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http://hdl.handle.net/1942/10164
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DC Field | Value | Language |
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dc.contributor.advisor | RIGO, J. | - |
dc.contributor.author | NOTELAERS, Kristof | - |
dc.date.accessioned | 2009-12-14T09:40:47Z | - |
dc.date.available | 2009-12-14T09:40:47Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://hdl.handle.net/1942/10164 | - |
dc.description.abstract | Based on recent electrophysiological data, we hypothesized a possible role for neutral amino acid transporters in glycine modulation of microglial activity. Since it has been demonstrated that calcium (Ca2+) signals correlate to microglial activity, Ca2+ signal modulation was investigated. Results showed that glycine enhanced microglial Ca2+ signals induced by ATP, LPS and thapsigargin. These effects were GlyR-independent and could be blocked by the competitive amino acid transporter substrate AIB ('-amino-isobutyric acid). Glycine immunostaining also showed an AIB-sensitive uptake of glycine in microglial cells. Together, these results provide strong arguments for neutral amino acid transporter involvement in glycine enhancement of microglial Ca2+ signals. Additional results obtained using ELISA assays, showed enhanced TNF-' production in glycine conditions. This further confirms that the immune function of microglial cells is enhanced by glycine and that the glycine effects on microg | - |
dc.format.mimetype | Application/pdf | - |
dc.language | nl | - |
dc.publisher | tUL Diepenbeek | - |
dc.title | Glycine enhances microglial calcium fluxes: A possible role for neutral amino acid transporters | - |
dc.type | Theses and Dissertations | - |
local.format.pages | 40 | - |
local.bibliographicCitation.jcat | T2 | - |
dc.description.notes | 2de masterjaar in de biomedische wetenschappen - klinische moleculaire wetenschappen | - |
local.type.specified | Master thesis | - |
dc.bibliographicCitation.oldjcat | - | |
item.accessRights | Open Access | - |
item.contributor | NOTELAERS, Kristof | - |
item.fullcitation | NOTELAERS, Kristof (2009) Glycine enhances microglial calcium fluxes: A possible role for neutral amino acid transporters. | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Master theses |
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File | Description | Size | Format | |
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04217172008249c.pdf | 1.11 MB | Adobe PDF | View/Open |
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