Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11931
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dc.contributor.authorVrolix, Kathleen-
dc.contributor.authorNiks, Erik H.-
dc.contributor.authorLe Panse, Rozen-
dc.contributor.authorvan Ostaijen-ten Dam, Monique M.-
dc.contributor.authorMuris, Anne-Hilde-
dc.contributor.authorJol-van der Zijde, Cornelia M.-
dc.contributor.authorvan Tol, Maarten J. D.-
dc.contributor.authorLosen, Mario-
dc.contributor.authorMolenaar, Peter C.-
dc.contributor.authorvan Zoelen, Everardus J. J.-
dc.contributor.authorBerrih-Aknin, Sonia-
dc.contributor.authorDE BAETS, Marc-
dc.contributor.authorVerschuuren, Jan J. G. M.-
dc.contributor.authorMartinez-Martinez, Pilar-
dc.date.accessioned2011-05-12T14:12:29Z-
dc.date.availableNO_RESTRICTION-
dc.date.available2011-05-12T14:12:29Z-
dc.date.issued2011-
dc.identifier.citationJOURNAL OF NEUROIMMUNOLOGY, 232 (1-2). p. 158-165-
dc.identifier.issn0165-5728-
dc.identifier.urihttp://hdl.handle.net/1942/11931-
dc.description.abstractIn myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients. (C) 2010 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipThe authors thank Ingrid Hegeman for their technical support, Geraldine Cizeron-Clairac for her involvement in microarrays and Catelijne Stortelers for carrying out Western blot analyses for detecting the presence of anti-ErbB antibodies. We thank Philippe Dartevelle and Alain Serraf for the thymic samples, and Vincent de Montpreville for histological analyses on the french cohort of patients. This work was supported by a grant from the European Myastaid Project (LSHM-CT-2006-037833) and the Association Francaise contre les Myopathies (AFM).-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.subject.otherMyasthenia gravis; Auto-antibodies; Neuromuscular junction; ErbB-
dc.titleReduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis-
dc.typeJournal Contribution-
dc.identifier.epage165-
dc.identifier.issue1-2-
dc.identifier.spage158-
dc.identifier.volume232-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notes[Vrolix, Kathleen; Muris, Anne-Hilde; Losen, Mario; Molenaar, Peter C.; De Baets, Marc H.; Martinez-Martinez, Pilar] Maastricht Univ, Dept Neurosci, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, NL-6200 MD Maastricht, Netherlands. [Niks, Erik H.; Verschuuren, Jan J. G. M.] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands. [Le Panse, Rozen; Berrih-Aknin, Sonia] UPMC, UMR, CNRS, UMR7215,INSERM,U974,AIM,Hop Marie Lannelongue, F-92350 Le Plessis Robinson, France. [van Ostaijen-ten Dam, Monique M.; Jol-van der Zijde, Cornelia M.; van Tol, Maarten J. D.] Leiden Univ, Med Ctr, Dept Pediat, Sect Immunol Hematol Oncol Bone Marrow Transplant, NL-2300 RC Leiden, Netherlands. [van Zoelen, Everardus J. J.] Radbound Univ Nijmegen, Dept Cell Biol, NL-6525 HP Nijmegen, Netherlands. [De Baets, Marc H.] Hasselt Univ, Neuroimmunol Grp, Biomed Res Inst, Diepenbeek, Belgium. [De Baets, Marc H.] Hasselt Univ, Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. p.martinez@maastrichtuniversity.nl-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1016/j.jneuroim.2010.10.024-
dc.identifier.isi000289493700021-
item.contributorVrolix, Kathleen-
item.contributorNiks, Erik H.-
item.contributorLe Panse, Rozen-
item.contributorvan Ostaijen-ten Dam, Monique M.-
item.contributorMuris, Anne-Hilde-
item.contributorJol-van der Zijde, Cornelia M.-
item.contributorvan Tol, Maarten J. D.-
item.contributorLosen, Mario-
item.contributorMolenaar, Peter C.-
item.contributorvan Zoelen, Everardus J. J.-
item.contributorBerrih-Aknin, Sonia-
item.contributorDE BAETS, Marc-
item.contributorVerschuuren, Jan J. G. M.-
item.contributorMartinez-Martinez, Pilar-
item.validationecoom 2012-
item.fullcitationVrolix, Kathleen; Niks, Erik H.; Le Panse, Rozen; van Ostaijen-ten Dam, Monique M.; Muris, Anne-Hilde; Jol-van der Zijde, Cornelia M.; van Tol, Maarten J. D.; Losen, Mario; Molenaar, Peter C.; van Zoelen, Everardus J. J.; Berrih-Aknin, Sonia; DE BAETS, Marc; Verschuuren, Jan J. G. M. & Martinez-Martinez, Pilar (2011) Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis. In: JOURNAL OF NEUROIMMUNOLOGY, 232 (1-2). p. 158-165.-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
crisitem.journal.issn0165-5728-
crisitem.journal.eissn1872-8421-
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