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http://hdl.handle.net/1942/9813
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DC Field | Value | Language |
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dc.contributor.author | SLAETS, Leen | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.contributor.author | de Vries, Helga | - |
dc.contributor.author | Baekelandt, Veerle | - |
dc.contributor.author | Van den Haute, Chris | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2009-08-19T12:49:04Z | - |
dc.date.available | WITHHELD_ONE_YEAR | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | CLINICAL IMMUNOLOGY, 131. p. S34-S34 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | http://hdl.handle.net/1942/9813 | - |
dc.description.abstract | The neuropoietic cytokine oncostatin M (OSM) is expressed in MS lesions, but its function during CNS lesion development is unknown. In order to elucidate the effects of OSM in the CNS, we have induced local expression of mouse OSM in the CNS of C57/Bl6 mice by means of lentiviral vectors and compared the effects of OSM to those of local expression of another neurokine family member leukemia inhibitory factor (LIF). We found that at sites of OSM expression, substantial tissue remodelling occurs, the blood-brain barrier (BBB) is disrupted and serum leaks into the CNS parenchyma. Endothelial cells of the BBB showed a dramatic upregulation of adhesion molecules. None of these effects were detected after CNS-directed expression of LIF. Moreover, local expression of OSM in the healthy CNS induced a strong expression of MHCII and attracted large amounts of T-cells and macrophages/microglia to the CNS. Our study indentified OSM as a pathological neurokine with the potential to induce neuroinflammation in the healthy CNS. | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Oncostatin M is a Potent Inducer of CNS Inflammation | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.conferencename | 9th Annual Meeting of the Federation-of-Clinical-Immunology-Societies | - |
local.bibliographicCitation.conferenceplace | San Francisco, CA, JUN 11-14, 2009 | - |
dc.identifier.epage | S34 | - |
dc.identifier.spage | S34 | - |
dc.identifier.volume | 131 | - |
local.format.pages | 1 | - |
local.bibliographicCitation.jcat | M | - |
dc.description.notes | [Slaets, Helena; Hendriks, Jerome; Stinissen, P.; Hellings, Niels] Univ Limburg, Hasselt Univ & Transnatl, Diepenbeek, Belgium. [Baekelandt, Veerle; Van den Haute, Chris] Katholieke Univ Leuven, Louvain, Belgium. [de Vries, Helga] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A5 | - |
dc.identifier.doi | 10.1016/j.clim.2009.03.095 | - |
dc.identifier.isi | 000266342300090 | - |
item.accessRights | Open Access | - |
item.fullcitation | SLAETS, Leen; HENDRIKS, Jerome; de Vries, Helga; Baekelandt, Veerle; Van den Haute, Chris; STINISSEN, Piet & HELLINGS, Niels (2009) Oncostatin M is a Potent Inducer of CNS Inflammation. In: CLINICAL IMMUNOLOGY, 131. p. S34-S34. | - |
item.fulltext | With Fulltext | - |
item.contributor | SLAETS, Leen | - |
item.contributor | HENDRIKS, Jerome | - |
item.contributor | de Vries, Helga | - |
item.contributor | Baekelandt, Veerle | - |
item.contributor | Van den Haute, Chris | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | HELLINGS, Niels | - |
crisitem.journal.issn | 1521-6616 | - |
crisitem.journal.eissn | 1521-7035 | - |
Appears in Collections: | Research publications |
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