Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/9553
Title: | Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes | Authors: | Nia, Peyman Sardari Colpaert, Cecile Vermeulen, Peter WEYLER, Joost Pezzella, Francesco Van Schil, Paul Van Marck, Eric |
Issue Date: | 2008 | Publisher: | ELSEVIER SCIENCE INC | Source: | ANNALS OF THORACIC SURGERY, 85(2). p. 395-405 | Abstract: | Background. We have recently shown the prognostic value of growth pattern classification in non-small cell lung cancer. The aim of this study is to validate the hypothesis that these growth patterns have a distinct angiogenic and proliferative profile. Methods. Hematoxylin-eosin stained tissue sections of 239 patients with non-small cell lung cancer were classified into growth patterns. One representative tissue section per patient was double immunostained with CD34 and Ki-67 antibodies. Endothelial cell proliferation fraction, tumor cell proliferation fraction, microvessel density, and Chalkley count were assessed at the invading front and the center of the selected tumor section. Results. According to the growth pattern classification, 161 patients (67.4%) had a destructive, 33 (13.8%) a papillary, and 45 (18.8%) an alveolar growth pattern. There were significant differences in endothelial cell proliferation fraction (p < 0.001), tumor cell proliferation fraction (p < 0.001), microvessel density (p < 0.001), and Chalkley count (p < 0.001) between the growth patterns. Multiple Cox regression analysis showed that a low endothelial cell proliferation fraction was consistently an independent prognostic factor for overall poor (hazard ratio = 0.93; confidence interval: 0.88 to 0.97, p = 0.002) and disease-free survival (hazard ratio = 0.94; confidence interval: 0.89 to 0.98, p = 0.007). Conclusions. Growth patterns have a distinct angiogenic and proliferative profile. In non-small cell lung cancer, a low degree of angiogenesis (a low endothelial cell proliferation fraction) is associated with poor prognosis. | Notes: | Univ Antwerp Hosp, Dept Thorac & Vasc Surg, Antwerp, Belgium. Univ Antwerp Hosp, Dept Pathol, Antwerp, Belgium. Univ Antwerp Hosp, Dept Epidemiol, Antwerp, Belgium. Univ Antwerp Hosp, Dept Social Med, Antwerp, Belgium. John Radcliffe Hosp, Canc Res Tumor Pathol Grp, Oxford OX3 9DU, England. | Keywords: | LYMPH-NODE METASTASES; TUMOR ANGIOGENESIS; PROGNOSTIC VALUE; BREAST-CANCER; CARCINOMA; SURVIVAL; EXPRESSION | Document URI: | http://hdl.handle.net/1942/9553 | ISSN: | 0003-4975 | e-ISSN: | 1552-6259 | DOI: | 10.1016/j.athoracsur.2007.08.054 | ISI #: | 000252664900007 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
Show full item record
SCOPUSTM
Citations
20
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
31
checked on Apr 30, 2024
Page view(s)
68
checked on Jul 28, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.