Please use this identifier to cite or link to this item:
|Title:||Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats||Authors:||Lehnert, Stefan
Van Loo, Peter
Schuit, Frans C.
|Issue Date:||2009||Source:||PloS one, 4(2), (ART N° e4456)||Abstract:||This paper connects Alu repeats, the most abundant repetitive elements in the human genome and microRNAs, small RNAs that alter gene expression at the post-transcriptional level. Base-pair complementarity could be demonstrated between the seed sequence of a subset of human microRNAs and Alu repeats that are integrated parallel (sense) in mRNAs. The most common target site coincides with the evolutionary most conserved part of Alu. A primate-specific gene cluster on chromosome 19 encodes the majority of miRNAs that target the most conserved sense Alu site. The individual miRNA genes within this cluster are flanked by an Alu-LINE signature, which has been duplicated with the clustered miRNA genes. Gene duplication events in this locus are supported by comparing repeat length variations of the LINE elements within the cluster with those in the rest of the chromosome. Thus, a dual relationship exists between an evolutionary young miRNA cluster and their Alu targets that may have evolved in the same time window. One hypothesis for this dual relationship is that these miRNAs could protect against too high rates of duplicative transposition, which would destroy the genome.||Document URI:||http://hdl.handle.net/1942/13070||Link to publication:||http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637760/||ISSN:||1932-6203||e-ISSN:||1932-6203||DOI:||10.1371/journal.pone.0004456||Category:||A1||Type:||Journal Contribution|
|Appears in Collections:||Research publications|
Show full item record
Files in This Item:
|Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats.pdf||935.35 kB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.