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http://hdl.handle.net/1942/11931| Title: | Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis | Authors: | Vrolix, Kathleen Niks, Erik H. Le Panse, Rozen van Ostaijen-ten Dam, Monique M. Muris, Anne-Hilde Jol-van der Zijde, Cornelia M. van Tol, Maarten J. D. Losen, Mario Molenaar, Peter C. van Zoelen, Everardus J. J. Berrih-Aknin, Sonia DE BAETS, Marc Verschuuren, Jan J. G. M. Martinez-Martinez, Pilar |
Issue Date: | 2011 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF NEUROIMMUNOLOGY, 232 (1-2). p. 158-165 | Abstract: | In myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients. (C) 2010 Elsevier B.V. All rights reserved. | Notes: | [Vrolix, Kathleen; Muris, Anne-Hilde; Losen, Mario; Molenaar, Peter C.; De Baets, Marc H.; Martinez-Martinez, Pilar] Maastricht Univ, Dept Neurosci, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, NL-6200 MD Maastricht, Netherlands. [Niks, Erik H.; Verschuuren, Jan J. G. M.] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands. [Le Panse, Rozen; Berrih-Aknin, Sonia] UPMC, UMR, CNRS, UMR7215,INSERM,U974,AIM,Hop Marie Lannelongue, F-92350 Le Plessis Robinson, France. [van Ostaijen-ten Dam, Monique M.; Jol-van der Zijde, Cornelia M.; van Tol, Maarten J. D.] Leiden Univ, Med Ctr, Dept Pediat, Sect Immunol Hematol Oncol Bone Marrow Transplant, NL-2300 RC Leiden, Netherlands. [van Zoelen, Everardus J. J.] Radbound Univ Nijmegen, Dept Cell Biol, NL-6525 HP Nijmegen, Netherlands. [De Baets, Marc H.] Hasselt Univ, Neuroimmunol Grp, Biomed Res Inst, Diepenbeek, Belgium. [De Baets, Marc H.] Hasselt Univ, Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. p.martinez@maastrichtuniversity.nl | Keywords: | Myasthenia gravis; Auto-antibodies; Neuromuscular junction; ErbB | Document URI: | http://hdl.handle.net/1942/11931 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/j.jneuroim.2010.10.024 | ISI #: | 000289493700021 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2012 |
| Appears in Collections: | Research publications |
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