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Title: | Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer | Authors: | BUYSE, Marc | Issue Date: | 2009 | Publisher: | SPRINGER TOKYO | Source: | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101 | Abstract: | Meta-analysis is the statistical process of combining information from several studies addressing the same question. Meta-analyses based on individual patient data are far more reliable and informative than those based on summary statistics obtained from the trialists or extracted from the published literature. Meta-analysis of randomized clinical trials may contribute to therapeutic progress through (1) establishing efficacy benefits beyond a reasonable doubt, (2) identifying sources of heterogeneity between trials, (3) studying subsets reliably, (4) confirming differences in toxicity profiles, (5) evaluating the cost-effectiveness of experimental therapies, (6) assessing surrogate endpoints, and (7) addressing ancillary questions. All of these potential contributions are illustrated with examples in early and advanced colorectal cancer. | Notes: | [Buyse, Marc] Int Inst Drug Dev, Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. marc.buyse@iddi.com | Keywords: | Meta-analysis; Colorectal cancer;Meta-analysis; Colorectal cancer | Document URI: | http://hdl.handle.net/1942/11432 | ISSN: | 1341-9625 | e-ISSN: | 1437-7772 | DOI: | 10.1007/s10147-009-0879-2 | ISI #: | 000265498500004 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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