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|Title:||Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients||Authors:||HANSEN, Dominique
Jonkers, Richard A. M.
van Loon, Luc J. C.
|Issue Date:||2010||Publisher:||SPRINGER||Source:||EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 109 (3). p. 397-404||Abstract:||Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these altered plasma concentrations are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal plasma FFA, inflammatory marker, and adipokine concentrations between obese and non-obese type 2 diabetes patients and healthy, non-obese controls. A total of 20 healthy, normoglycemic males (BMI < 30 kg/m(2)), 20 non-obese (BMI < 30 kg/m(2)) and 20 obese (BMI > 35 kg/m(2)) type 2 diabetes patients were selected to participate in this study. Groups were matched for age and habitual physical activity level. Body composition, glycemic control, and exercise performance capacity were assessed. Basal blood samples were collected to determine plasma leptin, adiponectin, resistin, tumor necrosis factor alpha (TNF alpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and FFA concentrations. Plasma FFA, inflammatory marker (hsCRP, IL-6, TNF alpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls. Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05). Significant correlations between plasma parameters and glycemic control were observed, but disappeared after adjusting for trunk adipose tissue mass. Elevated plasma leptin, hsCRP, IL-6, and FFA concentrations are associated with obesity and not necessarily with the type 2 diabetic state.||Notes:||[Hansen, Dominique; Meeusen, Romain] Vrije Univ Brussel, Dept Human Physiol & Sportsmed, Brussels, Belgium. [Hansen, Dominique; Dendale, Paul] Jessa Hosp, Rehabil & Hlth Ctr, Heart Ctr Hasselt, Hasselt, Belgium. [Dendale, Paul] Hasselt Univ, Fac Med, Hasselt, Belgium. [Beelen, Milou; Jonkers, Richard A. M.; van Loon, Luc J. C.] Maastricht Univ, Med Ctr, Nutr & Toxicol Res Inst Maastricht NUTRIM, Dept Human Movement Sci, NL-6200 MD Maastricht, Netherlands. [Mullens, Annelies] Jessa Hosp, Dept Endocrinol, Hasselt, Belgium. [Corluy, Luk] Jessa Hosp, Dept Rheumatol, Hasselt, Belgium. Hansen_dominique@yahoo.com; L.vanLoon@HB.unimaas.nl||Keywords:||Obesity; Diabetes; Adipokines; Inflammation; Fat mass;Obesity; Diabetes; Adipokines; Inflammation; Fat mass||Document URI:||http://hdl.handle.net/1942/11010||ISSN:||1439-6319||e-ISSN:||1439-6327||DOI:||10.1007/s00421-010-1362-5||ISI #:||000277956200005||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2011|
|Appears in Collections:||Research publications|
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