullcitation | VANGENEUGDEN, Tony; MOLENBERGHS, Geert; LAENEN, Annouschka; ALONSO ABAD, Ariel & GEYS, Helena (2007) Generalizability in non-Gaussian longitudinal clinical trial data based on generalized linear mixed models. In: JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 18(4). p. 691-712. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1054-3406 | - |
crisitem.journal.eissn | 1520-5711 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
GeertMolenberghs7.pdf | Peer-reviewed author version | 208.22 kB | Adobe PDF | View/Open |
a.pdf Restricted Access | Published version | 176.36 kB | Adobe PDF | View/Open Request a copy |
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