Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9253
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dc.contributor.authorTILAHUN ESHETE, Abel-
dc.contributor.authorMARINGWA, John-
dc.contributor.authorGEYS, Helena-
dc.contributor.authorALONSO ABAD, Ariel-
dc.contributor.authorRaeymaekers, Leen-
dc.contributor.authorMOLENBERGHS, Geert-
dc.contributor.authorVan Den Kieboom, Gerd-
dc.contributor.authorDrinkenburg, Pim-
dc.contributor.authorBIJNENS, Luc-
dc.date.accessioned2009-02-16T08:37:13Z-
dc.date.availableNO_RESTRICTION-
dc.date.issued2009-
dc.identifier.citationJOURNAL OF BIOPHARMACEUTICAL STATISTICS, 19(1). p. 133-149-
dc.identifier.issn1054-3406-
dc.identifier.urihttp://hdl.handle.net/1942/9253-
dc.description.abstractThe drug development process involves identifying a compound and assessing its merit through rigorous pre-clinical and clinical trials. The pre-clinical stage is designed to assess the chemical properties of the new drug, as well as to determine the steps for synthesis and purification. In this stage of drug development, circumstances might dictate the use of alternative endpoints than the originally anticipated clinically relevant endpoint. In this regard, identification and evaluation of surrogate endpoints is of paramount importance. The validation methods make it possible to quantify degrees of association between the clinically relevant endpoint, also termed the true endpoint, and the alternative, surrogate endpoint. In this paper, we adapt the surrogate marker evaluation methodology of Alonso et al. (2003); (2006), developed for the case of two longitudinal outcomes, to the situation where either a longitudinal surrogate and cross sectional true endpoint is recorded, or vice versa. The work is motivated by a preclinical experiment conducted to assess association between corticosterone (CORT), heart rate, and blood pressure in rats, the data from which are then subjected to analysis. It was found that there is a weak relationship between CORT and behavior, and between CORT on the one hand and heart rate and blood pressure on the other hand, but a reasonably high degree of association was registered between heart rate and behavior.-
dc.description.sponsorshipFinancial support from the IAP research network #P6/03 of the Belgian Government (Belgian Science Policy) is gratefully acknowledged.-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS INC-
dc.rightsCopyright © Taylor & Francis Group, LLC-
dc.subject.otherfractional polynomial; R² Λ ; spline; surrogate endpoint; true endpoint; variance reduction factor-
dc.subject.otherFractional polynomial; R2; Spline; Surrogate endpoint; True endpoint; Variance reduction factor-
dc.titleInvestigating Association Between Behavior, Corticosterone, Heart Rate, and Blood Pressure in Rats Using Surrogate Marker Evaluation Methodology-
dc.typeJournal Contribution-
dc.identifier.epage149-
dc.identifier.issue1-
dc.identifier.spage133-
dc.identifier.volume19-
local.format.pages17-
local.bibliographicCitation.jcatA1-
dc.description.notes[Tilahun, Abel; Maringwa, John T.; Alonso, Ariel; Molenberghs, Geert] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. [Geys, Helena; Raeymaekers, Leen; Kieboom, Gerd Van Den; Drinkenburg, Pim; Bijnens, Luc] Johnson & Johnson Pharmaceut Res & Dev, Beerse, Belgium.-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1080/10543400802527924-
dc.identifier.isi000262247900013-
item.fullcitationTILAHUN ESHETE, Abel; MARINGWA, John; GEYS, Helena; ALONSO ABAD, Ariel; Raeymaekers, Leen; MOLENBERGHS, Geert; Van Den Kieboom, Gerd; Drinkenburg, Pim & BIJNENS, Luc (2009) Investigating Association Between Behavior, Corticosterone, Heart Rate, and Blood Pressure in Rats Using Surrogate Marker Evaluation Methodology. In: JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 19(1). p. 133-149.-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.validationecoom 2010-
item.contributorALONSO ABAD, Ariel-
item.contributorDrinkenburg, Pim-
item.contributorRaeymaekers, Leen-
item.contributorTILAHUN ESHETE, Abel-
item.contributorMARINGWA, John-
item.contributorMOLENBERGHS, Geert-
item.contributorGEYS, Helena-
item.contributorVan Den Kieboom, Gerd-
item.contributorBIJNENS, Luc-
crisitem.journal.issn1054-3406-
crisitem.journal.eissn1520-5711-
Appears in Collections:Research publications
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