Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/11931
Title: | Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis | Authors: | Vrolix, Kathleen Niks, Erik H. Le Panse, Rozen van Ostaijen-ten Dam, Monique M. Muris, Anne-Hilde Jol-van der Zijde, Cornelia M. van Tol, Maarten J. D. Losen, Mario Molenaar, Peter C. van Zoelen, Everardus J. J. Berrih-Aknin, Sonia DE BAETS, Marc Verschuuren, Jan J. G. M. Martinez-Martinez, Pilar |
Issue Date: | 2011 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF NEUROIMMUNOLOGY, 232 (1-2). p. 158-165 | Abstract: | In myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients. (C) 2010 Elsevier B.V. All rights reserved. | Notes: | [Vrolix, Kathleen; Muris, Anne-Hilde; Losen, Mario; Molenaar, Peter C.; De Baets, Marc H.; Martinez-Martinez, Pilar] Maastricht Univ, Dept Neurosci, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, NL-6200 MD Maastricht, Netherlands. [Niks, Erik H.; Verschuuren, Jan J. G. M.] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands. [Le Panse, Rozen; Berrih-Aknin, Sonia] UPMC, UMR, CNRS, UMR7215,INSERM,U974,AIM,Hop Marie Lannelongue, F-92350 Le Plessis Robinson, France. [van Ostaijen-ten Dam, Monique M.; Jol-van der Zijde, Cornelia M.; van Tol, Maarten J. D.] Leiden Univ, Med Ctr, Dept Pediat, Sect Immunol Hematol Oncol Bone Marrow Transplant, NL-2300 RC Leiden, Netherlands. [van Zoelen, Everardus J. J.] Radbound Univ Nijmegen, Dept Cell Biol, NL-6525 HP Nijmegen, Netherlands. [De Baets, Marc H.] Hasselt Univ, Neuroimmunol Grp, Biomed Res Inst, Diepenbeek, Belgium. [De Baets, Marc H.] Hasselt Univ, Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. p.martinez@maastrichtuniversity.nl | Keywords: | Myasthenia gravis; Auto-antibodies; Neuromuscular junction; ErbB | Document URI: | http://hdl.handle.net/1942/11931 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/j.jneuroim.2010.10.024 | ISI #: | 000289493700021 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2012 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
baets 1.pdf Restricted Access | Published version | 484.82 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
9
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
6
checked on Oct 12, 2024
Page view(s)
108
checked on Sep 7, 2022
Download(s)
88
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.