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Title: Critical shortage of new antibiotics in development against multidrug-resistant bacteria-Time to react is now
Authors: Freire-Moran, Laura
Aronsson, Bo
Manz, Chris
So, Anthony D.
Monnet, Dominique L.
Cars, Otto
Issue Date: 2011
Source: DRUG RESISTANCE UPDATES, 14(2). p. 118-124
Abstract: Two commercial databases (Pharmaprojects and Adis Insight R&D) were queried for antibacterial agents in clinical development. Particular attention was given to antibacterial agents for systemic administration. For each agent, reviewers were requested to indicate whether its spectrum of activity covered a set of selected multidrug-resistant bacteria, and whether it had a new mechanism of action or a new target. In addition, PubMed was searched for antibacterial agents in development that appeared in review articles. Out of 90 agents that were considered to fulfil the inclusion criteria for the analysis, 66 were new active substances. Fifteen of these could be systemically administered and were assessed as acting via a new or possibly new mechanism of action or on a new or possibly new target. Out of these, 12 agents were assessed as having documented in vitro activity against antibiotic-resistant Gram-positive bacteria and only four had documented in vitro activity against antibiotic-resistant Gram-negative bacteria. Of these four, two acted on new or possibly new targets and, crucially, none acted via new mechanisms of action. There is an urgent need to address the lack of effective treatments to meet the increasing public health burden caused by multidrug-resistant bacteria, in particular against Gram-negative bacteria. (C) 2011 Elsevier Ltd. All rights reserved.
Notes: [Cars, Otto] Uppsala Univ, Dept Med Sci, SE-75105 Uppsala, Sweden. [Freire-Moran, Laura; Aronsson, Bo] EMA, London, England. [Manz, Chris; So, Anthony D.] Duke Univ, Strateg Policy Unit Act Antibiot Resistance ReAct, Durham, NC 27706 USA. [Gyssens, Inge C.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Gyssens, Inge C.] CWZ Hosp, Nijmegen, Netherlands. [Gyssens, Inge C.] Hasselt Univ, Diepenbeek, Belgium. [Monnet, Dominique L.] European Ctr Dis Prevent & Control ECDC, Stockholm, Sweden. [Cars, Otto] Univ Uppsala Hosp, Dept Infect Dis, S-75185 Uppsala, Sweden.
Keywords: Antibiotics; Antimicrobial resistance; Antibiotic resistance; Antibacterial drug development; Novel antimicrobials; Multidrug resistant bacteria; Gap-analysis; EMA; ECDC; ReAct
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ISSN: 1368-7646
e-ISSN: 1532-2084
DOI: 10.1016/j.drup.2011.02.003
ISI #: 000291375900008
Category: A1
Type: Journal Contribution
Validations: ecoom 2012
Appears in Collections:Research publications

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