Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/38888
Title: NOVEL ANTIBODY BIOMARKERS THAT PREDICT FAILURE TO ACHIEVE EARLY AND SUSTAINED DISEASE REMISSION OR LOW DISEASE ACTIVITY AFTER INTENSIVE FIRST-LINE THERAPY IN RHEUMATOID ARTHRITIS
Authors: VANDORMAEL, Patrick 
PUES, Astrid 
SLEURS, Ellen 
LIESENBORGS, Jori 
Verschueren, P.
SOMERS, Veerle 
Issue Date: 2022
Publisher: BMJ PUBLISHING GROUP
Source: ANNALS OF THE RHEUMATIC DISEASES, 81 , p. 299
Abstract: Scientific Abstracts 299 ANOSIM). Detailly, at the genera level, IIM patients had a higher abundance of Ente-rococcus, Veillonella, Streptococcus, et al. and a lower abundance of Roseburia, Lachnospira, Klebsiella, et al(Figure 1D, p < 0.05). In IIM patients, Fusobacteriota correlated positively with the ratio of Th1 cells (Figure 1E, p < 0.01), and there was a significant positive correlation between Synergistota and B lymphocyte (Figure 1E, p < 0.01). Besides, Euryarchaeota and Cyanobacteria were both positively and significantly related to IL-6, IFN-γ and C-reactive protein (CRP) (Figure 1E, p < 0.001). Conclusion: Richness and diversity of intestinal flora in IIM patients were impaired, which might participate in the pathogenesis of IIM by disturbing lym-phocyte subpopulations and cytokines. Regulating intestinal flora and restoring homeostasis might become a critical therapeutic methods of IIM. REFERENCES: [1] Xu Y, Sun J, Wan K, et al. Multiparametric cardiovascular magnetic resonance characteristics and dynamic changes in myocardial and skeletal muscles in idiopathic inflammatory cardiomyopathy. J Cardiovasc Magn Reson 2020;22(1):22.
Document URI: http://hdl.handle.net/1942/38888
ISSN: 0003-4967
e-ISSN: 1468-2060
DOI: 10.1136/annrheumdis-2022-eular.2388
ISI #: 000850279001084
Category: M
Type: Journal Contribution
Appears in Collections:Research publications

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