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Title: | Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil | Authors: | Janssen, Sofie P. M. Phernambucq, Marko Martinez-Martinez, Pilar DE BAETS, Marc Losen, Mario |
Issue Date: | 2008 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF NEUROIMMUNOLOGY, 201. p. 111-120 | Abstract: | Currently used non-specific immunosuppresive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate mofetil (MMF) in experimental autoimmune MG (EAMG), rats were immunized with acetylcholine receptors (AChRs) and subsequently treated with MMF or vehicle. MMF treatment resulted in a significant suppression of anti-rat AChR antibody titers. Interestingly, no abnormalities of neuromuscular transmission and adverse side effects were detected in MMF-treated EAMG animals. Moreover, anti-rat AChR antibody titers correlated to an improvement of clinical outcome. In conclusion, our data suggest that MMF acts as a potent immunosuppressant drug in EAMG. (C) 2008 Elsevier B.V All rights reserved. | Notes: | [Janssen, Sofie P. M.; Phernambucq, Marko; Martinez-Martinez, Pilar; De Baets, Marc H.; Losen, Mario] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, Dept Neurosci, NL-6200 MD Maastricht, Netherlands. [De Baets, Marc H.] Hasselt Univ, Biomed Res Inst BIOMED, Neuroimmunol Grp, Diepenbeek, Belgium. | Keywords: | Myasthenia gravis; Mycophenolate mofetil; Immunosuppression; Acetylcholine receptor; Neuromuscular junction | Document URI: | http://hdl.handle.net/1942/9847 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/j.jneuroim.2008.05.029 | ISI #: | 000260294800018 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2009 |
Appears in Collections: | Research publications |
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