Please use this identifier to cite or link to this item:
Title: Exploring the Impact of Exposure to Primary Varicella in Children on Varicella-Zoster Virus Immunity of Parents
Authors: Ogunjimi, Benson
Smits, Evelien
HENS, Niel 
Hens, Annick
Lenders, Kevin
Ieven, Margareta
Van Tendeloo, Viggo
Van Damme, Pierre
Beutels, Philippe
Issue Date: 2011
Source: VIRAL IMMUNOLOGY, 24(2). p. 151-157
Abstract: Varicella-zoster virus (VZV) causes both primary varicella, and through reactivation of the virus, herpes zoster. It is hypothesized that VZV-immune adults may reduce the probability of developing herpes zoster through exposure to varicella. In this study we examine the existence of immunological boosting in VZV-immune adults after close contact with primary varicella. We followed-up 18 parents with household exposure to primary varicella for 1 y. Fifteen age-matched healthy and 20 older volunteers served as control groups. Cellular (IFN-gamma ELISPOT) and humoral responses were measured. Data analyses were performed by t-tests and linear mixed models. The young control group only showed higher cellular responses than the older control group and the exposed group 1 mo after exposure. The exposed group had a strong tendency toward higher cellular responses compared to the older control group, reaching significance 1 y post-exposure. The best fitting linear mixed model predicts a decline in cellular response of 50% between 1 wk and 1 mo post-exposure, followed by an increase to attain an 80% higher level at 1 y compared to the first week post-exposure. No significant results emerged based on the humoral response of the individual parents in the exposed group, despite a general tendency toward higher antibody concentrations in the exposed versus the control groups. No significant difference in humoral immunity was found between the control groups. One year after initial re-exposure to VZV, VZV-immune adults showed a rise in cellular response as assessed by IFN-g ELISPOT, and steady-state levels for the humoral response.
Notes: [Ogunjimi, Benson] Univ Antwerp, Fac Med, Vaccine & Infect Dis Inst, CHERMID, B-2610 Antwerp, Belgium. [Ogunjimi, Benson; Hens, Niel; Hens, Annick; Van Damme, Pierre; Beutels, Philippe] Univ Antwerp, Vaccine & Infect Dis Inst, CEV, B-2610 Antwerp, Belgium. [Smits, Evelien; Lenders, Kevin; Van Tendeloo, Viggo] Univ Antwerp, Vaccine & Infect Dis Inst, Lab Expt Hematol, B-2610 Antwerp, Belgium. [Ieven, Margareta] Univ Antwerp, Vaccine & Infect Dis Inst, Dept Microbiol, B-2610 Antwerp, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Beutels, Philippe] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia.
Document URI:
ISSN: 0882-8245
e-ISSN: 1557-8976
DOI: 10.1089/vim.2010.0031
ISI #: 000288983000010
Category: A1
Type: Journal Contribution
Validations: ecoom 2012
Appears in Collections:Research publications

Show full item record


checked on Sep 2, 2020


checked on May 21, 2022

Page view(s)

checked on May 19, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.