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http://hdl.handle.net/1942/9994
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DC Field | Value | Language |
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dc.contributor.author | ter Beek, W. Pascale | - |
dc.contributor.author | Martinez-Martinez, Pilar | - |
dc.contributor.author | Losen, Mario | - |
dc.contributor.author | DE BAETS, Marc | - |
dc.contributor.author | Wintzen, Axel R. | - |
dc.contributor.author | Verschuuren, Jan J. G. M. | - |
dc.contributor.author | Niks, Erik H. | - |
dc.contributor.author | van Duinen, Sjoerd G. | - |
dc.contributor.author | Vincent, Angela | - |
dc.contributor.author | Molenaar, Peter C. | - |
dc.date.accessioned | 2009-11-20T13:20:02Z | - |
dc.date.available | 2009-11-20T13:20:02Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | AMERICAN JOURNAL OF PATHOLOGY, 175(4). p. 1536-1544 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | http://hdl.handle.net/1942/9994 | - |
dc.description.abstract | Muscle-specific tyrosine kinase (MuSK) is essential for clustering of acetylcholine receptors (AChRs) at embryogenesis and likely also important for maintaining synaptic structure in adult muscle. In 5 to 7% of myasthenia gravis (MG) cases, the patients' blood contains antibodies to MuSK. To investigate the effect of MuSK-MG antibody on synapse regeneration, notexin was used to induce damage to the flexor digitorum brevis muscle. We administered aliquots of MuSK-MG patients' plasma to the flexor digitorum brevis twice daily for a period up to 21 days, and muscles were investigated ex vivo in contraction experiments. AChR levels were measured with I-125-alpha-bungarotoxin, and endplates were studied with quantitative immunohistochemistry. in normal muscles and in 14-day regenerated muscles, MuSK plasma caused impairment of nerve stimulus-induced contraction in the presence of 0.35 and 0.5 mmol/L Ca2+ with or without 100 to 400 nmol/L tubocurarine. Endplate size was decreased in regenerated muscles relative to controls; however, we did not observe such differences in muscle not treated with notexin. MuSK plasma had no effect on the amount and turnover rate of AChRs. Our results suggest that anti-MuSK antibodies influence the activity of MuSK molecules without reducing their number, thereby diminishing the size of the endplate and affecting the functioning of AChRs. (Am J Pathol 2009, 175:1536-1544; DOI: 10.2353/ajpath.2009.090040) | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC INVESTIGATIVE PATHOLOGY, INC | - |
dc.title | The Effect of Plasma From Muscle-Specific Tyrosine Kinase Myasthenia Patients on Regenerating Endplates | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1544 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1536 | - |
dc.identifier.volume | 175 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Martinez-Martinez, Pilar; Losen, Mario; de Baets, Marc H.; Molenaar, Peter C.] Univ Maastricht, Sch Mental Hlth & Neurosci, Dept Neurosci, European Grad Sch Neurosci EURON,Neuroimmunol Grp, NL-6200 MD Maastricht, Netherlands. [ter Beek, W. Pascale; Molenaar, Peter C.] Leiden Univ, Med Ctr, Neurophysiol Sect, Dept Mol Cell Biol, Leiden, Netherlands. [Wintzen, Axel R.; Verschuuren, Jan J. G. M.; Niks, Erik H.; van Duinen, Sjoerd G.] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands. [de Baets, Marc H.] Hasselt Univ, Neuroimmunol Grp, Biomed Res Inst BIOMED, Diepenbeek, Belgium. [Vincent, Angela] Univ Oxford, John Radcliffe Hosp, Neurosci Grp, Weatherall Inst Mol Med, Oxford OX3 9DU, England. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.2353/ajpath.2009.090040 | - |
dc.identifier.isi | 000270503100020 | - |
item.validation | ecoom 2010 | - |
item.fullcitation | ter Beek, W. Pascale; Martinez-Martinez, Pilar; Losen, Mario; DE BAETS, Marc; Wintzen, Axel R.; Verschuuren, Jan J. G. M.; Niks, Erik H.; van Duinen, Sjoerd G.; Vincent, Angela & Molenaar, Peter C. (2009) The Effect of Plasma From Muscle-Specific Tyrosine Kinase Myasthenia Patients on Regenerating Endplates. In: AMERICAN JOURNAL OF PATHOLOGY, 175(4). p. 1536-1544. | - |
item.contributor | ter Beek, W. Pascale | - |
item.contributor | Martinez-Martinez, Pilar | - |
item.contributor | Losen, Mario | - |
item.contributor | DE BAETS, Marc | - |
item.contributor | Wintzen, Axel R. | - |
item.contributor | Verschuuren, Jan J. G. M. | - |
item.contributor | Niks, Erik H. | - |
item.contributor | van Duinen, Sjoerd G. | - |
item.contributor | Vincent, Angela | - |
item.contributor | Molenaar, Peter C. | - |
item.accessRights | Closed Access | - |
item.fulltext | No Fulltext | - |
crisitem.journal.issn | 0002-9440 | - |
crisitem.journal.eissn | 1525-2191 | - |
Appears in Collections: | Research publications |
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