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Title: Striatal PSA-NCAM(+) precursor cells from the newborn rat express functional glycine receptors
Authors: Nguyen, L
Malgrange, B.
Breuskin, I
Lallemend, F
Hans, G
Moonen, G
Belachew, S.
RIGO, Jean-Michel 
Issue Date: 2004
Source: NEUROREPORT, 15(4). p. 583-587
Abstract: Immunocytochemical analysis showed that ionotropic glycine receptors are expressed in neurogenic progenitors purified from the newborn rat striatum and expressing the polysialylated form of the neural cell adhesion molecule, both in vitro and in situ. To ascertain whether glycine receptors were functional in vitro, whole-cell patch-clamp recordings demonstrated that glycine triggers inward strychnine-sensitive currents in the majority of these cells. Moreover, we found that glycine receptors expressed by these neurogenic progenitors display intermediate electrophysiological characteristics between those of glycine receptors expressed by neural stem cells and by mature interneurons from the rat striatum. Altogether, the present data show that functional strychnine-sensitive glycine receptors are expressed in neurogenic progenitors purified from the newborn rat striatum.
Notes: Univ Liege, Ctr Cellular & Mol Neurobiol, B-4020 Liege, Belgium. Univ Liege, CHU, Dept Neurol, B-4000 Liege, Belgium.
Keywords: glycine receptors; immunocytochemistry; neuroblast; newborn rat; PSA-NCAM; strychnine; whole-cell patch-clamp
Document URI:
ISSN: 0959-4965
e-ISSN: 1473-558X
DOI: 10.1097/01.wnr.0000094860.49817.dd
ISI #: 000225140100003
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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