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Title: | Spine radiographs to improve the identification of women at high risk for fractures | Authors: | Netelenbos, J. C. Lems, W. F. GEUSENS, Piet Verhaar, H. J. Boermans, A. J. M. Boomsma, M. M. Mulder, P. G. H. Papapoulos, S. E. |
Issue Date: | 2009 | Publisher: | SPRINGER LONDON LTD | Source: | OSTEOPOROSIS INTERNATIONAL, 20(8). p. 1347-1352 | Abstract: | In women older than 60 years with clinical risk factors for osteoporosis but without osteoporosis based on bone mineral density (T-score a parts per thousand yenaEuro parts per thousand a'2.5), a systematic survey with X-rays of the spine identified previously unknown vertebral deformities in 21% of women. This study determines the prevalence of vertebral deformities in elderly women with clinical risk factors for osteoporosis but with BMD values above the threshold for osteoporosis (T-score a parts per thousand yenaEuro parts per thousand a'2.5). Bisphosphonate na < ve women older than 60 years attending 35 general practices in the Netherlands with a parts per thousand yen2 clinical risk factors for osteoporosis were invited for BMD measurement (DXA). In women with T-score a parts per thousand yenaEuro parts per thousand a'2.5 at both spine and the hips, lateral radiographs of the thoracic and lumbar spine were performed. Of 631 women with a DXA measurement, 187 (30%) had osteoporosis (T-score < -2.5 at the spine or the hip). Of the remaining 444 women with T-score a parts per thousand yenaEuro parts per thousand a'2.5 at both spine and hip, 387 had additional spine radiographs, of whom 80 (21%) had at least one vertebral deformity. In elderly women with clinical risk factors for osteoporosis but BMD T-score a parts per thousand yenaEuro parts per thousand a'2.5, addition of spine radiographs identified vertebral deformities in 21% (95% CI: 17-25). Since these women are at risk of future fractures, antiosteoporotic treatment should be considered. | Notes: | [Netelenbos, J. C.] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, NL-1081 HV Amsterdam, Netherlands. [Lems, W. F.] Vrije Univ Amsterdam, Med Ctr, Dept Rheumatol, NL-1081 HV Amsterdam, Netherlands. [Geusens, P. P.] Univ Hosp, Dept Internal Med Rheumatol, Maastricht, Netherlands. [Geusens, P. P.] Univ Hasselt, Hasselt, Belgium. [Verhaar, H. J.] Univ Med Ctr, Dept Geriatr Med, Mobil Lab, Utrecht, Netherlands. [Boomsma, M. M.] GlaxoSmithKline Inc, Dept Med, Zeist, Netherlands. [Mulder, P. G. H.] Erasmus Univ, Med Ctr, Rotterdam, Netherlands. [Papapoulos, S. E.] Univ Med Ctr, Dept Endocrinol & Metab Dis, Leiden, Netherlands. | Keywords: | Bone mineral density; Case finding; Dual-energy X-ray absorptiometry; Spine radiographs | Document URI: | http://hdl.handle.net/1942/9790 | ISSN: | 0937-941X | e-ISSN: | 1433-2965 | DOI: | 10.1007/s00198-008-0801-1 | ISI #: | 000267915200009 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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