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Title: Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit
Authors: Casteels, Kristina
FIEUWS, Steffen 
van Helvoirt, Maria
Verpoorten, Carla
Goemans, Nathalie
Coudyzer, Walter
Loeckx, Dirk
de Zegher, Francis
Issue Date: 2010
Source: PEDIATRIC DIABETES, 11 (1). p. 61-69
Abstract: The aim of this randomized, placebo-controlled study was to explore the effect of metformin in children with a neurogenic or myogenic motor deficit, who are therefore prone to develop overweight, adiposity, and insulin resistance. Study participants (n = 42) had a mean age of 15.5 yr, a short stature (height -2.4 SD), a relatively high BMI (+1.7 SD), and a high body fat fraction (41.9% or +2.8 SD). Abdominal CT confirmed the high fat mass and disclosed a high fraction of visceral fat. As expected, insulin resistance was increased. As compared to placebo, metformin intake for 6 months exerted an insulin sensitizing effect and lowered weight (mean difference of 2 kg within 6 months, p = 0.007) and BMI (p = 0.016). Weight loss appeared to be primarily due to loss of visceral fat (similar to 20% vs. placebo; p < 0.0001). Results were similar across diagnostic subgroups. In conclusion, metformin treatment for 6 months was associated with a rise in insulin sensitivity and with a reduction of visceral adiposity in children and adolescents with a primary muscle disorder or with a neural tube defect. These findings suggest that insulin resistance underpins, at least partly, the overweight and visceral adiposity of these patients, who are not necessarily obese.
Notes: [Casteels, Kristina; van Helvoirt, Maria; Verpoorten, Carla; Goemans, Nathalie; de Zegher, Francis] UZ Leuven, Dept Pediat, B-3000 Leuven, Belgium. [Fieuws, Steffen] Katholieke Univ Leuven, I BioStat, Leuven, Belgium. [Fieuws, Steffen] Univ Hasselt, Leuven, Belgium. [Coudyzer, Walter] UZ Leuven, Dept Radiol, Leuven, Belgium. [Loeckx, Dirk] Katholieke Univ Leuven, Fac Engn, ESAT PSI, Leuven, Belgium.
Keywords: body composition; insulin resistance; metformin; neural tube defect; neuromuscular disease;body composition; insulin resistance; metformin; neural tube defect; neuromuscular disease
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ISSN: 1399-543X
e-ISSN: 1399-5448
DOI: 10.1111/j.1399-5448.2009.00512.x
ISI #: 000274188900011
Category: A1
Type: Journal Contribution
Validations: ecoom 2011
Appears in Collections:Research publications

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