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Title: Semiconducting to metallic-like boron doping of nanocrystalline diamond films and its effect on osteoblastic cells
Authors: Kromka, Alexander
Grausova, Lubica
Bacakova, Lucie
Vacik, Jiri
Rezek, Bohuslav
Vanecek, Milan
Issue Date: 2010
Source: DIAMOND AND RELATED MATERIALS, 19(2-3). p. 190-195
Abstract: The impact of boron doping level of nanocrystalline diamond (NCD) films on the character of cell growth (i.e., adhesion, proliferation and differentiation) is presented. Intrinsic and boron-doped NCD films were grown on Si/SiO2 substrates by microwave plasma CVD process. The boron-doped samples were grown by adding trimethylboron JMB) to the gas mixture of methane and hydrogen. Highly resistive (0 ppm), semiconducting (133 or 1000 ppm), and metallic-like (6700 ppm) NCD films were tested as the artificial substrates for the cultivation of osteoblast-like MG 63 cells. The conductivity and surface charge increased monotonically with the increasing boron content. All NCD substrates showed good biocompatibility and stimulated the adhesion and growth of MG 63 cells. Higher osteocalcin concentration (by more than 30%) for the cells growing on 1000 and 6700 ppm boron-doped NCD films was found which indicates an enhancement in the cell growth biochemistry. (C) 2009 Elsevier B.V. All rights reserved.
Notes: [Kromka, Alexander; Rezek, Bohuslav; Vanecek, Milan] Acad Sci Czech Republic, Inst Phys, Vvi, CZ-16253 Prague 6, Czech Republic. [Grausova, Lubica; Bacakova, Lucie] Acad Sci Czech Republic, Inst Physiol, Vvi, CR-14220 Prague, Czech Republic. [Vacik, Jiri] Acad Sci Czech Republic, Inst Nucl Phys, Vvi, Rez Near Prague 25068, Czech Republic. [Williams, Oliver A.; Haenen, Ken] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Williams, Oliver A.; Haenen, Ken] IMEC VZW, Div IMOMEC, B-3590 Diepenbeek, Belgium.
Keywords: Nanocrystalline diamond; Boron doping; Atomic force microscopy; Tissue engineering
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ISSN: 0925-9635
e-ISSN: 1879-0062
DOI: 10.1016/j.diamond.2009.10.003
ISI #: 000275101800021
Category: A1
Type: Journal Contribution
Validations: ecoom 2011
Appears in Collections:Research publications

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